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Inducible T-Cell Co-Stimulator Protein

MedGen UID:
468364
Concept ID:
C3203085
Amino Acid, Peptide, or Protein; Biologically Active Substance; Immunologic Factor; Pharmacologic Substance
Synonyms: Activation Inducible Lymphocyte Immunomediatory Molecule; Activation-Inducible Lymphocyte Immunomediatory Molecule; Antigen, CD278; Antigens, CD278; CD278 Antigen; CD278 Antigens; Co-Stimulator, Inducible T-Cell; ICOS Inducible T Cell Co Stimulator; ICOS Inducible T-Cell Co-Stimulator; Inducible Co-Stimulator (ICOS); Inducible Costimulator (ICOS); Inducible T Cell Co Stimulator; Inducible T Cell Co Stimulator Protein; Inducible T-Cell Co-Stimulator; T-Cell Co-Stimulator, Inducible
 

Definition

A costimulatory receptor that is specific for INDUCIBLE T-CELL CO-STIMULATOR LIGAND. The receptor is associated with a diverse array of immunologically-related effects including the increased synthesis of INTERLEUKIN 10 in REGULATORY T-LYMPHOCYTES and the induction of PERIPHERAL TOLERANCE. [from MeSH]

Recent clinical studies

Etiology

Wang WM, Liu Z, Chen G
Genet Mol Res 2016 May 20;15(2) doi: 10.4238/gmr.15027338. PMID: 27323062
Berrón-Ruiz L, López-Herrera G, Vargas-Hernández A, Santos-Argumedo L, López-Macías C, Isibasi A, Segura-Méndez NH, Bonifaz L
Clin Immunol 2016 May;166-167:19-26. Epub 2016 Apr 4 doi: 10.1016/j.clim.2016.03.013. PMID: 27057998
Hedl M, Lahiri A, Ning K, Cho JH, Abraham C
Immunity 2014 May 15;40(5):734-46. doi: 10.1016/j.immuni.2014.04.011. PMID: 24837102Free PMC Article
Canaday DH, Parker KE, Aung H, Chen HE, Nunez-Medina D, Burant CJ
BMC Immunol 2013 Oct 1;14:45. doi: 10.1186/1471-2172-14-45. PMID: 24083425Free PMC Article
Faget J, Bendriss-Vermare N, Gobert M, Durand I, Olive D, Biota C, Bachelot T, Treilleux I, Goddard-Leon S, Lavergne E, Chabaud S, Blay JY, Caux C, Ménétrier-Caux C
Cancer Res 2012 Dec 1;72(23):6130-41. Epub 2012 Oct 1 doi: 10.1158/0008-5472.CAN-12-2409. PMID: 23026134

Diagnosis

Wilson P, Larminie C, Smith R
Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):101-110. Epub 2016 Oct 18 PMID: 27791955
Robertson N, Engelhardt KR, Morgan NV, Barge D, Cant AJ, Hughes SM, Abinun M, Xu Y, Koref MS, Arkwright PD, Hambleton S
J Clin Immunol 2015 Oct;35(7):598-603. Epub 2015 Sep 23 doi: 10.1007/s10875-015-0193-x. PMID: 26399252Free PMC Article
Vettermann C, Victor HP, Sun Y, Plewa C, Gupta S
J Immunol Methods 2015 Sep;424:14-9. Epub 2015 May 5 doi: 10.1016/j.jim.2015.04.015. PMID: 25956037
Cuzzola M, Fiasché M, Iacopino P, Messina G, Martino M, Console G, Fedele R, Massi D, Recchia AG, Irrera G, Morabito F
Haematologica 2012 Oct;97(10):1532-8. Epub 2012 Apr 4 doi: 10.3324/haematol.2011.059980. PMID: 22491736Free PMC Article
Ghourbani Gazar S, Andalib A, Hashemi M, Rezaei A
Iran J Immunol 2012 Mar;9(1):53-60. doi: IJIv9i1A5. PMID: 22426168

