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Chronic obstructive pulmonary disease(COPD)

MedGen UID:
9818
Concept ID:
C0024117
Disease or Syndrome
Synonyms: COPD; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, SEVERE EARLY-ONSET
SNOMED CT: Chronic obstructive lung disease (13645005); COLD (13645005); COPD (13645005); Chronic obstructive pulmonary disease finding (413846005); Reactive airway disease (991000119106); Chronic airway obstruction (13645005); Chronic irreversible airway obstruction (13645005); CAFL - Chronic airflow limitation (13645005); COAD - Chronic obstructive airways disease (13645005); Chronic airflow limitation (13645005); CAL - Chronic airflow limitation (13645005); COPD - Chronic obstructive pulmonary disease (13645005); Chronic obstructive airway disease (13645005); Chronic airway disease (13645005); COLD - Chronic obstructive lung disease (13645005); Chronic obstructive pulmonary disease (13645005)
 
Genes (locations): HMOX1 (22q12.3); MMP1 (11q22.2); SERPINA1 (14q32.13)
OMIM®: 606963
HPO: HP:0006510

Definition

Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. Airflow obstruction is typically determined by reductions in quantitative spirometric indices, including forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) (Silverman et al., 2002; Celedon et al., 2004). [from OMIM]

Clinical features

Chronic obstructive pulmonary disease
MedGen UID:
505916
Concept ID:
CN005670
Finding

Recent clinical studies

Etiology

Stoller JK, Aboussouan LS, Kanner RE, Wilson LA, Diaz P, Wise R; LOTT Research Group.
Ann Am Thorac Soc 2015 Dec;12(12):1796-804. doi: 10.1513/AnnalsATS.201506-389OC. PMID: 26653189Free PMC Article
Reddel HK
J Allergy Clin Immunol 2015 Sep;136(3):546-52. doi: 10.1016/j.jaci.2015.06.043. PMID: 26343938
Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K
Int J Chron Obstruct Pulmon Dis 2015 Feb 10;10:309-20. doi: 10.2147/COPD.S76293. PMID: 25709425Free PMC Article
Weingärtner V, Scheve C, Gerdes V, Schwarz-Eywill M, Prenzel R, Otremba B, Mühlenbrock J, Bausewein C, Higginson IJ, Voltz R, Herich L, Simon ST; PAALiativ.
Palliat Med 2015 May;29(5):420-8. Epub 2015 Jan 29 doi: 10.1177/0269216314563428. PMID: 25634633
Emme C, Mortensen EL, Rydahl-Hansen S, Østergaard B, Svarre Jakobsen A, Schou L, Phanareth K
J Clin Nurs 2014 Nov;23(21-22):3124-37. Epub 2014 Jan 30 doi: 10.1111/jocn.12553. PMID: 24476457

Diagnosis

Wurst KE, Kelly-Reif K, Bushnell GA, Pascoe S, Barnes N
Respir Med 2016 Jan;110:1-11. Epub 2015 Oct 9 doi: 10.1016/j.rmed.2015.10.004. PMID: 26525374
Pichavant M, Sharan R, Le Rouzic O, Olivier C, Hennegrave F, Rémy G, Pérez-Cruz M, Koné B, Gosset P, Just N, Gosset P
EBioMedicine 2015 Sep 26;2(11):1686-96. doi: 10.1016/j.ebiom.2015.09.040. PMID: 26870795Free PMC Article
Stoller JK, Aboussouan LS, Kanner RE, Wilson LA, Diaz P, Wise R; LOTT Research Group.
Ann Am Thorac Soc 2015 Dec;12(12):1796-804. doi: 10.1513/AnnalsATS.201506-389OC. PMID: 26653189Free PMC Article
Reddel HK
J Allergy Clin Immunol 2015 Sep;136(3):546-52. doi: 10.1016/j.jaci.2015.06.043. PMID: 26343938
Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K
Int J Chron Obstruct Pulmon Dis 2015 Feb 10;10:309-20. doi: 10.2147/COPD.S76293. PMID: 25709425Free PMC Article

