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Gadobenate dimeglumine

MedGen UID:
61916
Concept ID:
C0209453
Indicator, Reagent, or Diagnostic Aid; Organic Chemical; Pharmacologic Substance
Synonyms: gadobenate dimeglumine; gadobenic acid, dimeglumine salt; gadolinium-BOPTA-Dimeg
SNOMED CT: Gadobenate dimeglumine (414308003); Gadobenate dimeglumine (414307008); Meglumine gadobenate (414308003)
 

Definition

A gadolinium-based paramagnetic contrast agent. When placed in a magnetic field, gadobenate dimeglumine produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because gadobenate dimeglumine is excreted in the bile, it may be used to visualize the biliary system using MRI. [from NCI]

Recent clinical studies

Etiology

Furlan A, Close ON, Borhani AA, Wu YH, Heller MT
Clin Radiol 2017 Jan;72(1):93.e1-93.e6. Epub 2016 Sep 12 doi: 10.1016/j.crad.2016.08.005. PMID: 27633725
Ramalho J, Semelka RC, AlObaidy M, Ramalho M, Nunes RH, Castillo M
Eur Radiol 2016 Nov;26(11):4080-4088. Epub 2016 Feb 24 doi: 10.1007/s00330-016-4269-7. PMID: 26911888
Soulez G, Bloomgarden DC, Rofsky NM, Smith MP, Abujudeh HH, Morgan DE, Lichtenstein RJ, Schiebler ML, Wippold FJ 2nd, Russo C, Kuhn MJ, Mennitt KW, Maki JH, Stolpen A, Liou J, Semelka RC, Kirchin MA, Shen N, Pirovano G, Spinazzi A
AJR Am J Roentgenol 2015 Sep;205(3):469-78. doi: 10.2214/AJR.14.14268. PMID: 26295633
Gilbert FJ, van den Bosch HC, Petrillo A, Siegmann K, Heverhagen JT, Panizza P, Gehl HB, Pediconi F, Diekmann F, Peng WJ, Ma L, Sardanelli F, Belli P, Corcione S, Zechmann CM, Faivre-Pierret M, Martincich L
J Magn Reson Imaging 2014 May;39(5):1272-86. PMID: 25006633
Wildgruber M, Stadlbauer T, Rasper M, Hapfelmeier A, Zelger O, Eckstein HH, Halle M, Rummeny EJ, Huber AM
Invest Radiol 2014 Nov;49(11):728-34. doi: 10.1097/RLI.0000000000000076. PMID: 24872002Free PMC Article

Diagnosis

Furlan A, Close ON, Borhani AA, Wu YH, Heller MT
Clin Radiol 2017 Jan;72(1):93.e1-93.e6. Epub 2016 Sep 12 doi: 10.1016/j.crad.2016.08.005. PMID: 27633725
Weberling LD, Kieslich PJ, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Radbruch A
Invest Radiol 2015 Nov;50(11):743-8. doi: 10.1097/RLI.0000000000000206. PMID: 26352749
Amarteifio E, Essig M, Böckler D, Attigah N, Schuster L, Demirel S
J Neuroradiol 2015 Jul;42(4):236-44. Epub 2014 Jul 1 doi: 10.1016/j.neurad.2014.03.002. PMID: 24996569
Gilbert FJ, van den Bosch HC, Petrillo A, Siegmann K, Heverhagen JT, Panizza P, Gehl HB, Pediconi F, Diekmann F, Peng WJ, Ma L, Sardanelli F, Belli P, Corcione S, Zechmann CM, Faivre-Pierret M, Martincich L
J Magn Reson Imaging 2014 May;39(5):1272-86. PMID: 25006633
Wildgruber M, Stadlbauer T, Rasper M, Hapfelmeier A, Zelger O, Eckstein HH, Halle M, Rummeny EJ, Huber AM
Invest Radiol 2014 Nov;49(11):728-34. doi: 10.1097/RLI.0000000000000076. PMID: 24872002Free PMC Article

