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Ryanodine

MedGen UID:
48522
Concept ID:
C0035983
Organic Chemical; Pharmacologic Substance
Synonyms: Ryanodol, 3-(1H-pyrrole-2-carboxylate)
SNOMED CT: Ryania (40352008); Ryanodine (40352008)
 

Definition

A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRyanodine

Recent clinical studies

Etiology

Hendrix P, Foreman PM, Harrigan MR, Fisher WS Rd, Vyas NA, Lipsky RH, Lin M, Walters BC, Tubbs RS, Shoja MM, Pittet JF, Mathru M, Griessenauer CJ
World Neurosurg 2017 Apr;100:190-194. Epub 2017 Jan 10 doi: 10.1016/j.wneu.2016.12.132. PMID: 28087430
Zhao Y, Hu J, Zhao Z, Shen H, Bing Q, Li N
Muscle Nerve 2016 Sep;54(3):432-8. Epub 2016 May 25 doi: 10.1002/mus.25050. PMID: 26799446
Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng AJ, Ochala J, Kamandulis S, Girard S, Volungevičius G, Paužas H, Mekideche A, Kayser B, Martinez-Redondo V, Ruas JL, Bruton J, Truffert A, Lanner JT, Skurvydas A, Westerblad H
Proc Natl Acad Sci U S A 2015 Dec 15;112(50):15492-7. Epub 2015 Nov 2 doi: 10.1073/pnas.1507176112. PMID: 26575622Free PMC Article
Tian C, Shao CH, Fenster DS, Mixan M, Romberger DJ, Toews ML, Bidasee KR
J Appl Physiol (1985) 2010 Sep;109(3):830-9. Epub 2010 Jun 24 doi: 10.1152/japplphysiol.00123.2010. PMID: 20576841Free PMC Article
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H
Neuromuscul Disord 2010 Mar;20(3):166-73. Epub 2010 Jan 18 doi: 10.1016/j.nmd.2009.12.005. PMID: 20080402Free PMC Article

Diagnosis

Sun B, Guo W, Tian X, Yao J, Zhang L, Wang R, Chen SR
J Biol Chem 2016 Dec 9;291(50):26024-26034. Epub 2016 Oct 27 doi: 10.1074/jbc.M116.758821. PMID: 27789712Free PMC Article
Stefanou MI, Komorowski L, Kade S, Bornemann A, Ziemann U, Synofzik M
BMC Neurol 2016 Sep 13;16(1):172. doi: 10.1186/s12883-016-0697-x. PMID: 27623618Free PMC Article
Wescott AP, Jafri MS, Lederer WJ, Williams GS
J Mol Cell Cardiol 2016 Mar;92:82-92. Epub 2016 Jan 28 doi: 10.1016/j.yjmcc.2016.01.024. PMID: 26827896Free PMC Article
Seidel M, Thomas NL, Williams AJ, Lai FA, Zissimopoulos S
Cardiovasc Res 2015 Jan 1;105(1):118-28. Epub 2014 Nov 19 doi: 10.1093/cvr/cvu240. PMID: 25411383
Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR, Gollob MH
Channels (Austin) 2010 Jul-Aug;4(4):302-10. Epub 2010 Jul 14 PMID: 20676041Free PMC Article

Therapy

Liou B, Peng Y, Li R, Inskeep V, Zhang W, Quinn B, Dasgupta N, Blackwood R, Setchell KD, Fleming S, Grabowski GA, Marshall J, Sun Y
Hum Mol Genet 2016 Dec 1;25(23):5126-5141. doi: 10.1093/hmg/ddw322. PMID: 27655403
MacKay EJ, Wilkerson C, Kraeva N, Rosenberg H, Kennedy T
J Clin Anesth 2016 Sep;33:144-6. Epub 2016 Apr 29 doi: 10.1016/j.jclinane.2016.02.038. PMID: 27555149
Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng AJ, Ochala J, Kamandulis S, Girard S, Volungevičius G, Paužas H, Mekideche A, Kayser B, Martinez-Redondo V, Ruas JL, Bruton J, Truffert A, Lanner JT, Skurvydas A, Westerblad H
Proc Natl Acad Sci U S A 2015 Dec 15;112(50):15492-7. Epub 2015 Nov 2 doi: 10.1073/pnas.1507176112. PMID: 26575622Free PMC Article
Zhao YT, Valdivia CR, Gurrola GB, Powers PP, Willis BC, Moss RL, Jalife J, Valdivia HH
Proc Natl Acad Sci U S A 2015 Mar 31;112(13):E1669-77. Epub 2015 Mar 16 doi: 10.1073/pnas.1419795112. PMID: 25775566Free PMC Article
Tian C, Shao CH, Fenster DS, Mixan M, Romberger DJ, Toews ML, Bidasee KR
J Appl Physiol (1985) 2010 Sep;109(3):830-9. Epub 2010 Jun 24 doi: 10.1152/japplphysiol.00123.2010. PMID: 20576841Free PMC Article

