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Items: 3

1.

Interleukin-12

A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42153&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42153&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1380" NCI Thesaurus) [from PDQ]

MedGen UID:
50116
Concept ID:
C0123759
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
2.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
3.

Ro-23-6019

MedGen UID:
214655
Concept ID:
C0919268
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
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