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Pain

MedGen UID:
45282
Concept ID:
C0030193
Sign or Symptom
Synonyms: Dolor; PAIN; Pain observations; Painful; Part hurts
SNOMED CT: Pain observations (22253000); Pain (22253000); Dolor (22253000); Painful (22253000); Part hurts (22253000)
 
HPO: HP:0012531

Definition

Pain is a feeling triggered in the nervous system. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. Pain can be helpful in diagnosing a problem. Without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. Once you take care of the problem, pain usually goes away. However, sometimes pain goes on for weeks, months or even years. This is called chronic pain. Sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. Sometimes the cause is unknown. Fortunately, there are many ways to treat pain. Treatment varies depending on the cause of pain. Pain relievers, acupuncture and sometimes surgery are helpful.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Pain

Conditions with this feature

Primary erythromelalgia
MedGen UID:
8688
Concept ID:
C0014805
Disease or Syndrome
SCN9A-related inherited erythromelalgia (SCN9A-related IEM) is characterized by recurrent attacks of bilateral and symmetric intense pain, redness, warmth, and swelling involving the feet and, less frequently, the hands. SCN9A-related IEM is not associated with an organic disease. Manifestations may vary within a family. Onset is usually in childhood or adolescence but has been recognized in infants and adults. At onset, episodes are triggered by warmth; other precipitating factors include: exercise, tight shoes, wearing socks, alcohol, spicy foods, and other vasodilating agents. In advanced disease, symptoms may occur many times a day or become constant. Some individuals have allodynia (pain evoked by a normally innocuous stimulus) and hyperalgesia (increased sensitivity to a painful stimulus). Episodes may be disabling, interfere with sleep, and severely limit normal activities such as walking, participation in sports, wearing socks and shoes, and attending school or going to work.
Charcot-Marie-Tooth disease, type 2A2
MedGen UID:
373098
Concept ID:
C1836485
Disease or Syndrome
Charcot-Marie-Tooth hereditary neuropathy type 2A (CMT2A) is a classic axonal peripheral sensorimotor neuropathy characterized by earlier and more severe involvement of the lower extremities than the upper extremities, distal upper-extremity involvement as the neuropathy progresses, more prominent motor deficits than sensory deficits, and normal (>42 m/s) or only slightly decreased nerve conduction velocities (NCVs). Postural tremor is common. Most affected individuals develop symptoms in the first or second decade. It has recently been suggested that CMT2A represents more than 90% of the severe dominant CMT2 cases. However, milder late-onset cases and unusual presentations have also been described.
Epithelial recurrent erosion dystrophy
MedGen UID:
342263
Concept ID:
C1852551
Disease or Syndrome
A rare form of superficial corneal dystrophy with recurrent episodes of epithelial erosions from childhood in the absence of associated diseases. The erosions begin spontaneously or are precipitated by minor trauma, dust or smoke. The condition may become apparent by 6 months of age, but as a rule it only starts at 4 to 6 years of age. Most patients have attacks of redness, photophobia, epiphora, and ocular pain. Some experience a burning sensation and report sensitive eyes for years. Vision is sometimes impaired. Autosomal dominant pattern of inheritance.
Cluster headache, familial
MedGen UID:
350040
Concept ID:
C1861513
Disease or Syndrome
The classification for headache disorders of the International Headache Society (1988) listed the following criteria for cluster headache (CH): at least 5 attacks of severe unilateral orbital, supraorbital, and/or temporal pain, lasting 15 to 180 minutes, associated with at least 1 of 8 local autonomic signs, and occurring once every other day to 8 per day. Approximately 85% of CH patients have the episodic subtype, in which the headaches occur in cluster periods lasting from 7 days to 1 year and separated by attack-free intervals of 1 month or more. The remainder of patients have the chronic subtype, in which attacks recur for greater than 1 year without remission or with remissions lasting less than 1 month (Lipton et al., 2004).

Recent clinical studies

Etiology

Edwards R, Eccleston C, Keogh E
Pain 2017 May;158(5):846-855. doi: 10.1097/j.pain.0000000000000840. PMID: 28141635
Vaegter HB, Graven-Nielsen T
Pain 2016 Jul;157(7):1480-8. doi: 10.1097/j.pain.0000000000000543. PMID: 26963852
Campbell CM, Carroll CP, Kiley K, Han D, Haywood C Jr, Lanzkron S, Swedberg L, Edwards RR, Page GG, Haythornthwaite JA
Pain 2016 Apr;157(4):949-56. doi: 10.1097/j.pain.0000000000000473. PMID: 26713424Free PMC Article
Meloto CB, Bortsov AV, Bair E, Helgeson E, Ostrom C, Smith SB, Dubner R, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, McLean SA, Diatchenko L
Pain 2016 Apr;157(4):858-67. doi: 10.1097/j.pain.0000000000000449. PMID: 26675825Free PMC Article
Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB
Pain 2016 Mar;157(3):560-8. doi: 10.1097/j.pain.0000000000000404. PMID: 26529271