Prognosis

Zheng W
Proteins 2015 Dec;83(12):2307-18. Epub 2015 Nov 17 doi: 10.1002/prot.24951. PMID: 26492335
O'Brien F, Venturi E, Sitsapesan R
Biochem Soc Trans 2015 Jun;43(3):426-33. doi: 10.1042/BST20140297. PMID: 26009186
Mei Y, Xu L, Mowrey DD, Mendez Giraldez R, Wang Y, Pasek DA, Dokholyan NV, Meissner G
J Biol Chem 2015 Jul 10;290(28):17535-45. Epub 2015 May 21 doi: 10.1074/jbc.M115.659672. PMID: 25998124Free PMC Article
Baran I, Katona E, Ganea C
Pflugers Arch 2013 Aug;465(8):1101-19. Epub 2013 Mar 9 doi: 10.1007/s00424-013-1235-y. PMID: 23475436
Cornea RL, Nitu FR, Samsó M, Thomas DD, Fruen BR
J Biol Chem 2010 Jun 18;285(25):19219-26. Epub 2010 Apr 19 doi: 10.1074/jbc.M109.066944. PMID: 20404344Free PMC Article

Clinical prediction guides

Mei Y, Xu L, Mowrey DD, Mendez Giraldez R, Wang Y, Pasek DA, Dokholyan NV, Meissner G
J Biol Chem 2015 Jul 10;290(28):17535-45. Epub 2015 May 21 doi: 10.1074/jbc.M115.659672. PMID: 25998124Free PMC Article
Girgenrath T, Mahalingam M, Svensson B, Nitu FR, Cornea RL, Fessenden JD
J Biol Chem 2013 May 31;288(22):16073-84. Epub 2013 Apr 12 doi: 10.1074/jbc.M113.463299. PMID: 23585572Free PMC Article
Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR, Gollob MH
Channels (Austin) 2010 Jul-Aug;4(4):302-10. Epub 2010 Jul 14 PMID: 20676041Free PMC Article
Cornea RL, Nitu FR, Samsó M, Thomas DD, Fruen BR
J Biol Chem 2010 Jun 18;285(25):19219-26. Epub 2010 Apr 19 doi: 10.1074/jbc.M109.066944. PMID: 20404344Free PMC Article
Hunt DJ, Jones PP, Wang R, Chen W, Bolstad J, Chen K, Shimoni Y, Chen SR
Biochem J 2007 Jun 15;404(3):431-8. doi: 10.1042/BJ20070135. PMID: 17313373Free PMC Article

Recent systematic reviews

Zhou K, Hong T
Sci China Life Sci 2017 Mar;60(3):257-263. Epub 2016 Nov 23 doi: 10.1007/s11427-016-0249-x. PMID: 27888388
Witherspoon JW, Meilleur KG
Acta Neuropathol Commun 2016 Nov 17;4(1):121. doi: 10.1186/s40478-016-0392-6. PMID: 27855725Free PMC Article
Rababa'h A, Singh S, Suryavanshi SV, Altarabsheh SE, Deo SV, McConnell BK
Int J Mol Sci 2014 Dec 24;16(1):218-29. doi: 10.3390/ijms16010218. PMID: 25547489Free PMC Article
Jabbari J, Jabbari R, Nielsen MW, Holst AG, Nielsen JB, Haunsø S, Tfelt-Hansen J, Svendsen JH, Olesen MS
Circ Cardiovasc Genet 2013 Oct;6(5):481-9. Epub 2013 Sep 11 doi: 10.1161/CIRCGENETICS.113.000118. PMID: 24025405
Yano M, Yamamoto T, Ikemoto N, Matsuzaki M
Pharmacol Ther 2005 Sep;107(3):377-91. doi: 10.1016/j.pharmthera.2005.04.003. PMID: 15951021

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