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Dopamine

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
Synonyms: 1,2-Benzenediol, 4-(2-aminoethyl)-; 3,4 Dihydroxyphenethylamine; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Hydroxytyramine
SNOMED CT: Dopamine product (59187003); Dopamine (412383006); Dopamine preparation (412383006); Dopamine agent (412383006); Dopamine (59187003); Hydroxytyramine (59187003)
 

Definition

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

Recent clinical studies

Etiology

Zhou X, Pardue MT, Iuvone PM, Qu J
Prog Retin Eye Res 2017 Nov;61:60-71. Epub 2017 Jun 7 doi: 10.1016/j.preteyeres.2017.06.003. PMID: 28602573Free PMC Article
Caminiti SP, Presotto L, Baroncini D, Garibotto V, Moresco RM, Gianolli L, Volonté MA, Antonini A, Perani D
Neuroimage Clin 2017;14:734-740. Epub 2017 Mar 27 doi: 10.1016/j.nicl.2017.03.011. PMID: 28409113Free PMC Article
Schnuelle P, Schmitt WH, Weiss C, Habicht A, Renders L, Zeier M, Drüschler F, Heller K, Pisarski P, Banas B, Krämer BK, Jung M, Lopau K, Olbricht CJ, Weihprecht H, Schenker P, De Fijter JW, Yard BA, Benck U
Clin J Am Soc Nephrol 2017 Mar 7;12(3):493-501. Epub 2017 Feb 17 doi: 10.2215/CJN.07600716. PMID: 28213388Free PMC Article
Talemi RP, Mousavi SM, Afruzi H
Mater Sci Eng C Mater Biol Appl 2017 Apr 1;73:700-708. Epub 2016 Dec 26 doi: 10.1016/j.msec.2016.12.119. PMID: 28183663
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article

Diagnosis

Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD
JAMA Psychiatry 2017 Dec 1;74(12):1206-1213. doi: 10.1001/jamapsychiatry.2017.2943. PMID: 29049482
Levite M, Marino F, Cosentino M
J Neural Transm (Vienna) 2017 May;124(5):525-542. Epub 2017 Mar 10 doi: 10.1007/s00702-016-1640-4. PMID: 28283756
Talemi RP, Mousavi SM, Afruzi H
Mater Sci Eng C Mater Biol Appl 2017 Apr 1;73:700-708. Epub 2016 Dec 26 doi: 10.1016/j.msec.2016.12.119. PMID: 28183663
Rehmani N, Zafar A, Arif H, Hadi SM, Wani AA
Toxicol In Vitro 2017 Apr;40:336-346. Epub 2017 Jan 28 doi: 10.1016/j.tiv.2017.01.020. PMID: 28137434Free PMC Article
Matsuda Y, Kimura N, Yoshimoto T, Sekiguchi Y, Tomoishi J, Kasahara I, Hara Y, Ogawa Y
Endocr Pathol 2017 Mar;28(1):36-40. doi: 10.1007/s12022-016-9457-0. PMID: 27743246

Therapy

Zhou X, Pardue MT, Iuvone PM, Qu J
Prog Retin Eye Res 2017 Nov;61:60-71. Epub 2017 Jun 7 doi: 10.1016/j.preteyeres.2017.06.003. PMID: 28602573Free PMC Article
Levite M, Marino F, Cosentino M
J Neural Transm (Vienna) 2017 May;124(5):525-542. Epub 2017 Mar 10 doi: 10.1007/s00702-016-1640-4. PMID: 28283756
Schnuelle P, Schmitt WH, Weiss C, Habicht A, Renders L, Zeier M, Drüschler F, Heller K, Pisarski P, Banas B, Krämer BK, Jung M, Lopau K, Olbricht CJ, Weihprecht H, Schenker P, De Fijter JW, Yard BA, Benck U
Clin J Am Soc Nephrol 2017 Mar 7;12(3):493-501. Epub 2017 Feb 17 doi: 10.2215/CJN.07600716. PMID: 28213388Free PMC Article
Yang X, Sun X, Chen H, Xi G, Hou Y, Wu J, Liu D, Wang H, Hou Y, Yu J
Int Immunopharmacol 2017 Apr;45:68-73. Epub 2017 Feb 8 doi: 10.1016/j.intimp.2017.02.002. PMID: 28189055
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article

