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Items: 1 to 20 of 54

1.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
2.

Swelling

Enlargement; expansion in size; sign of inflammation [from NCI]

MedGen UID:
21042
Concept ID:
C0038999
Finding
3.

Epidermal growth factor

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. [from MeSH]

MedGen UID:
66867
Concept ID:
C0242275
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
4.

Water intoxication syndrome

A condition resulting from the excessive retention of water with sodium depletion. [from MeSH]

MedGen UID:
53061
Concept ID:
C0043049
Disease or Syndrome
5.

Ethacrynic acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. [from MeSH]

MedGen UID:
41882
Concept ID:
C0014963
Organic Chemical; Pharmacologic Substance
6.

Water

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) [from MeSH]

MedGen UID:
22697
Concept ID:
C0043047
Inorganic Chemical; Pharmacologic Substance
7.

Ischemia

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. [from MeSH]

MedGen UID:
5899
Concept ID:
C0022116
Pathologic Function
8.

Furosemide

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. [from MeSH]

MedGen UID:
4807
Concept ID:
C0016860
Organic Chemical; Pharmacologic Substance
9.

Bumetanide

A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. [from NCI]

MedGen UID:
2749
Concept ID:
C0006376
Organic Chemical; Pharmacologic Substance
10.

Intoxication

Disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance. [from NCI]

MedGen UID:
196389
Concept ID:
C0728899
Finding
11.

Proliferation

MedGen UID:
137720
Concept ID:
C0334094
Pathologic Function
12.

Mitogen

A soluble substance, usually a protein, that induces mitosis in resting cells, thereby causing cell proliferation. [from NCI]

MedGen UID:
7665
Concept ID:
C0026249
Pharmacologic Substance
13.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
14.

Cerebral edema

Abnormal accumulation of fluid in the brain. [from HPO]

MedGen UID:
2337
Concept ID:
C0006114
Pathologic Function
15.

D-Hanks solution

MedGen UID:
828345
Concept ID:
C3851251
Organic Chemical; Pharmacologic Substance
16.

Aminobenzoates

Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure. [from MeSH]

MedGen UID:
501172
Concept ID:
C3495420
Organic Chemical; Pharmacologic Substance
17.

Metabolic Networks and Pathways

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. [from MeSH]

MedGen UID:
328456
Concept ID:
C1721099
Molecular Function
18.

Brain swelling

Abnormal accumulation of fluid in the brain. [from HPO]

MedGen UID:
315934
Concept ID:
C1527311
Pathologic Function
19.

Miccil

MedGen UID:
304516
Concept ID:
C1450761
Organic Chemical; Pharmacologic Substance
20.

Bumetanide Sensitive Na K Cl Transporter Inhibitors

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. [from MeSH]

MedGen UID:
288789
Concept ID:
C1563713
Pharmacologic Substance
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