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Mania

MedGen UID:
137909
Concept ID:
C0338831
Mental or Behavioral Dysfunction
Synonyms: Manic
SNOMED CT: Mania (231494001); Manic (231494001)
 

Definition

A state of abnormally elevated or irritable mood, arousal, and or energy levels. [from HPO]

Term Hierarchy

Conditions with this feature

Major affective disorder 1
MedGen UID:
377615
Concept ID:
C1852197
Mental or Behavioral Dysfunction
Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life.People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes. Manic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Depressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greater risk of dying by suicide than the general population.Manic and depressive episodes can include psychotic symptoms, such as false perceptions (hallucinations) or strongly held false beliefs (delusions). Mixed episodes, which have features of manic and depressive episodes at the same time, also occur in some affected individuals.Bipolar disorder often occurs with other mental health conditions, including anxiety disorders (such as panic attacks), behavioral disorders (such as attention-deficit hyperactivity disorder), and substance abuse.

Recent clinical studies

Etiology

Herold D, Usnich T, Spengler S, Sajonz B, Bauer M, Bermpohl F
J Affect Disord 2017 Sep;219:157-163. Epub 2017 Apr 27 doi: 10.1016/j.jad.2017.04.065. PMID: 28551555
Serra G, Uchida M, Battaglia C, Casini MP, De Chiara L, Biederman J, Vicari S, Wozniak J
Curr Neuropharmacol 2017 Apr;15(3):386-393. doi: 10.2174/1570159X14666160607100403. PMID: 28503110Free PMC Article
Galynker II, Yaseen ZS, Koppolu SS, Vaughan B, Szklarska-Imiolek M, Cohen LJ, Salvanti TM, Kim HJ
BMC Psychiatry 2016 Apr 12;16:98. doi: 10.1186/s12888-016-0808-7. PMID: 27071831Free PMC Article
Daglas R, Allott K, Yücel M, Pantelis C, Macneil CA, Berk M, Cotton SM
Aust N Z J Psychiatry 2016 Dec;50(12):1186-1197. Epub 2015 Dec 23 doi: 10.1177/0004867415622272. PMID: 26698823
Patel R, Reiss P, Shetty H, Broadbent M, Stewart R, McGuire P, Taylor M
BMJ Open 2015 Dec 14;5(12):e008341. doi: 10.1136/bmjopen-2015-008341. PMID: 26667012Free PMC Article

Diagnosis

Kendler KS
Psychol Med 2017 Apr;47(6):1013-1029. Epub 2016 Dec 19 doi: 10.1017/S0033291716003238. PMID: 27989245
Lin CC, Lee CT, Lo YT, Huang TL
Biomed J 2016 Aug;39(4):272-276. Epub 2016 Sep 20 doi: 10.1016/j.bj.2016.08.001. PMID: 27793269
Yolken R, Adamos M, Katsafanas E, Khushalani S, Origoni A, Savage C, Schweinfurth L, Stallings C, Sweeney K, Dickerson F
Bipolar Disord 2016 Aug;18(5):404-9. Epub 2016 Jul 17 doi: 10.1111/bdi.12416. PMID: 27425597Free PMC Article
Shansis FM, Reche M, Capp E
J Affect Disord 2016 Jun;197:1-7. Epub 2016 Mar 3 doi: 10.1016/j.jad.2016.02.064. PMID: 26950019
Daglas R, Allott K, Yücel M, Pantelis C, Macneil CA, Berk M, Cotton SM
Aust N Z J Psychiatry 2016 Dec;50(12):1186-1197. Epub 2015 Dec 23 doi: 10.1177/0004867415622272. PMID: 26698823

Therapy

McElroy SL, Keck PE
CNS Spectr 2017 Apr;22(2):170-176. Epub 2016 Nov 21 doi: 10.1017/S1092852916000717. PMID: 27866502
Yolken R, Adamos M, Katsafanas E, Khushalani S, Origoni A, Savage C, Schweinfurth L, Stallings C, Sweeney K, Dickerson F
Bipolar Disord 2016 Aug;18(5):404-9. Epub 2016 Jul 17 doi: 10.1111/bdi.12416. PMID: 27425597Free PMC Article
Shansis FM, Reche M, Capp E
J Affect Disord 2016 Jun;197:1-7. Epub 2016 Mar 3 doi: 10.1016/j.jad.2016.02.064. PMID: 26950019
Patel R, Reiss P, Shetty H, Broadbent M, Stewart R, McGuire P, Taylor M
BMJ Open 2015 Dec 14;5(12):e008341. doi: 10.1136/bmjopen-2015-008341. PMID: 26667012Free PMC Article
Glue P, Herbison P
Aust N Z J Psychiatry 2015 Dec;49(12):1215-20. Epub 2015 Nov 6 doi: 10.1177/0004867415614109. PMID: 26546499

