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Items: 7

1.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
2.

Delay

MedGen UID:
879911
Concept ID:
CN235300
Finding
3.

DNA Double Strand Break

A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in both strands of a DNA molecule. [from NCI]

MedGen UID:
267994
Concept ID:
C1511667
Cell or Molecular Dysfunction
4.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
5.

R-17934

MedGen UID:
168042
Concept ID:
C0878453
Organic Chemical; Pharmacologic Substance
6.

NSC-238159

MedGen UID:
168041
Concept ID:
C0878452
Organic Chemical; Pharmacologic Substance
7.

Nocodazole

A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different. [from NCI]

MedGen UID:
14391
Concept ID:
C0028247
Organic Chemical; Pharmacologic Substance
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