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Items: 4

1.

Herpes simplex

Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV:. -HSV type 1 most commonly causes cold sores. It can also cause genital herpes. -HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.  [from MedlinePlus]

MedGen UID:
9234
Concept ID:
C0019348
Disease or Syndrome
2.

Herpes

Any inflammatory skin disease caused by a herpesvirus and characterized by the formation of small vesicles in clusters. [from NCI]

MedGen UID:
6821
Concept ID:
C0019340
Disease or Syndrome
3.

famciclovir

A diacetyl 6-deoxy prodrug analog of the antiviral agent penciclovir. Orally administered, famciclovir in vivo is converted to penciclovir triphosphate, which is active against the Herpes viruses, including herpes simplex 1 and 2 and varicella-zoster. This agent inhibits the replication of viral DNA by interfering competitively with DNA polymerase. (NCI04) [from NCI]

MedGen UID:
110886
Concept ID:
C0209227
Organic Chemical; Pharmacologic Substance
4.

penciclovir

A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. [from NCI]

MedGen UID:
103919
Concept ID:
C0164815
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
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