Prognosis

Serra G, Uchida M, Battaglia C, Casini MP, De Chiara L, Biederman J, Vicari S, Wozniak J
Curr Neuropharmacol 2017 Apr;15(3):386-393. doi: 10.2174/1570159X14666160607100403. PMID: 28503110Free PMC Article
Haghighi M, Barikani R, Jahangard L, Ahmadpanah M, Bajoghli H, Sadeghi Bahmani D, Holsboer-Trachsler E, Brand S
Compr Psychiatry 2016 Aug;69:71-7. Epub 2016 May 13 doi: 10.1016/j.comppsych.2016.05.009. PMID: 27423347
Galynker II, Yaseen ZS, Koppolu SS, Vaughan B, Szklarska-Imiolek M, Cohen LJ, Salvanti TM, Kim HJ
BMC Psychiatry 2016 Apr 12;16:98. doi: 10.1186/s12888-016-0808-7. PMID: 27071831Free PMC Article
Daglas R, Allott K, Yücel M, Pantelis C, Macneil CA, Berk M, Cotton SM
Aust N Z J Psychiatry 2016 Dec;50(12):1186-1197. Epub 2015 Dec 23 doi: 10.1177/0004867415622272. PMID: 26698823
Patel R, Reiss P, Shetty H, Broadbent M, Stewart R, McGuire P, Taylor M
BMJ Open 2015 Dec 14;5(12):e008341. doi: 10.1136/bmjopen-2015-008341. PMID: 26667012Free PMC Article

Clinical prediction guides

Herold D, Usnich T, Spengler S, Sajonz B, Bauer M, Bermpohl F
J Affect Disord 2017 Sep;219:157-163. Epub 2017 Apr 27 doi: 10.1016/j.jad.2017.04.065. PMID: 28551555
Lin CC, Lee CT, Lo YT, Huang TL
Biomed J 2016 Aug;39(4):272-276. Epub 2016 Sep 20 doi: 10.1016/j.bj.2016.08.001. PMID: 27793269
Haghighi M, Barikani R, Jahangard L, Ahmadpanah M, Bajoghli H, Sadeghi Bahmani D, Holsboer-Trachsler E, Brand S
Compr Psychiatry 2016 Aug;69:71-7. Epub 2016 May 13 doi: 10.1016/j.comppsych.2016.05.009. PMID: 27423347
Galynker II, Yaseen ZS, Koppolu SS, Vaughan B, Szklarska-Imiolek M, Cohen LJ, Salvanti TM, Kim HJ
BMC Psychiatry 2016 Apr 12;16:98. doi: 10.1186/s12888-016-0808-7. PMID: 27071831Free PMC Article
Daglas R, Allott K, Yücel M, Pantelis C, Macneil CA, Berk M, Cotton SM
Aust N Z J Psychiatry 2016 Dec;50(12):1186-1197. Epub 2015 Dec 23 doi: 10.1177/0004867415622272. PMID: 26698823

Recent systematic reviews

Lambrichts S, Van Oudenhove L, Sienaert P
J Affect Disord 2017 Sep;219:149-156. Epub 2017 May 20 doi: 10.1016/j.jad.2017.05.029. PMID: 28550767
Kendler KS
Psychol Med 2017 Apr;47(6):1013-1029. Epub 2016 Dec 19 doi: 10.1017/S0033291716003238. PMID: 27989245
Bartoli F, Crocamo C, Clerici M, Carrà G
Br J Psychiatry 2017 Jan;210(1):10-15. Epub 2016 Nov 17 doi: 10.1192/bjp.bp.115.180281. PMID: 27856422
Glue P, Herbison P
Aust N Z J Psychiatry 2015 Dec;49(12):1215-20. Epub 2015 Nov 6 doi: 10.1177/0004867415614109. PMID: 26546499
Dols A, Kupka RW, van Lammeren A, Beekman AT, Sajatovic M, Stek ML
Bipolar Disord 2014 Mar;16(2):113-8. Epub 2013 Aug 6 doi: 10.1111/bdi.12104. PMID: 23919307

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