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Items: 5

1.

Experimental Tumor

Laboratory tumor models used to study tumor development and treatment. [from NCI]

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
2.

BIBW 2992

MedGen UID:
896430
Concept ID:
C4083270
Organic Chemical; Pharmacologic Substance
3.

BIBW 2992MA2

MedGen UID:
483220
Concept ID:
C3467903
Organic Chemical; Pharmacologic Substance
4.

Gilotrif

MedGen UID:
361192
Concept ID:
C1879772
Organic Chemical; Pharmacologic Substance
5.

Afatinib dimaleate

The dimaleate salt form of afatinib, an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity. Upon administration, afatinib selectively and irreversibly binds to and inhibits the epidermal growth factor receptors 1 (ErbB1; EGFR), 2 (ErbB2; HER2), and 4 (ErbB4; HER4), and certain EGFR mutants, including those caused by EGFR exon 19 deletion mutations or exon 21 (L858R) mutations. This may result in the inhibition of tumor growth and angiogenesis in tumor cells overexpressing these RTKs. Additionally, afatinib inhibits the EGFR T790M gatekeeper mutation which is resistant to treatment with first-generation EGFR inhibitors. EGFR, HER2 and HER4 are RTKs that belong to the EGFR superfamily; they play major roles in both tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. [from NCI]

MedGen UID:
474954
Concept ID:
C3273321
Organic Chemical; Pharmacologic Substance
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