Prognosis

Zhou X, Pardue MT, Iuvone PM, Qu J
Prog Retin Eye Res 2017 Nov;61:60-71. Epub 2017 Jun 7 doi: 10.1016/j.preteyeres.2017.06.003. PMID: 28602573Free PMC Article
Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang GJ, Fowler JS, Volkow ND
J Neurosci 2017 May 10;37(19):4982-4991. Epub 2017 Apr 17 doi: 10.1523/JNEUROSCI.3155-16.2017. PMID: 28416594Free PMC Article
Schnuelle P, Schmitt WH, Weiss C, Habicht A, Renders L, Zeier M, Drüschler F, Heller K, Pisarski P, Banas B, Krämer BK, Jung M, Lopau K, Olbricht CJ, Weihprecht H, Schenker P, De Fijter JW, Yard BA, Benck U
Clin J Am Soc Nephrol 2017 Mar 7;12(3):493-501. Epub 2017 Feb 17 doi: 10.2215/CJN.07600716. PMID: 28213388Free PMC Article
Hao F, Wang S, Zhu X, Xue J, Li J, Wang L, Li J, Lu W, Zhou T
Pharm Res 2017 Feb;34(2):408-418. Epub 2016 Dec 14 doi: 10.1007/s11095-016-2071-5. PMID: 27975187
Maia TV, Frank MJ
Biol Psychiatry 2017 Jan 1;81(1):52-66. Epub 2016 Jun 1 doi: 10.1016/j.biopsych.2016.05.021. PMID: 27452791Free PMC Article

Clinical prediction guides

Zhou X, Pardue MT, Iuvone PM, Qu J
Prog Retin Eye Res 2017 Nov;61:60-71. Epub 2017 Jun 7 doi: 10.1016/j.preteyeres.2017.06.003. PMID: 28602573Free PMC Article
Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang GJ, Fowler JS, Volkow ND
J Neurosci 2017 May 10;37(19):4982-4991. Epub 2017 Apr 17 doi: 10.1523/JNEUROSCI.3155-16.2017. PMID: 28416594Free PMC Article
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article
Matsuda Y, Kimura N, Yoshimoto T, Sekiguchi Y, Tomoishi J, Kasahara I, Hara Y, Ogawa Y
Endocr Pathol 2017 Mar;28(1):36-40. doi: 10.1007/s12022-016-9457-0. PMID: 27743246
Feng XY, Zhang DN, Wang YA, Fan RF, Hong F, Zhang Y, Li Y, Zhu JX
Acta Physiol (Oxf) 2017 May;220(1):113-123. Epub 2016 Oct 6 doi: 10.1111/apha.12806. PMID: 27652590

Recent systematic reviews

Kaasinen V, Vahlberg T
Ann Neurol 2017 Dec;82(6):873-882. Epub 2017 Dec 5 doi: 10.1002/ana.25103. PMID: 29165839
Rui Q, Jiang Y, Chen M, Zhang N, Yang H, Zhou Y
Medicine (Baltimore) 2017 Oct;96(43):e8402. doi: 10.1097/MD.0000000000008402. PMID: 29069037Free PMC Article
Karrer TM, Josef AK, Mata R, Morris ED, Samanez-Larkin GR
Neurobiol Aging 2017 Sep;57:36-46. Epub 2017 May 12 doi: 10.1016/j.neurobiolaging.2017.05.006. PMID: 28599217Free PMC Article
Abraham AD, Neve KA, Lattal KM
Neurobiol Learn Mem 2014 Feb;108:65-77. Epub 2013 Nov 20 doi: 10.1016/j.nlm.2013.11.007. PMID: 24269353Free PMC Article
Padmanabhan A, Luna B
Brain Cogn 2014 Aug;89:27-38. Epub 2013 Oct 17 doi: 10.1016/j.bandc.2013.09.011. PMID: 24139694Free PMC Article

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