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1.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus). [from HPO]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
2.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
3.

Epithelial-myoepithelial carcinoma

Extraskeletal myxoid chondrosarcoma is a rare soft tissue neoplasm of chondroblastic origin. The tumors are most commonly found in middle-aged and elderly individuals, are more common among men, and are often detected as deep-seated lesions in the extremities. Despite their relatively low-grade malignancy, recurrence and metastasis may appear many years after the initial diagnosis. Histologic tissue section examination reveals a mixture of cellular and myxoid stromal components (Panagopoulos et al., 2002). [from OMIM]

MedGen UID:
220892
Concept ID:
C1275278
Neoplastic Process
4.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
5.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
6.

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis

SOFT syndrome is characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed (summary by Sarig et al., 2012). [from OMIM]

MedGen UID:
762199
Concept ID:
C3542022
Disease or Syndrome
7.

Hyaline degeneration

A process of tissue replacement where the tissue is being replaced by hyaline or the tissue has degenerated to hyaline. [from NCI]

MedGen UID:
473044
Concept ID:
C0333438
Pathologic Function
8.

Primary cortisol resistance

MedGen UID:
443921
Concept ID:
C2930863
Disease or Syndrome
9.

Mucinous Differentiation

MedGen UID:
269342
Concept ID:
C1513717
Finding
10.

Neoplasm

A malignant tumor at the original site of growth. [from NCI]

MedGen UID:
227011
Concept ID:
C1306459
Neoplastic Process
11.

Epithelial-Myoepithelial Carcinoma

A malignant neoplasm which occurs mostly in the major salivary glands (most frequently in the parotid gland), but also in the minor salivary glands of the oral mucosa and the tracheobronchial tree. It is characterized by the presence of ductal structures which are lined by an inner layer of cuboidal epithelial-type cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm. [from NCI]

MedGen UID:
90776
Concept ID:
C0334392
Neoplastic Process
12.

Mucoepidermoid Carcinoma

A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240) [from MeSH]

MedGen UID:
61662
Concept ID:
C0206694
Neoplastic Process
13.

Focal

Area of greatest concentration, attention, or activity; a central point or locus, especially of an infection. [from NCI]

MedGen UID:
61391
Concept ID:
C0205234
Spatial Concept
14.

Negative

An absence finding of the specified component / analyte, organism or clinical sign based on the established threshold of the performed test or procedure. [Note: Negative does not necessarily imply the complete absence of the specified item.].  [from HL7]

MedGen UID:
61377
Concept ID:
C0205160
Finding
15.

Carcinomatosis

Carcinoma that has spread diffusely to an anatomic site or throughout the body. [from NCI]

MedGen UID:
104704
Concept ID:
C0205699
Neoplastic Process
16.

Undifferentiated Carcinoma

A malignant epithelial neoplasm exhibiting poor differentiation (anaplasia). [from NCI_CDISC]

MedGen UID:
60010
Concept ID:
C0205698
Neoplastic Process
17.

Sarcomatoid Carcinoma

A malignant epithelial neoplasm characterized by the presence of spindle cells. [from NCI_CDISC]

MedGen UID:
60009
Concept ID:
C0205697
Neoplastic Process
18.

Carcinoma, anaplastic

MedGen UID:
60008
Concept ID:
C0205696
Neoplastic Process
19.

Disorder of salivary gland

Your salivary glands are in your mouth. You have three pairs of major salivary glands and hundreds of small (minor) glands. They make saliva (spit) and empty it into your mouth through openings called ducts. Saliva makes your food moist, which helps you chew and swallow. It helps you digest your food. It also cleans your mouth and contains antibodies that can kill germs. . Problems with salivary glands can cause them to become irritated and swollen. You may have symptoms such as. -A bad taste in your mouth. -Difficulty opening your mouth . -Dry mouth. -Pain in your face or mouth. -Swelling of your face or neck. Causes of salivary gland problems include infections, obstruction, or cancer. Problems can also be due to other disorders, such as mumps or Sjogren's syndrome. .  [from MedlinePlus]

MedGen UID:
48537
Concept ID:
C0036093
Disease or Syndrome
20.

Stomatognathic Diseases

General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx. [from MeSH]

MedGen UID:
20960
Concept ID:
C0038368
Disease or Syndrome
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