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Anticoagulants

MedGen UID:
1970
Concept ID:
C0003280
Pharmacologic Substance
Synonyms: Agents, Anticoagulant; Agents, Anticoagulation; Anticoagulant; Anticoagulant Agents; Anticoagulant Drugs; Anticoagulation Agents; Drugs, Anticoagulant
SNOMED CT: Anticoagulant (372862008); Anticoagulant (81839001); Anticoagulant drug (81839001)
 

Definition

If you have some kinds of heart or blood vessel disease, or if you have poor blood flow to your brain, your doctor may recommend that you take a blood thinner. Blood thinners reduce the risk of heart attack and stroke by reducing the formation of blood clots in your arteries and veins. You may also take a blood thinner if you have . -An abnormal heart rhythm called atrial fibrillation. -Heart valve surgery. -Congenital heart defects. There are two main types of blood thinners. Anticoagulants, such as heparin or warfarin (also called Coumadin), work on chemical reactions in your body to lengthen the time it takes to form a blood clot. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. When you take a blood thinner, follow directions carefully. Make sure that your healthcare provider knows all of the medicines and supplements you are using.  [from MedlinePlus]

Recent clinical studies

Etiology

Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, Wang B, Li Z
Medicine (Baltimore) 2017 Apr;96(16):e6646. doi: 10.1097/MD.0000000000006646. PMID: 28422866Free PMC Article
Renda G, Ricci F, De Caterina R
Am J Med 2017 Apr;130(4):457-461. Epub 2016 Oct 15 doi: 10.1016/j.amjmed.2016.09.023. PMID: 27751896
Stein PD, Matta F, Hughes PG, Hourmouzis ZN, Hourmouzis NP, White RM, Ghiardi MM, Schwartz MA, Moore HL, Bach JA, Schweiss RE, Kazan VM, Kakish EJ, Keyes DC, Hughes MJ
Am J Med 2016 Sep;129(9):974-7. Epub 2016 Apr 21 doi: 10.1016/j.amjmed.2016.03.035. PMID: 27107921
Shah A, Shewale A, Hayes CJ, Martin BC
Stroke 2016 Jun;47(6):1555-61. Epub 2016 Apr 21 doi: 10.1161/STROKEAHA.115.012325. PMID: 27103018
Senger S, Keiner D, Hendrix P, Oertel J
World Neurosurg 2016 Apr;88:132-9. Epub 2015 Dec 28 doi: 10.1016/j.wneu.2015.11.086. PMID: 26732970

Diagnosis

Purrucker JC, Haas K, Rizos T, Khan S, Poli S, Kraft P, Kleinschnitz C, Dziewas R, Binder A, Palm F, Jander S, Soda H, Heuschmann PU, Veltkamp R; RASUNOA Investigators (Registry of Acute Stroke Under New Oral Anticoagulants).
Stroke 2017 Jan;48(1):152-158. Epub 2016 Nov 29 doi: 10.1161/STROKEAHA.116.014963. PMID: 27899756
Rankin J, Nagar M, Crosby J, Toomari N, Pietras R, Ben-Zur UM
J Med Case Rep 2016 Dec 3;10(1):346. doi: 10.1186/s13256-016-1135-9. PMID: 27912791Free PMC Article
Stein PD, Matta F, Hughes PG, Hourmouzis ZN, Hourmouzis NP, White RM, Ghiardi MM, Schwartz MA, Moore HL, Bach JA, Schweiss RE, Kazan VM, Kakish EJ, Keyes DC, Hughes MJ
Am J Med 2016 Sep;129(9):974-7. Epub 2016 Apr 21 doi: 10.1016/j.amjmed.2016.03.035. PMID: 27107921
Shah A, Shewale A, Hayes CJ, Martin BC
Stroke 2016 Jun;47(6):1555-61. Epub 2016 Apr 21 doi: 10.1161/STROKEAHA.115.012325. PMID: 27103018
Senger S, Keiner D, Hendrix P, Oertel J
World Neurosurg 2016 Apr;88:132-9. Epub 2015 Dec 28 doi: 10.1016/j.wneu.2015.11.086. PMID: 26732970

Therapy

Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, Wang B, Li Z
Medicine (Baltimore) 2017 Apr;96(16):e6646. doi: 10.1097/MD.0000000000006646. PMID: 28422866Free PMC Article
Renda G, Ricci F, De Caterina R
Am J Med 2017 Apr;130(4):457-461. Epub 2016 Oct 15 doi: 10.1016/j.amjmed.2016.09.023. PMID: 27751896
Stein PD, Matta F, Hughes PG, Hourmouzis ZN, Hourmouzis NP, White RM, Ghiardi MM, Schwartz MA, Moore HL, Bach JA, Schweiss RE, Kazan VM, Kakish EJ, Keyes DC, Hughes MJ
Am J Med 2016 Sep;129(9):974-7. Epub 2016 Apr 21 doi: 10.1016/j.amjmed.2016.03.035. PMID: 27107921
Shah A, Shewale A, Hayes CJ, Martin BC
Stroke 2016 Jun;47(6):1555-61. Epub 2016 Apr 21 doi: 10.1161/STROKEAHA.115.012325. PMID: 27103018
Senger S, Keiner D, Hendrix P, Oertel J
World Neurosurg 2016 Apr;88:132-9. Epub 2015 Dec 28 doi: 10.1016/j.wneu.2015.11.086. PMID: 26732970

