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Items: 6

1.

Exocrine pancreatic insufficiency

A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS. [from MeSH]

MedGen UID:
75647
Concept ID:
C0267963
Disease or Syndrome
2.

Cystic fibrosis

CFTR-related disorders include cystic fibrosis (CF) and congenital absence of the vas deferens (CAVD). Cystic fibrosis affects epithelia of the respiratory tract, exocrine pancreas, intestine, male genital tract, hepatobiliary system, and exocrine sweat glands, resulting in complex multisystem disease. Pulmonary disease is the major cause of morbidity and mortality in CF. Affected individuals have lower airway inflammation and chronic endobronchial infection, progressing to end-stage lung disease characterized by extensive airway damage (bronchiectasis, cysts, and abscesses) and fibrosis of lung parenchyma. Meconium ileus occurs at birth in 15%-20% of newborns with CF. Pancreatic insufficiency with malabsorption occurs in the great majority of individuals with CF. More than 95% of males with CF are infertile as a result of azoospermia caused by absent, atrophic, or fibrotic Wolffian duct structures. CAVD occurs in men without pulmonary or gastrointestinal manifestations of CF. Affected men have azoospermia and are thus infertile. [from GeneReviews]

MedGen UID:
41393
Concept ID:
C0010674
Disease or Syndrome
3.

Malabsorption

Impaired ability to absorb one or more nutrients from the intestine. [from HPO]

MedGen UID:
811453
Concept ID:
C3714745
Finding
4.

Exocrine pancreatic insufficiency

Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes. [from HPO]

MedGen UID:
504939
Concept ID:
CN001582
Finding
5.

Malabsorption

MedGen UID:
368423
Concept ID:
C1963165
Finding
6.

Pancreatic insufficiency

Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes. [from HPO]

MedGen UID:
45295
Concept ID:
C0030293
Disease or Syndrome
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