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1.

Parathyroid carcinoma

The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor syndrome (HPT-JT). Parathyroid carcinoma. Familial isolated hyperparathyroidism (FIHP). Primary hyperparathyroidism, the main finding of HPT-JT syndrome, occurs in more than 70% of affected individuals; onset is typically in late adolescence or early adulthood. HPT-JT-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In approximately 10%-15% of cases, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Approximately 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign and malignant uterine tumors appear to be common in women with HPT-JT syndrome. [from GeneReviews]

MedGen UID:
146361
Concept ID:
C0687150
Neoplastic Process
2.

Parathyroid adenoma

A benign tumor of the parathyroid gland that can cause hyperparathyroidism. [from HPO]

MedGen UID:
75502
Concept ID:
C0262587
Neoplastic Process
3.

Hyperplasia

An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement. [from NCI]

MedGen UID:
43784
Concept ID:
C0020507
Pathologic Function
4.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus). [from HPO]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
5.

Adenoma

A benign neoplasm arising from epithelium. [from NCI_CDISC]

MedGen UID:
125
Concept ID:
C0001430
Neoplastic Process
6.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
7.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
8.

Epithelioma, malignant

MedGen UID:
639977
Concept ID:
C0553707
Neoplastic Process
9.

Parathyroid carcinoma

A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism. [from HPO]

MedGen UID:
505982
Concept ID:
CN005903
Finding
10.

Parathyroid adenoma

A benign tumor of the parathyroid gland that can cause hyperparathyroidism. [from HPO]

MedGen UID:
505395
Concept ID:
CN002620
Finding
11.

Cell Invasion

The movement of one cell type into an area normally occupied by a different cell type. [from NCI]

MedGen UID:
397081
Concept ID:
C2699153
Pathologic Function
12.

PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY

MedGen UID:
349287
Concept ID:
C1861457
Disease or Syndrome
13.

Neoplasm

A malignant tumor at the original site of growth. [from NCI]

MedGen UID:
227011
Concept ID:
C1306459
Neoplastic Process
14.

Benign Epithelial Neoplasm

A benign neoplasm arising from epithelial cells of the skin. [from NCI_CDISC]

MedGen UID:
90747
Concept ID:
C0334232
Neoplastic Process
15.

Parathyroid hyperplasia

Hyperplasia of the parathyroid gland. [from HPO]

MedGen UID:
75767
Concept ID:
C0271844
Disease or Syndrome
16.

Metastasis

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. [from MeSH]

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
17.

Tumorigenesis

A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation. [from NCI]

MedGen UID:
3302
Concept ID:
C0007621
Neoplastic Process
18.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
19.

Salivary Gland Monomorphic Adenoma

A benign epithelial neoplasm arising from the salivary glands. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

MedGen UID:
64421
Concept ID:
C0205649
Neoplastic Process
20.

Microcystic Adenoma

A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia. [from NCI]

MedGen UID:
64420
Concept ID:
C0205648
Neoplastic Process
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