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Items: 17

1.

Depression

MedGen UID:
881016
Concept ID:
CN236657
Disease or Syndrome
2.

Abnormality of the cerebral white matter

Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS. [from MeSH]

MedGen UID:
181756
Concept ID:
C0948163
Pathologic Function
3.

Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include : -Sadness. -Loss of interest or pleasure in activities you used to enjoy. -Change in weight. -Difficulty sleeping or oversleeping. -Energy loss. -Feelings of worthlessness. -Thoughts of death or suicide. Depression is a disorder of the brain. There are a variety of causes, including genetic, environmental, psychological, and biochemical factors. Depression usually starts between the ages of 15 and 30, and is much more common in women. Women can also get postpartum depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder. There are effective treatments for depression, including antidepressants and talk therapy. Most people do best by using both. . NIH: National Institute of Mental Health.  [from MedlinePlus]

MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
4.

Deep cerebral white matter hyperdensities

Areas of brighter than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter. [from HPO]

MedGen UID:
892385
Concept ID:
CN238368
Finding
5.

Depressive Disorder

MedGen UID:
881121
Concept ID:
CN236658
Disease or Syndrome
6.

White matter hyperintensities

MedGen UID:
811125
Concept ID:
C2938912
Pathologic Function
7.

Major depressive disorder

Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation. [from MeSH]

MedGen UID:
266123
Concept ID:
C1269683
Mental or Behavioral Dysfunction
8.

Leukoencephalopathy

Any of various diseases affecting the white matter of the central nervous system. [from MeSH]

MedGen UID:
78722
Concept ID:
C0270612
Disease or Syndrome
9.

Unspecified encephalopathy

Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state. [from HPO]

MedGen UID:
39314
Concept ID:
C0085584
Disease or Syndrome
10.

Mental disorder

Mental disorders include a wide range of problems, including. -Anxiety disorders, including panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and phobias. -Bipolar disorder. -Depression. -Mood disorders. -Personality disorders. -Psychotic disorders, including schizophrenia. There are many causes of mental disorders. Your genes and family history may play a role. Your life experiences, such as stress or a history of abuse, may also matter. Biological factors can also be part of the cause. A traumatic brain injury can lead to a mental disorder. A mother's exposure to viruses or toxic chemicals while pregnant may play a part. Other factors may increase your risk, such as use of illegal drugs or having a serious medical condition like cancer. Medications and counseling can help many mental disorders. .  [from MedlinePlus]

MedGen UID:
14047
Concept ID:
C0004936
Mental or Behavioral Dysfunction
11.

Morphological abnormality of the central nervous system

A structural abnormality of the central nervous system. [from HPO]

MedGen UID:
3306
Concept ID:
C0007682
Disease or Syndrome
12.

Changes in white matter of brain

MedGen UID:
851710
Concept ID:
CN233054
Finding
13.

Cortical malformations, occipital

Occipital cortical malformations (OCCM) is an autosomal recessive condition in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes. Three patients have been reported (summary by Barak et al., 2011). [from OMIM]

MedGen UID:
481505
Concept ID:
C3279875
Disease or Syndrome
14.

Cerebral white matter agenesis

Congenital defect with failure of the development of the cerebral white matter. [from HPO]

MedGen UID:
452073
Concept ID:
CN117758
Finding
15.

Agenesis of cerebral white matter

Congenital defect with failure of the development of the cerebral white matter. [from HPO]

MedGen UID:
347986
Concept ID:
C1859969
Finding; Pathologic Function
16.

Hypoplasia of the frontal lobes

Underdevelopment of the frontal lobe of the cerebrum. [from HPO]

MedGen UID:
341396
Concept ID:
C1849172
Finding
17.

Small cerebral cortex

Reduced size of the cerebral cortex. [from HPO]

MedGen UID:
325187
Concept ID:
C1837503
Finding
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