Therapy

Wang WM, Liu Z, Chen G
Genet Mol Res 2016 May 20;15(2) doi: 10.4238/gmr.15027338. PMID: 27323062
Chavele KM, Merry E, Ehrenstein MR
J Immunol 2015 Mar 15;194(6):2482-5. Epub 2015 Feb 13 doi: 10.4049/jimmunol.1401190. PMID: 25681343Free PMC Article
Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F
Immunity 2013 Mar 21;38(3):596-605. Epub 2013 Mar 14 doi: 10.1016/j.immuni.2012.11.020. PMID: 23499493
Cuzzola M, Fiasché M, Iacopino P, Messina G, Martino M, Console G, Fedele R, Massi D, Recchia AG, Irrera G, Morabito F
Haematologica 2012 Oct;97(10):1532-8. Epub 2012 Apr 4 doi: 10.3324/haematol.2011.059980. PMID: 22491736Free PMC Article
Atsukawa M, Nakatsuka K, Kobayashi T, Shimizu M, Tamura H, Harimoto H, Takahashi H, Sakamoto C
J Gastroenterol Hepatol 2012 Apr;27(4):823-31. doi: 10.1111/j.1440-1746.2011.06882.x. PMID: 21871023

Prognosis

Nagase H, Takeoka T, Urakawa S, Morimoto-Okazawa A, Kawashima A, Iwahori K, Takiguchi S, Nishikawa H, Sato E, Sakaguchi S, Mori M, Doki Y, Wada H
Int J Cancer 2017 Feb 1;140(3):686-695. Epub 2016 Oct 27 doi: 10.1002/ijc.30475. PMID: 27756099
Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J
Clin Exp Immunol 2016 Feb;183(2):294-306. Epub 2015 Nov 24 doi: 10.1111/cei.12715. PMID: 26415669Free PMC Article
Robertson N, Engelhardt KR, Morgan NV, Barge D, Cant AJ, Hughes SM, Abinun M, Xu Y, Koref MS, Arkwright PD, Hambleton S
J Clin Immunol 2015 Oct;35(7):598-603. Epub 2015 Sep 23 doi: 10.1007/s10875-015-0193-x. PMID: 26399252Free PMC Article
Faget J, Bendriss-Vermare N, Gobert M, Durand I, Olive D, Biota C, Bachelot T, Treilleux I, Goddard-Leon S, Lavergne E, Chabaud S, Blay JY, Caux C, Ménétrier-Caux C
Cancer Res 2012 Dec 1;72(23):6130-41. Epub 2012 Oct 1 doi: 10.1158/0008-5472.CAN-12-2409. PMID: 23026134
Cuzzola M, Fiasché M, Iacopino P, Messina G, Martino M, Console G, Fedele R, Massi D, Recchia AG, Irrera G, Morabito F
Haematologica 2012 Oct;97(10):1532-8. Epub 2012 Apr 4 doi: 10.3324/haematol.2011.059980. PMID: 22491736Free PMC Article

Clinical prediction guides

Nagase H, Takeoka T, Urakawa S, Morimoto-Okazawa A, Kawashima A, Iwahori K, Takiguchi S, Nishikawa H, Sato E, Sakaguchi S, Mori M, Doki Y, Wada H
Int J Cancer 2017 Feb 1;140(3):686-695. Epub 2016 Oct 27 doi: 10.1002/ijc.30475. PMID: 27756099
Berrón-Ruiz L, López-Herrera G, Vargas-Hernández A, Santos-Argumedo L, López-Macías C, Isibasi A, Segura-Méndez NH, Bonifaz L
Clin Immunol 2016 May;166-167:19-26. Epub 2016 Apr 4 doi: 10.1016/j.clim.2016.03.013. PMID: 27057998
Yu H, Zou X, Peng L, Wang Y, Zhang C, Chen B, Zou Y
DNA Cell Biol 2013 Dec;32(12):717-21. Epub 2013 Oct 1 doi: 10.1089/dna.2013.2127. PMID: 24083358Free PMC Article
Cuzzola M, Fiasché M, Iacopino P, Messina G, Martino M, Console G, Fedele R, Massi D, Recchia AG, Irrera G, Morabito F
Haematologica 2012 Oct;97(10):1532-8. Epub 2012 Apr 4 doi: 10.3324/haematol.2011.059980. PMID: 22491736Free PMC Article
Atsukawa M, Nakatsuka K, Kobayashi T, Shimizu M, Tamura H, Harimoto H, Takahashi H, Sakamoto C
J Gastroenterol Hepatol 2012 Apr;27(4):823-31. doi: 10.1111/j.1440-1746.2011.06882.x. PMID: 21871023

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