Diagnosis

Gélinas C, Puntillo KA, Levin P, Azoulay E
Pain 2017 May;158(5):811-821. doi: 10.1097/j.pain.0000000000000834. PMID: 28362678
Vaegter HB, Graven-Nielsen T
Pain 2016 Jul;157(7):1480-8. doi: 10.1097/j.pain.0000000000000543. PMID: 26963852
Campbell CM, Carroll CP, Kiley K, Han D, Haywood C Jr, Lanzkron S, Swedberg L, Edwards RR, Page GG, Haythornthwaite JA
Pain 2016 Apr;157(4):949-56. doi: 10.1097/j.pain.0000000000000473. PMID: 26713424Free PMC Article
Meloto CB, Bortsov AV, Bair E, Helgeson E, Ostrom C, Smith SB, Dubner R, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, McLean SA, Diatchenko L
Pain 2016 Apr;157(4):858-67. doi: 10.1097/j.pain.0000000000000449. PMID: 26675825Free PMC Article
Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB
Pain 2016 Mar;157(3):560-8. doi: 10.1097/j.pain.0000000000000404. PMID: 26529271

Therapy

Racine NM, Pillai Riddell RR, Flora DB, Taddio A, Garfield H, Greenberg S
Pain 2016 Sep;157(9):1918-32. doi: 10.1097/j.pain.0000000000000590. PMID: 27276117
Honigman L, Bar-Bachar O, Yarnitsky D, Sprecher E, Granovsky Y
Pain 2016 Sep;157(9):2000-11. doi: 10.1097/j.pain.0000000000000604. PMID: 27152691Free PMC Article
Frey-Law LA, Bohr NL, Sluka KA, Herr K, Clark CR, Noiseux NO, Callaghan JJ, Zimmerman MB, Rakel BA
Pain 2016 Sep;157(9):1988-99. doi: 10.1097/j.pain.0000000000000603. PMID: 27152688Free PMC Article
Kucyi A, Salomons TV, Davis KD
Pain 2016 Sep;157(9):1895-904. doi: 10.1097/j.pain.0000000000000592. PMID: 27101426
Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB
Pain 2016 Mar;157(3):560-8. doi: 10.1097/j.pain.0000000000000404. PMID: 26529271

Prognosis

Gélinas C, Puntillo KA, Levin P, Azoulay E
Pain 2017 May;158(5):811-821. doi: 10.1097/j.pain.0000000000000834. PMID: 28362678
Edwards R, Eccleston C, Keogh E
Pain 2017 May;158(5):846-855. doi: 10.1097/j.pain.0000000000000840. PMID: 28141635
Peerdeman KJ, van Laarhoven AI, Keij SM, Vase L, Rovers MM, Peters ML, Evers AW
Pain 2016 Jun;157(6):1179-91. doi: 10.1097/j.pain.0000000000000540. PMID: 26945235
Campbell CM, Carroll CP, Kiley K, Han D, Haywood C Jr, Lanzkron S, Swedberg L, Edwards RR, Page GG, Haythornthwaite JA
Pain 2016 Apr;157(4):949-56. doi: 10.1097/j.pain.0000000000000473. PMID: 26713424Free PMC Article
Birnie KA, Chambers CT, Chorney J, Fernandez CV, McGrath PJ
Pain 2016 Apr;157(4):938-48. doi: 10.1097/j.pain.0000000000000461. PMID: 26713422

Clinical prediction guides

Gélinas C, Puntillo KA, Levin P, Azoulay E
Pain 2017 May;158(5):811-821. doi: 10.1097/j.pain.0000000000000834. PMID: 28362678
Edwards R, Eccleston C, Keogh E
Pain 2017 May;158(5):846-855. doi: 10.1097/j.pain.0000000000000840. PMID: 28141635
Honigman L, Bar-Bachar O, Yarnitsky D, Sprecher E, Granovsky Y
Pain 2016 Sep;157(9):2000-11. doi: 10.1097/j.pain.0000000000000604. PMID: 27152691Free PMC Article
Vaegter HB, Graven-Nielsen T
Pain 2016 Jul;157(7):1480-8. doi: 10.1097/j.pain.0000000000000543. PMID: 26963852
Peerdeman KJ, van Laarhoven AI, Keij SM, Vase L, Rovers MM, Peters ML, Evers AW
Pain 2016 Jun;157(6):1179-91. doi: 10.1097/j.pain.0000000000000540. PMID: 26945235

Recent systematic reviews

Peerdeman KJ, van Laarhoven AI, Keij SM, Vase L, Rovers MM, Peters ML, Evers AW
Pain 2016 Jun;157(6):1179-91. doi: 10.1097/j.pain.0000000000000540. PMID: 26945235
Jensen KB, Regenbogen C, Ohse MC, Frasnelli J, Freiherr J, Lundström JN
Pain 2016 Jun;157(6):1279-86. doi: 10.1097/j.pain.0000000000000517. PMID: 26871535
Boesch E, Bellan V, Moseley GL, Stanton TR
Pain 2016 Mar;157(3):516-29. doi: 10.1097/j.pain.0000000000000423. PMID: 26588692
Crellin DJ, Harrison D, Santamaria N, Babl FE
Pain 2015 Nov;156(11):2132-51. doi: 10.1097/j.pain.0000000000000305. PMID: 26207651
Stubbs B, Thompson T, Acaster S, Vancampfort D, Gaughran F, Correll CU
Pain 2015 Nov;156(11):2121-31. doi: 10.1097/j.pain.0000000000000304. PMID: 26207650

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