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Items: 1 to 20 of 54

1.

sunitinib

An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. [from NCI]

MedGen UID:
263033
Concept ID:
C1176020
Organic Chemical; Pharmacologic Substance
2.

Thyroid carcinoma

Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It makes hormones that help the body work normally. There are several types of cancer of the thyroid gland. You are at greater risk if you. -Are between ages 25 and 65. -Are a woman. -Are Asian. -Have a family member who has had thyroid disease. -Have had radiation treatments to your head or neck. You should see a doctor if you have a lump or swelling in your neck. Doctors use a physical exam, thyroid tests, other blood and imaging tests, and a biopsy to diagnose thyroid cancer. Treatment depends on the type of cancer you have and how far the cancer has spread. Many patients receive a combination of treatments. They may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
107811
Concept ID:
C0549473
Neoplastic Process
3.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus). [from HPO]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
4.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
5.

Thyroid carcinoma

The presence of a carcinoma of the thyroid gland. [from HPO]

MedGen UID:
505391
Concept ID:
CN002613
Finding
6.

Medullary thyroid carcinoma

The presence of a medullary carcinoma of the thyroid gland. [from HPO]

MedGen UID:
505380
Concept ID:
CN002590
Finding
7.

Medullary thyroid carcinoma

The presence of a medullary carcinoma of the thyroid gland. [from HPO]

MedGen UID:
66772
Concept ID:
C0238462
Neoplastic Process
8.

Plasminogen

Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [from NCI]

MedGen UID:
10793
Concept ID:
C0032140
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

Experimental Tumor

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. [from MeSH]

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
10.

Rare tumor

MedGen UID:
797427
Concept ID:
CN206956
Disease or Syndrome
11.

Cell Invasion

The movement of one cell type into an area normally occupied by a different cell type. [from NCI]

MedGen UID:
397081
Concept ID:
C2699153
Pathologic Function
12.

Familial medullary thyroid carcinoma

Multiple endocrine neoplasia type 2 (MEN 2) is classified into three subtypes: MEN 2A, FMTC (familial medullary thyroid carcinoma), and MEN 2B. All three subtypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN 2A and MEN 2B have an increased risk for pheochromocytoma; MEN 2A has an increased risk for parathyroid adenoma or hyperplasia. Additional features in MEN 2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a ‘marfanoid’ habitus. MTC typically occurs in early childhood in MEN 2B, early adulthood in MEN 2A, and middle age in FMTC. [from GeneReviews]

MedGen UID:
322311
Concept ID:
C1833921
Neoplastic Process
13.

Neoplasm

A malignant tumor at the original site of growth. [from NCI]

MedGen UID:
227011
Concept ID:
C1306459
Neoplastic Process
14.

Metastasis

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. [from MeSH]

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
15.

Urokinase

A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES. [from MeSH]

MedGen UID:
21790
Concept ID:
C0042071
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
16.

Growth substance

Signal molecules that are involved in the control of cell growth and differentiation. [from MeSH]

MedGen UID:
315661
Concept ID:
C1812630
Biologically Active Substance; Pharmacologic Substance
17.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
18.

Angiogenesis Modulating Agents

Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents. [from MeSH]

MedGen UID:
263447
Concept ID:
C1257849
Pharmacologic Substance
19.

Cancer, Embryonal

MedGen UID:
199639
Concept ID:
C0751364
Neoplastic Process
20.

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. [from MeSH]

MedGen UID:
154540
Concept ID:
C0596087
Biologically Active Substance; Pharmacologic Substance
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