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triclocarban

MedGen UID:
36802
Concept ID:
C0077072
Organic Chemical; Pharmacologic Substance
Synonyms: 3,4,4'-trichlorocarbanilide; N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea; trichlorcarban; trichlorocarbanilide
SNOMED CT: Triclocarban (23701001); TCC - Trichlorocarbanilide (23701001); TCC - Trichlorcarbanilide (23701001); Trichlorcarbanilide (23701001); Trichlorocarbanilide (411346009); Trichlorocarbanilide (23701001)
 

Definition

A triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVtriclocarban

Recent clinical studies

Etiology

Wei L, Qiao P, Shi Y, Ruan Y, Yin J, Wu Q, Shao B
Clin Chim Acta 2017 Mar;466:133-137. Epub 2016 Dec 23 doi: 10.1016/j.cca.2016.12.024. PMID: 28025031
Ye X, Wong LY, Dwivedi P, Zhou X, Jia T, Calafat AM
Environ Sci Technol 2016 Dec 20;50(24):13548-13554. Epub 2016 Dec 6 doi: 10.1021/acs.est.6b04668. PMID: 27993070
Fu Q, Wu X, Ye Q, Ernst F, Gan J
Water Res 2016 Oct 1;102:117-24. Epub 2016 Jun 14 doi: 10.1016/j.watres.2016.06.026. PMID: 27337347
Yin J, Wei L, Shi Y, Zhang J, Wu Q, Shao B
Environ Geochem Health 2016 Oct;38(5):1125-35. Epub 2015 Oct 23 doi: 10.1007/s10653-015-9777-x. PMID: 26497189
Huang H, Du G, Zhang W, Hu J, Wu D, Song L, Xia Y, Wang X
J Appl Toxicol 2014 Sep;34(9):1060-7. Epub 2014 Apr 16 doi: 10.1002/jat.3012. PMID: 24740835

Diagnosis

Wei L, Qiao P, Shi Y, Ruan Y, Yin J, Wu Q, Shao B
Clin Chim Acta 2017 Mar;466:133-137. Epub 2016 Dec 23 doi: 10.1016/j.cca.2016.12.024. PMID: 28025031
Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH
Drug Metab Dispos 2014 Jul;42(7):1098-102. Epub 2014 Apr 14 doi: 10.1124/dmd.114.058206. PMID: 24733789Free PMC Article
Asimakopoulos AG, Wang L, Thomaidis NS, Kannan K
J Chromatogr A 2014 Jan 10;1324:141-8. Epub 2013 Nov 21 doi: 10.1016/j.chroma.2013.11.031. PMID: 24315674
Tarnow P, Tralau T, Hunecke D, Luch A
Toxicol In Vitro 2013 Aug;27(5):1467-75. Epub 2013 Mar 21 doi: 10.1016/j.tiv.2013.03.003. PMID: 23524099
Schebb NH, Buchholz BA, Hammock BD, Rice RH
J Biochem Mol Toxicol 2012 Jun;26(6):230-4. doi: 10.1002/jbt.21411. PMID: 22711420Free PMC Article

Therapy

Wei L, Qiao P, Shi Y, Ruan Y, Yin J, Wu Q, Shao B
Clin Chim Acta 2017 Mar;466:133-137. Epub 2016 Dec 23 doi: 10.1016/j.cca.2016.12.024. PMID: 28025031
Sood S, Choudhary S, Wang HC
Biochem Biophys Res Commun 2013 Sep 6;438(4):600-6. Epub 2013 Aug 11 doi: 10.1016/j.bbrc.2013.08.009. PMID: 23942114Free PMC Article
Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD
Toxicol Appl Pharmacol 2011 Sep 1;255(2):200-6. Epub 2011 Jun 25 doi: 10.1016/j.taap.2011.06.017. PMID: 21741984Free PMC Article
Ye X, Zhou X, Furr J, Ahn KC, Hammock BD, Gray EL, Calafat AM
Toxicology 2011 Aug 15;286(1-3):69-74. Epub 2011 May 23 doi: 10.1016/j.tox.2011.05.008. PMID: 21635932Free PMC Article
Halden RU, Paull DH
Environ Sci Technol 2005 Mar 15;39(6):1420-6. PMID: 15819193

Prognosis

Ley C, Sanchez Mde L, Mathur A, Yang S, Sundaram V, Parsonnet J
BMJ Open 2016 Apr 13;6(4):e010810. doi: 10.1136/bmjopen-2015-010810. PMID: 27075843Free PMC Article
Pycke BF, Roll IB, Brownawell BJ, Kinney CA, Furlong ET, Kolpin DW, Halden RU
Environ Sci Technol 2014 Jul 15;48(14):7881-90. Epub 2014 Jun 25 doi: 10.1021/es5006362. PMID: 24932693Free PMC Article
Chung E, Genco MC, Megrelis L, Ruderman JV
Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17732-7. Epub 2011 Oct 17 doi: 10.1073/pnas.1115187108. PMID: 22006313Free PMC Article
Baumann A, Lohmann W, Rose T, Ahn KC, Hammock BD, Karst U, Schebb NH
Drug Metab Dispos 2010 Dec;38(12):2130-8. Epub 2010 Sep 22 doi: 10.1124/dmd.110.034546. PMID: 20861155Free PMC Article
Halden RU, Paull DH
Environ Sci Technol 2005 Mar 15;39(6):1420-6. PMID: 15819193

Clinical prediction guides

Wei L, Qiao P, Shi Y, Ruan Y, Yin J, Wu Q, Shao B
Clin Chim Acta 2017 Mar;466:133-137. Epub 2016 Dec 23 doi: 10.1016/j.cca.2016.12.024. PMID: 28025031
Ye X, Wong LY, Dwivedi P, Zhou X, Jia T, Calafat AM
Environ Sci Technol 2016 Dec 20;50(24):13548-13554. Epub 2016 Dec 6 doi: 10.1021/acs.est.6b04668. PMID: 27993070
Yin J, Wei L, Shi Y, Zhang J, Wu Q, Shao B
Environ Geochem Health 2016 Oct;38(5):1125-35. Epub 2015 Oct 23 doi: 10.1007/s10653-015-9777-x. PMID: 26497189
Asimakopoulos AG, Thomaidis NS, Kannan K
Sci Total Environ 2014 Feb 1;470-471:1243-9. Epub 2013 Nov 16 doi: 10.1016/j.scitotenv.2013.10.089. PMID: 24246946
Yueh MF, Li T, Evans RM, Hammock B, Tukey RH
PLoS One 2012;7(6):e37705. Epub 2012 Jun 15 doi: 10.1371/journal.pone.0037705. PMID: 22761658Free PMC Article

Recent systematic reviews

Witorsch RJ, Thomas JA
Crit Rev Toxicol 2010 Nov;40 Suppl 3:1-30. doi: 10.3109/10408444.2010.515563. PMID: 20932229

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