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MedGen UID:
Concept ID:
Organism Function
Synonyms: AGING
SNOMED CT: Aging (248280005)
OMIM®: 502000


Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

Recent systematic reviews

Carver LF, Buchanan D
Clin Interv Aging 2016 Nov 11;11:1623-1630. doi: 10.2147/CIA.S117202. PMID: 27956828Free PMC Article
Zhuang S, Wang HF, Wang X, Li J, Xing CM
J Clin Neurosci 2016 Nov;33:32-38. Epub 2016 Jul 27 doi: 10.1016/j.jocn.2016.02.036. PMID: 27475317
Gunes S, Hekim GN, Arslan MA, Asci R
J Assist Reprod Genet 2016 Apr;33(4):441-54. Epub 2016 Feb 11 doi: 10.1007/s10815-016-0663-y. PMID: 26867640Free PMC Article
Cohen AA
Biogerontology 2016 Feb;17(1):205-20. Epub 2015 May 20 doi: 10.1007/s10522-015-9584-x. PMID: 25991473Free PMC Article
Gonzalez-Freire M, de Cabo R, Bernier M, Sollott SJ, Fabbri E, Navas P, Ferrucci L
J Gerontol A Biol Sci Med Sci 2015 Nov;70(11):1334-42. Epub 2015 May 20 doi: 10.1093/gerona/glv070. PMID: 25995290Free PMC Article

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