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Items: 1 to 20 of 35

1.

Methylene-dioxymethamphetamine

A ring-substituted amphetamine derivative, structurally related to the hallucinogen mescaline, with entactogenic, neurotoxic, and motor-stimulatory activities. 3,4-methylenedioxymethamphetamine (MDMA) produces an acute, rapid enhancement in both the release of serotonin from and the inhibition of serotonin reuptake by serotonergic nerve endings in the brain. Once within the cell, MDMA depletes stores of tryptophan hydroxylase (TPH) via acute oxidative inactivation; in turn, depleted stores of TPH leave cell terminals open to damage from oxidative stress, possibly a source of MDMA neurotoxicity. This agent also induces norepinephrine, dopamine, and acetylcholine release and can act directly on a number of receptors, including alpha 2-adrenergic and 5-hydroxytryptamine (5-HT) 2A receptors. MDMA may suppress the dyskinesia associated with long-term use of L-dopamine (L-DOPA) without affecting the efficacy of L-DOPA treatment. [from NCI]

MedGen UID:
92293
Concept ID:
C0115471
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
2.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
3.

Dextrorphan

Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN. [from MeSH]

MedGen UID:
8347
Concept ID:
C0011821
Organic Chemical; Pharmacologic Substance
4.

Dextromethorphan

A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex. [from NCI]

MedGen UID:
3784
Concept ID:
C0011816
Organic Chemical; Pharmacologic Substance
5.

Amphetamine

Chemical racemic free base or equal parts of enantiomers levoamphetamine and dextroamphetamine in their pure amine or salt forms. [from SNOMEDCT_US]

MedGen UID:
266
Concept ID:
C0002658
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

Psychiatric

MedGen UID:
851585
Concept ID:
C1548428
Finding
7.

Substituted amphetamine

Class of chemicals that are analogs or derivatives of 1-phenylpropan-2-amine, including synthetic and naturally occurring amphetamines. [from SNOMEDCT_US]

MedGen UID:
825507
Concept ID:
C3839662
Organic Chemical; Pharmacologic Substance
8.

Indicated

MedGen UID:
731837
Concept ID:
C1444656
Finding
9.

Antidepressant

A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression. [from NCI]

MedGen UID:
1588
Concept ID:
C0003289
Pharmacologic Substance
10.

Metabolic Side Effects of Drugs and Substances

Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS. [from MeSH]

MedGen UID:
827251
Concept ID:
C3850157
Pathologic Function
11.

Cytochrome P-450 Enzyme Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES. [from MeSH]

MedGen UID:
827164
Concept ID:
C3850070
Pharmacologic Substance
12.

Cytochrome P-450 CYP2D6 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2D6. [from MeSH]

MedGen UID:
827152
Concept ID:
C3850058
Pharmacologic Substance
13.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
14.

l-Methorphan

MedGen UID:
66860
Concept ID:
C0242248
Organic Chemical; Pharmacologic Substance
15.

Opium alkaloid

Alkaloids found in OPIUM from PAPAVER and their derivatives that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS. [from MeSH]

MedGen UID:
66385
Concept ID:
C0221793
Organic Chemical; Pharmacologic Substance
16.

Psychotherapeutic agent

A classification of medication that acts on the central nervous system, affecting brain function, level of consciousness, mood, emotions, and behavior. [from NCI]

MedGen UID:
46201
Concept ID:
C0033978
Pharmacologic Substance
17.

Levomethorphan

MedGen UID:
44140
Concept ID:
C0023575
Organic Chemical; Pharmacologic Substance
18.

Phenethylamine

MedGen UID:
20111
Concept ID:
C0070559
Organic Chemical; Pharmacologic Substance
19.

Racemethorphan

MedGen UID:
11093
Concept ID:
C0034505
Organic Chemical; Pharmacologic Substance
20.

Phenethylamines

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed) [from MeSH]

MedGen UID:
10698
Concept ID:
C0031399
Organic Chemical; Pharmacologic Substance
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