Therapy

Furlan A, Close ON, Borhani AA, Wu YH, Heller MT
Clin Radiol 2017 Jan;72(1):93.e1-93.e6. Epub 2016 Sep 12 doi: 10.1016/j.crad.2016.08.005. PMID: 27633725
Ramalho J, Semelka RC, AlObaidy M, Ramalho M, Nunes RH, Castillo M
Eur Radiol 2016 Nov;26(11):4080-4088. Epub 2016 Feb 24 doi: 10.1007/s00330-016-4269-7. PMID: 26911888
Weberling LD, Kieslich PJ, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Radbruch A
Invest Radiol 2015 Nov;50(11):743-8. doi: 10.1097/RLI.0000000000000206. PMID: 26352749
Amarteifio E, Essig M, Böckler D, Attigah N, Schuster L, Demirel S
J Neuroradiol 2015 Jul;42(4):236-44. Epub 2014 Jul 1 doi: 10.1016/j.neurad.2014.03.002. PMID: 24996569
Gilbert FJ, van den Bosch HC, Petrillo A, Siegmann K, Heverhagen JT, Panizza P, Gehl HB, Pediconi F, Diekmann F, Peng WJ, Ma L, Sardanelli F, Belli P, Corcione S, Zechmann CM, Faivre-Pierret M, Martincich L
J Magn Reson Imaging 2014 May;39(5):1272-86. PMID: 25006633

Prognosis

Weberling LD, Kieslich PJ, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Radbruch A
Invest Radiol 2015 Nov;50(11):743-8. doi: 10.1097/RLI.0000000000000206. PMID: 26352749
Yang XP, Han YD, Ye JJ, Chen G, Luo Y, Ma HX, Yu XW, Niu JQ, Ren FY, Guo YM
Asian Pac J Cancer Prev 2014;15(12):5089-95. PMID: 24998534
Davenport MS, Dillman JR, Cohan RH, Hussain HK, Khalatbari S, McHugh JB, Ellis JH
Radiology 2013 Mar;266(3):773-82. Epub 2012 Dec 13 doi: 10.1148/radiol.12120253. PMID: 23238152Free PMC Article
Li Y, Li X, Li D, Lu J, Xing X, Yan F, Li Y, Wang X, Iezzi R, De Cobelli F
AJNR Am J Neuroradiol 2013 Apr;34(4):847-54. Epub 2012 Oct 4 doi: 10.3174/ajnr.A3298. PMID: 23042922
Brismar TB, Kartalis N, Kylander C, Albiin N
Eur Radiol 2012 Mar;22(3):633-41. Epub 2011 Sep 28 doi: 10.1007/s00330-011-2288-y. PMID: 21953376Free PMC Article

Clinical prediction guides

Weberling LD, Kieslich PJ, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Radbruch A
Invest Radiol 2015 Nov;50(11):743-8. doi: 10.1097/RLI.0000000000000206. PMID: 26352749
Davenport MS, Caoili EM, Kaza RK, Hussain HK
Radiology 2014 Jul;272(1):123-31. Epub 2014 Mar 8 doi: 10.1148/radiol.14132269. PMID: 24617733
Rudolph A, von Knobelsdorff-Brenkenhoff F, Wassmuth R, Prothmann M, Utz W, Schulz-Menger J
J Magn Reson Imaging 2014 May;39(5):1153-60. Epub 2013 Oct 22 doi: 10.1002/jmri.24264. PMID: 24151119
Li Y, Li X, Li D, Lu J, Xing X, Yan F, Li Y, Wang X, Iezzi R, De Cobelli F
AJNR Am J Neuroradiol 2013 Apr;34(4):847-54. Epub 2012 Oct 4 doi: 10.3174/ajnr.A3298. PMID: 23042922
Brismar TB, Kartalis N, Kylander C, Albiin N
Eur Radiol 2012 Mar;22(3):633-41. Epub 2011 Sep 28 doi: 10.1007/s00330-011-2288-y. PMID: 21953376Free PMC Article

Recent systematic reviews

Yang XP, Han YD, Ye JJ, Chen G, Luo Y, Ma HX, Yu XW, Niu JQ, Ren FY, Guo YM
Asian Pac J Cancer Prev 2014;15(12):5089-95. PMID: 24998534

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