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Items: 5

1.

Eczematous rash

A form of dermatitis characterized by red, itchy, scaly, or crusty patches that can be chronic or intermittent.(NICHD) [from NCI]

MedGen UID:
3968
Concept ID:
C0013595
Disease or Syndrome
2.

Eczema

Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. [from HPO]

MedGen UID:
504663
Concept ID:
CN000902
Finding
3.

der(1;16)(q10;p10)

MedGen UID:
272927
Concept ID:
C1515617
Cell or Molecular Dysfunction
4.

Phosphodiesterase 4 inhibitor

MedGen UID:
883528
Concept ID:
C4049968
Pharmacologic Substance
5.

Pimecrolimus

A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. However, pimecrolimus mode of action is cell-selective and does not affect Langerhans' cells/dendritic cells and primary fibroblasts. [from NCI]

MedGen UID:
204681
Concept ID:
C1099414
Organic Chemical; Pharmacologic Substance
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