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Items: 1 to 20 of 35

1.

Ryanodine

A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM. [from MeSH]

MedGen UID:
48522
Concept ID:
C0035983
Organic Chemical; Pharmacologic Substance
2.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
3.

Heart failure

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. [from MeSH]

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
4.

Calcium

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. [from MeSH]

MedGen UID:
710
Concept ID:
C0006675
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
5.

Heart Failure

MedGen UID:
880986
Concept ID:
CN236639
Disease or Syndrome
6.

Life Threatening

A situation that imperils the existence of an entity. [from NCI]

MedGen UID:
415288
Concept ID:
C2826244
Finding
7.

ECG abnormality

Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both. [from HPO]

MedGen UID:
321993
Concept ID:
C1832603
Finding
8.

Arrhythmia

An electrocardiographic finding of a change in cardiac electrical activity. [from NCI]

MedGen UID:
167788
Concept ID:
C0855329
Finding
9.

Ventricular arrhythmia

A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles. [from NCI]

MedGen UID:
39082
Concept ID:
C0085612
Disease or Syndrome; Finding
10.

Congestive heart failure

Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales. [from NCI]

MedGen UID:
9169
Concept ID:
C0018802
Disease or Syndrome
11.

Cardiac Death

The cessation of life due to heart abnormalities or disease. [from NCI]

MedGen UID:
91217
Concept ID:
C0376297
Pathologic Function
12.

Sudden cardiac death

An unexpected natural death from a cardiac cause within a short time period from the onset of symptoms.(NICHD) [from NCI]

MedGen UID:
38841
Concept ID:
C0085298
Pathologic Function
13.

Tachycardia

A rapid heartrate that exceeds the range of the normal resting heartrate for age. [from HPO]

MedGen UID:
21453
Concept ID:
C0039231
Finding; Finding; Pathologic Function
14.

Ventricular tachycardia

A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) [from NCI]

MedGen UID:
12068
Concept ID:
C0042514
Disease or Syndrome; Finding
15.

Epinephrine

The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. [from MeSH]

MedGen UID:
4993
Concept ID:
C0014563
Hormone; Organic Chemical; Pharmacologic Substance
16.

Caffeine

A methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity. [from NCI]

MedGen UID:
2403
Concept ID:
C0006644
Organic Chemical; Pharmacologic Substance
17.

Cardiac arrhythmia

A disorder in which there is abnormal electrical activity in the heart. [from SNOMEDCT_US]

MedGen UID:
2039
Concept ID:
C0003811
Finding; Finding
18.

Ventricular tachycardia

MedGen UID:
776567
Concept ID:
C2108113
Laboratory or Test Result
19.

Sudden cardiac death

MedGen UID:
369872
Concept ID:
C1968862
20.

Sustained ventricular tachycardia

An electrocardiographic finding of ventricular tachycardia greater than 30 seconds in duration. [from NCI]

MedGen UID:
155451
Concept ID:
C0750197
Disease or Syndrome
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