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Perifosine

MedGen UID:
199998
Concept ID:
C0754570
Organic Chemical; Pharmacologic Substance
Synonyms: octadecyl-(1,1-dimethyl-4-piperidylio)phosphate; perifosine
 

Definition

An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. (NCI04) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerifosine

Recent clinical studies

Etiology

Kushner BH, Cheung NV, Modak S, Becher OJ, Basu EM, Roberts SS, Kramer K, Dunkel IJ
Int J Cancer 2017 Jan 15;140(2):480-484. Epub 2016 Sep 30 doi: 10.1002/ijc.30440. PMID: 27649927Free PMC Article
Gojo I, Perl A, Luger S, Baer MR, Norsworthy KJ, Bauer KS, Tidwell M, Fleckinger S, Carroll M, Sausville EA
Invest New Drugs 2013 Oct;31(5):1217-27. Epub 2013 Feb 27 doi: 10.1007/s10637-013-9937-8. PMID: 23443507Free PMC Article
Cho DC, Hutson TE, Samlowski W, Sportelli P, Somer B, Richards P, Sosman JA, Puzanov I, Michaelson MD, Flaherty KT, Figlin RA, Vogelzang NJ
Cancer 2012 Dec 15;118(24):6055-62. Epub 2012 Jun 6 doi: 10.1002/cncr.27668. PMID: 22674198Free PMC Article
Gao Y, Ishiyama H, Sun M, Brinkman KL, Wang X, Zhu J, Mai W, Huang Y, Floryk D, Ittmann M, Thompson TC, Butler EB, Xu B, Teh BS
Radiat Oncol 2011 Apr 15;6:39. doi: 10.1186/1748-717X-6-39. PMID: 21496273Free PMC Article
Li Z, Tan F, Liewehr DJ, Steinberg SM, Thiele CJ
J Natl Cancer Inst 2010 Jun 2;102(11):758-70. Epub 2010 May 12 doi: 10.1093/jnci/djq125. PMID: 20463309Free PMC Article

Diagnosis

Becher OJ, Millard NE, Modak S, Kushner BH, Haque S, Spasojevic I, Trippett TM, Gilheeney SW, Khakoo Y, Lyden DC, De Braganca KC, Kolesar JM, Huse JT, Kramer K, Cheung NV, Dunkel IJ
PLoS One 2017;12(6):e0178593. Epub 2017 Jun 5 doi: 10.1371/journal.pone.0178593. PMID: 28582410Free PMC Article
Egler J, Lang F
Cell Physiol Biochem 2017;41(6):2534-2544. Epub 2017 May 4 doi: 10.1159/000475977. PMID: 28472790
Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM
Clin Cancer Res 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19 doi: 10.1158/1078-0432.CCR-14-0770. PMID: 25239609
Qin LS, Yu ZQ, Zhang SM, Sun G, Zhu J, Xu J, Guo J, Fu LS
Mol Biol Rep 2013 Oct;40(10):5645-55. Epub 2013 Sep 25 doi: 10.1007/s11033-013-2666-4. PMID: 24065522
Al Sawah E, Chen X, Marchion DC, Xiong Y, Ramirez IJ, Abbasi F, Bou Zgheib N, Chon HS, Wenham RM, Apte SM, Judson PL, Lancaster JM
Gynecol Oncol 2013 Oct;131(1):207-12. Epub 2013 Jul 20 doi: 10.1016/j.ygyno.2013.07.088. PMID: 23877012

Therapy

Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH, Kramer K, Spasojevic I, Dunkel IJ
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 30 doi: 10.1002/pbc.26409. PMID: 28035748
Shen J, Xu L, Zhao Q
Biochem Biophys Res Commun 2016 May 13;473(4):1170-1176. Epub 2016 Apr 9 doi: 10.1016/j.bbrc.2016.04.035. PMID: 27073162
Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW
Oncotarget 2015 Sep 8;6(26):21816-26. doi: 10.18632/oncotarget.5200. PMID: 26307677Free PMC Article
Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM
Clin Cancer Res 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19 doi: 10.1158/1078-0432.CCR-14-0770. PMID: 25239609
Figg WD, Monga M, Headlee D, Shah A, Chau CH, Peer C, Messman R, Elsayed YA, Murgo AJ, Melillo G, Ryan QC, Kalnitskiy M, Senderowicz AM, Hollingshead M, Arbuck SG, Sausville EA
Cancer Chemother Pharmacol 2014 Nov;74(5):955-67. Epub 2014 Sep 3 doi: 10.1007/s00280-014-2569-7. PMID: 25183650

Prognosis

Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM
Clin Cancer Res 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19 doi: 10.1158/1078-0432.CCR-14-0770. PMID: 25239609
Liu D, Sun Q, Liang S, Xu L, Luo X, Zhao X, Wang X, Yang L
Mol Med Rep 2013 Feb;7(2):642-8. Epub 2012 Nov 21 doi: 10.3892/mmr.2012.1191. PMID: 23175237
Yao C, Wei JJ, Wang ZY, Ding HM, Li D, Yan SC, Yang YJ, Gu ZP
Cell Biochem Biophys 2013 Mar;65(2):217-27. doi: 10.1007/s12013-012-9423-5. PMID: 23015227
Cho DC, Hutson TE, Samlowski W, Sportelli P, Somer B, Richards P, Sosman JA, Puzanov I, Michaelson MD, Flaherty KT, Figlin RA, Vogelzang NJ
Cancer 2012 Dec 15;118(24):6055-62. Epub 2012 Jun 6 doi: 10.1002/cncr.27668. PMID: 22674198Free PMC Article
Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X, Azab F, Azab AK, Rodig S, Warren D, Harris B, Varticovski L, Sportelli P, Leleu X, Anderson KC, Richardson PG
Clin Cancer Res 2010 Feb 1;16(3):1033-41. Epub 2010 Jan 26 doi: 10.1158/1078-0432.CCR-09-1837. PMID: 20103671Free PMC Article

Clinical prediction guides

Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH, Kramer K, Spasojevic I, Dunkel IJ
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 30 doi: 10.1002/pbc.26409. PMID: 28035748
Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM
Clin Cancer Res 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19 doi: 10.1158/1078-0432.CCR-14-0770. PMID: 25239609
Figg WD, Monga M, Headlee D, Shah A, Chau CH, Peer C, Messman R, Elsayed YA, Murgo AJ, Melillo G, Ryan QC, Kalnitskiy M, Senderowicz AM, Hollingshead M, Arbuck SG, Sausville EA
Cancer Chemother Pharmacol 2014 Nov;74(5):955-67. Epub 2014 Sep 3 doi: 10.1007/s00280-014-2569-7. PMID: 25183650
Qin LS, Yu ZQ, Zhang SM, Sun G, Zhu J, Xu J, Guo J, Fu LS
Mol Biol Rep 2013 Oct;40(10):5645-55. Epub 2013 Sep 25 doi: 10.1007/s11033-013-2666-4. PMID: 24065522
Srivastava N, Cho DC
Expert Opin Investig Drugs 2013 Feb;22(2):285-91. Epub 2012 Dec 20 doi: 10.1517/13543784.2013.754422. PMID: 23253151

Recent systematic reviews

Vink SR, van Blitterswijk WJ, Schellens JH, Verheij M
Cancer Treat Rev 2007 Apr;33(2):191-202. Epub 2007 Feb 6 doi: 10.1016/j.ctrv.2006.12.001. PMID: 17287087

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