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Items: 15

1.

Dysthymia

A chronic mood disorder in which the symptoms are similar to, though milder than, those diagnosed in depression. [from NCI]

MedGen UID:
8517
Concept ID:
C0013415
Mental or Behavioral Dysfunction
2.

Desvenlafaxine

A synthetic phenethylamine bicyclic derivative with antidepressant activity. Desvenlafaxine is a selective reuptake inhibitor of serotonin and norepinephrine due to its high binding affinities to the pre-synaptic serotonin and norepinephrine transporters. By blocking both transporters, this agent prolongs neurotransmitter activities of both serotonin and norepinephrine, thereby alleviating depressive state. [from NCI]

MedGen UID:
363670
Concept ID:
C1880288
Organic Chemical; Pharmacologic Substance
3.

Milnacipran

MedGen UID:
323468
Concept ID:
C1533126
Organic Chemical; Pharmacologic Substance
4.

Agomelatine

MedGen UID:
199588
Concept ID:
C0971637
Organic Chemical; Pharmacologic Substance
5.

Reboxetine

MedGen UID:
63532
Concept ID:
C0168388
Organic Chemical; Pharmacologic Substance
6.

Brofaromine

MedGen UID:
62975
Concept ID:
C0054085
Organic Chemical; Pharmacologic Substance
7.

Amineptine

MedGen UID:
62469
Concept ID:
C0051607
Organic Chemical; Pharmacologic Substance
8.

Protriptyline

MedGen UID:
46171
Concept ID:
C0033743
Organic Chemical; Pharmacologic Substance
9.

Isocarboxazid

A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05) [from NCI]

MedGen UID:
43967
Concept ID:
C0022154
Organic Chemical; Pharmacologic Substance
10.

Tianeptine

MedGen UID:
37685
Concept ID:
C0076652
Organic Chemical; Pharmacologic Substance
11.

Nefazodone

A drug used to treat depression. It belongs to the family of drugs called antidepressant agents. [from NCI_NCI-GLOSS]

MedGen UID:
32214
Concept ID:
C0068485
Organic Chemical; Pharmacologic Substance
12.

trimipramine

MedGen UID:
21693
Concept ID:
C0041056
Organic Chemical; Pharmacologic Substance
13.

Dothiepin

A tricyclic antidepressant with some tranquilizing action. [from MeSH]

MedGen UID:
8476
Concept ID:
C0013065
Organic Chemical; Pharmacologic Substance
14.

Lofepramine

A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE. [from MeSH]

MedGen UID:
6131
Concept ID:
C0023961
Organic Chemical; Pharmacologic Substance
15.

Amoxapine

A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent. [from NCI]

MedGen UID:
1887
Concept ID:
C0002644
Organic Chemical; Pharmacologic Substance
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