Prognosis

Zhang JY, Wang YB, Gong JP, Zhang F, Zhao Y
Am Surg 2016 Dec 1;82(12):1169-1177. PMID: 28234180
Cappellari M, Carletti M, Danese A, Bovi P
J Thromb Thrombolysis 2016 Oct;42(3):393-8. doi: 10.1007/s11239-016-1393-9. PMID: 27329483
Betancur JF, Bonilla-Abadía F, Hormaza AA, Jaramillo FJ, Cañas CA, Tobón GJ
Lupus 2016 May;25(6):658-62. Epub 2016 Jan 6 doi: 10.1177/0961203315624555. PMID: 26743321
Senger S, Keiner D, Hendrix P, Oertel J
World Neurosurg 2016 Apr;88:132-9. Epub 2015 Dec 28 doi: 10.1016/j.wneu.2015.11.086. PMID: 26732970
Seiffge DJ, Hooff RJ, Nolte CH, Béjot Y, Turc G, Ikenberg B, Berge E, Persike M, Dequatre-Ponchelle N, Strbian D, Pfeilschifter W, Zini A, Tveiten A, Næss H, Michel P, Sztajzel R, Luft A, Gensicke H, Traenka C, Hert L, Scheitz JF, De Marchis GM, Bonati LH, Peters N, Charidimou A, Werring DJ, Palm F, Reinhard M, Niesen WD, Nagao T, Pezzini A, Caso V, Nederkoorn PJ, Kägi G, von Hessling A, Padjen V, Cordonnier C, Erdur H, Lyrer PA, Brouns R, Steiner T, Tatlisumak T, Engelter ST; NOACISP Study Group*.
Circulation 2015 Sep 29;132(13):1261-9. Epub 2015 Jul 31 doi: 10.1161/CIRCULATIONAHA.115.015484. PMID: 26232277

Clinical prediction guides

Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, Wang B, Li Z
Medicine (Baltimore) 2017 Apr;96(16):e6646. doi: 10.1097/MD.0000000000006646. PMID: 28422866Free PMC Article
Purrucker JC, Haas K, Rizos T, Khan S, Poli S, Kraft P, Kleinschnitz C, Dziewas R, Binder A, Palm F, Jander S, Soda H, Heuschmann PU, Veltkamp R; RASUNOA Investigators (Registry of Acute Stroke Under New Oral Anticoagulants).
Stroke 2017 Jan;48(1):152-158. Epub 2016 Nov 29 doi: 10.1161/STROKEAHA.116.014963. PMID: 27899756
Renda G, Ricci F, De Caterina R
Am J Med 2017 Apr;130(4):457-461. Epub 2016 Oct 15 doi: 10.1016/j.amjmed.2016.09.023. PMID: 27751896
Stein PD, Matta F, Hughes PG, Hourmouzis ZN, Hourmouzis NP, White RM, Ghiardi MM, Schwartz MA, Moore HL, Bach JA, Schweiss RE, Kazan VM, Kakish EJ, Keyes DC, Hughes MJ
Am J Med 2016 Sep;129(9):974-7. Epub 2016 Apr 21 doi: 10.1016/j.amjmed.2016.03.035. PMID: 27107921
Shah A, Shewale A, Hayes CJ, Martin BC
Stroke 2016 Jun;47(6):1555-61. Epub 2016 Apr 21 doi: 10.1161/STROKEAHA.115.012325. PMID: 27103018

Recent systematic reviews

Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, Wang B, Li Z
Medicine (Baltimore) 2017 Apr;96(16):e6646. doi: 10.1097/MD.0000000000006646. PMID: 28422866Free PMC Article
Renda G, Ricci F, De Caterina R
Am J Med 2017 Apr;130(4):457-461. Epub 2016 Oct 15 doi: 10.1016/j.amjmed.2016.09.023. PMID: 27751896
Zhang JY, Wang YB, Gong JP, Zhang F, Zhao Y
Am Surg 2016 Dec 1;82(12):1169-1177. PMID: 28234180
Heidbuchel H, Verhamme P, Alings M, Antz M, Diener HC, Hacke W, Oldgren J, Sinnaeve P, Camm AJ, Kirchhof P
Europace 2015 Oct;17(10):1467-507. Epub 2015 Aug 31 doi: 10.1093/europace/euv309. PMID: 26324838
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. PMID: 25855702

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