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Items: 13

1.

Demethylating Agent

Any agent that inhibits or prevents DNA methylation or agents that promote the removal of methyl groups from DNA. [from NCI]

MedGen UID:
1372482
Concept ID:
C4329713
Pharmacologic Substance
2.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
3.

Histone deacetylase inhibitor

Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation. [from NCI]

MedGen UID:
268200
Concept ID:
C1512474
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
4.

Vidaza

MedGen UID:
288801
Concept ID:
C1563756
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
6.

NSC-102816

MedGen UID:
209173
Concept ID:
C0878254
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
7.

DNA Methylation

The process by which methyl groups are added to nucleotides in genomic DNA. [from NCI]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
8.

Methylation

The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI) [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
9.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
10.

Azacitidine

A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent. [from MeSH]

MedGen UID:
467
Concept ID:
C0004475
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
11.

Disorder of hematopoietic structure

MedGen UID:
734977
Concept ID:
C1532235
Disease or Syndrome
12.

Osteoid formation disorder

MedGen UID:
533867
Concept ID:
C0231554
Disease or Syndrome
13.

Congenital anomaly of cartilage

Any dysfunction in the growth of cartilage. [from NCI]

MedGen UID:
935
Concept ID:
C0008449
Disease or Syndrome
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