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Items: 1 to 20 of 35

1.

Ventricular Dysfunction

Impairment of the ventricle to either fill or eject adequately. [from NCI]

MedGen UID:
69305
Concept ID:
C0242973
Pathologic Function
2.

Arginine

An essential amino acid in juvenile humans, Arginine is a complex amino acid, often found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04) [from NCI]

MedGen UID:
13907
Concept ID:
C0003765
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Arginine vasopressor

The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE. [from MeSH]

MedGen UID:
2063
Concept ID:
C0003779
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
4.

Left

Being located on the left side of the body. [from HPO]

MedGen UID:
618170
Concept ID:
C0443246
Spatial Concept
5.

Left Ventricular Dysfunction

Impairment of the left ventricle to either fill or eject adequately. [from NCI]

MedGen UID:
69237
Concept ID:
C0242698
Pathologic Function
6.

Cardiac hypertrophy

Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. [from MeSH]

MedGen UID:
237196
Concept ID:
C1383860
Pathologic Function
7.

AT 10

MedGen UID:
108470
Concept ID:
C0591126
Organic Chemical; Pharmacologic Substance
8.

Idiopathic cardiomyopathy

A disease of the heart muscle or myocardium proper whose cause is unknown. [from NCI]

MedGen UID:
18634
Concept ID:
C0033141
Disease or Syndrome
9.

Heart failure

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. [from MeSH]

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
10.

Hypertrophy

Abnormal enlargement of a body part or organ. [from NCI]

MedGen UID:
5703
Concept ID:
C0020564
Pathologic Function
11.

Heart Failure

MedGen UID:
880986
Concept ID:
CN236639
Disease or Syndrome
12.

Cavity

MedGen UID:
734294
Concept ID:
C1510420
Anatomical Abnormality
13.

Dilatation

A pathophysiological process characterized by the dilatation or expansion of a hollow, tubular tissue or organ. [from NCI]

MedGen UID:
41577
Concept ID:
C0012359
Pathologic Function
14.

Congestive heart failure

Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales. [from NCI]

MedGen UID:
9169
Concept ID:
C0018802
Disease or Syndrome
15.

Aneurysm

Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart. [from HPO]

MedGen UID:
8076
Concept ID:
C0002940
Anatomical Abnormality
16.

Insulins

Peptide hormones that cause an increase in the absorption of GLUCOSE by cells within organs such as LIVER, MUSCLE and ADIPOSE TISSUE. During normal metabolism insulins are produced by the PANCREATIC BETA CELLS in response to increased GLUCOSE. Natural and chemically-modified forms of insulin are also used in the treatment of GLUCOSE METABOLISM DISORDERS such as DIABETES MELLITUS. [from MeSH]

MedGen UID:
760846
Concept ID:
C3537244
Pharmacologic Substance
17.

Metabolic Networks and Pathways

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. [from MeSH]

MedGen UID:
328456
Concept ID:
C1721099
Molecular Function
18.

Female Urogenital Diseases and Pregnancy Complications

Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY. [from MeSH]

MedGen UID:
318565
Concept ID:
C1720765
Disease or Syndrome
19.

Cardiomyopathy

A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. [from NCI]

MedGen UID:
209232
Concept ID:
C0878544
Disease or Syndrome
20.

MAP Kinase Signaling System

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. [from MeSH]

MedGen UID:
155748
Concept ID:
C0752321
Molecular Function
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