Therapy

Stone IS, Barnes NC, James WY, Midwinter D, Boubertakh R, Follows R, John L, Petersen SE
Am J Respir Crit Care Med 2016 Apr 1;193(7):717-26. doi: 10.1164/rccm.201508-1647OC. PMID: 26550687
Stoller JK, Aboussouan LS, Kanner RE, Wilson LA, Diaz P, Wise R; LOTT Research Group.
Ann Am Thorac Soc 2015 Dec;12(12):1796-804. doi: 10.1513/AnnalsATS.201506-389OC. PMID: 26653189Free PMC Article
Reddel HK
J Allergy Clin Immunol 2015 Sep;136(3):546-52. doi: 10.1016/j.jaci.2015.06.043. PMID: 26343938
Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H
Int J Chron Obstruct Pulmon Dis 2015 Jul 28;10:1465-75. doi: 10.2147/COPD.S83910. PMID: 26251586Free PMC Article
Emme C, Mortensen EL, Rydahl-Hansen S, Østergaard B, Svarre Jakobsen A, Schou L, Phanareth K
J Clin Nurs 2014 Nov;23(21-22):3124-37. Epub 2014 Jan 30 doi: 10.1111/jocn.12553. PMID: 24476457

Prognosis

Stoller JK, Aboussouan LS, Kanner RE, Wilson LA, Diaz P, Wise R; LOTT Research Group.
Ann Am Thorac Soc 2015 Dec;12(12):1796-804. doi: 10.1513/AnnalsATS.201506-389OC. PMID: 26653189Free PMC Article
Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H
Int J Chron Obstruct Pulmon Dis 2015 Jul 28;10:1465-75. doi: 10.2147/COPD.S83910. PMID: 26251586Free PMC Article
Liu D, Peng SH, Zhang J, Bai SH, Liu HX, Qu JM
Int J Chron Obstruct Pulmon Dis 2015 Jul 2;10:1265-73. doi: 10.2147/COPD.S83378. PMID: 26170655Free PMC Article
Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K
Int J Chron Obstruct Pulmon Dis 2015 Feb 10;10:309-20. doi: 10.2147/COPD.S76293. PMID: 25709425Free PMC Article
Romem A, Tom SE, Beauchene M, Babington L, Scharf SM, Romem A
Palliat Med 2015 May;29(5):464-9. Epub 2015 Feb 13 doi: 10.1177/0269216315570411. PMID: 25680377

Clinical prediction guides

Pichavant M, Sharan R, Le Rouzic O, Olivier C, Hennegrave F, Rémy G, Pérez-Cruz M, Koné B, Gosset P, Just N, Gosset P
EBioMedicine 2015 Sep 26;2(11):1686-96. doi: 10.1016/j.ebiom.2015.09.040. PMID: 26870795Free PMC Article
Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H
Int J Chron Obstruct Pulmon Dis 2015 Jul 28;10:1465-75. doi: 10.2147/COPD.S83910. PMID: 26251586Free PMC Article
Candemir I, Kaymaz D, Ergun P, Demir N, Egesel N, Sengul F
Expert Rev Respir Med 2015 Aug;9(4):487-92. Epub 2015 Jul 9 doi: 10.1586/17476348.2015.1067608. PMID: 26160067
Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K
Int J Chron Obstruct Pulmon Dis 2015 Feb 10;10:309-20. doi: 10.2147/COPD.S76293. PMID: 25709425Free PMC Article
Emme C, Mortensen EL, Rydahl-Hansen S, Østergaard B, Svarre Jakobsen A, Schou L, Phanareth K
J Clin Nurs 2014 Nov;23(21-22):3124-37. Epub 2014 Jan 30 doi: 10.1111/jocn.12553. PMID: 24476457

Recent systematic reviews

Li X, Kong L, Li F, Chen C, Xu R, Wang H, Peng S, Zhou M, Li B
PLoS One 2015 Dec 23;10(12):e0145221. doi: 10.1371/journal.pone.0145221. PMID: 26700640Free PMC Article
Lee HY, Choi SM, Lee J, Park YS, Lee CH, Kim DK, Lee SM, Yoon HI, Yim JJ, Kim YW, Han SK, Yoo CG
Int J Chron Obstruct Pulmon Dis 2015 Oct 13;10:2185-92. doi: 10.2147/COPD.S91901. PMID: 26508848Free PMC Article
Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H
Int J Chron Obstruct Pulmon Dis 2015 Jul 28;10:1465-75. doi: 10.2147/COPD.S83910. PMID: 26251586Free PMC Article
Porto EF, Castro AA, Schmidt VG, Rabelo HM, Kümpel C, Nascimento OA, Jardim JR
Int J Chron Obstruct Pulmon Dis 2015 Jun 29;10:1233-9. doi: 10.2147/COPD.S63955. PMID: 26170652Free PMC Article
Kirsch F
Expert Rev Pharmacoecon Outcomes Res 2015 Apr;15(2):301-16. Epub 2015 Jan 20 doi: 10.1586/14737167.2015.1001976. PMID: 25600470

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