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Items: 1 to 20 of 35

1.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from GTR]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
2.

Clonal Expansion

Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response. (NCI) [from NCI]

MedGen UID:
273182
Concept ID:
C1516670
Pathologic Function
3.

Mitochondrial inheritance

A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy). [from HPO]

MedGen UID:
165802
Concept ID:
C0887941
Genetic Function
4.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
5.

Mutagenesis

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. [from MeSH]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
6.

Much

A subjective response indicating that something is or was a large amount. [from NCI]

MedGen UID:
923949
Concept ID:
C4281574
Finding
7.

Process

MedGen UID:
923307
Concept ID:
C1951340
Pharmacologic Substance
8.

Nucleoside analog

synthetic or natural chemical compound resembling nucleosides in structure and/or function. [from CRISP]

MedGen UID:
890657
Concept ID:
C1579410
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
9.

progressive

MedGen UID:
851455
Concept ID:
CN232553
Finding
10.

Thyroid hormone plasma membrane transport defect

MedGen UID:
396060
Concept ID:
C1861101
Disease or Syndrome
11.

Somatic mutation

Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though they will be transmitted during any mitosis within the individual. Somatic mutations may contribute to a broad variety of pathologies including cancer. [from NCI]

MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
12.

Progressive

Advancing in extent or severity. [from NCI]

MedGen UID:
64400
Concept ID:
C0205329
Functional Concept
13.

Hiv

An infection caused by the human immunodeficiency virus. [from NCI]

MedGen UID:
5583
Concept ID:
C0019693
Disease or Syndrome
14.

Antimicrobial substance

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209727
Concept ID:
C1136254
Pharmacologic Substance
15.

Mitochondrial diseases

Mitochondrial diseases are a clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondrial respiratory chain. They can be caused by mutation of genes encoded by either nuclear DNA or mitochondrial DNA (mtDNA). While some mitochondrial disorders only affect a single organ (e.g., the eye in Leber hereditary optic neuropathy [LHON]), many involve multiple organ systems and often present with prominent neurologic and myopathic features. Mitochondrial disorders may present at any age. Many individuals with a mutation of mtDNA display a cluster of clinical features that fall into a discrete clinical syndrome, such as the Kearns-Sayre syndrome (KSS), chronic progressive external ophthalmoplegia (CPEO), mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), myoclonic epilepsy with ragged-red fibers (MERRF), neurogenic weakness with ataxia and retinitis pigmentosa (NARP), or Leigh syndrome (LS). However, considerable clinical variability exists and many individuals do not fit neatly into one particular category, which is well-illustrated by the overlapping spectrum of disease phenotypes (including mitochondrial recessive ataxia syndrome (MIRAS) resulting from mutation of the nuclear gene POLG, which has emerged as a major cause of mitochondrial disease. Common clinical features of mitochondrial disease – whether involving a mitochondrial or nuclear gene – include ptosis, external ophthalmoplegia, proximal myopathy and exercise intolerance, cardiomyopathy, sensorineural deafness, optic atrophy, pigmentary retinopathy, and diabetes mellitus. Common central nervous system findings are fluctuating encephalopathy, seizures, dementia, migraine, stroke-like episodes, ataxia, and spasticity. A high incidence of mid- and late pregnancy loss is a common occurrence that often goes unrecognized. [from GTR]

MedGen UID:
155901
Concept ID:
C0751651
Disease or Syndrome
16.

Senility

MedGen UID:
115903
Concept ID:
C0231337
Finding
17.

Antiretroviral agent

Agents used to treat RETROVIRIDAE INFECTIONS. [from MeSH]

MedGen UID:
109361
Concept ID:
C0599685
Pharmacologic Substance
18.

Viral disease

A general term for diseases caused by viruses. [from MeSH]

MedGen UID:
53027
Concept ID:
C0042769
Disease or Syndrome
19.

Sexually Transmitted Diseases, Viral

Viral diseases which are transmitted or propagated by sexual conduct. [from MeSH]

MedGen UID:
48646
Concept ID:
C0036918
Disease or Syndrome
20.

Disease due to Retroviridae

Virus diseases caused by the RETROVIRIDAE. [from MeSH]

MedGen UID:
48440
Concept ID:
C0035369
Disease or Syndrome
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