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Aspirin

MedGen UID:
2104
Concept ID:
C0004057
Organic Chemical; Pharmacologic Substance
Synonyms: 2-(Acetyloxy)benzoic Acid; Acetylsalicylic Acid; Acid, Acetylsalicylic; Benzoic acid, 2-(acetyloxy)-
SNOMED CT: Acetylsalicylic acid (7947003); Aspirin (7947003); Aspirin (387458008); Acetylsalicylic acid (387458008)
 

Definition

An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39152&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39152&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C287" NCI Thesaurus) [from PDQ]

Recent clinical studies

Etiology

Zhang JW, Liu TF, Chen XH, Liang WY, Feng XR, Wang L, Fu SW, McCaffrey TA, Liu ML
Gene 2017 Aug 15;624:56-65. Epub 2017 Apr 28 doi: 10.1016/j.gene.2017.04.041. PMID: 28457985
Phan K, Moore JM, Griessenauer CJ, Ogilvy CS, Thomas AJ
Stroke 2017 May;48(5):1210-1217. Epub 2017 Mar 24 doi: 10.1161/STROKEAHA.116.015674. PMID: 28341753
Snyder MA, Sympson AN, Scheuerman CM, Gregg JL, Hussain LR
J Arthroplasty 2017 May;32(5):1478-1482. Epub 2016 Dec 23 doi: 10.1016/j.arth.2016.12.027. PMID: 28159420
Mc Menamin ÚC, Cardwell CR, Hughes CM, Murray LJ
Cancer Epidemiol 2017 Apr;47:20-27. Epub 2017 Jan 12 doi: 10.1016/j.canep.2016.12.008. PMID: 28088656
Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E
Am J Obstet Gynecol 2017 Feb;216(2):110-120.e6. Epub 2016 Sep 15 doi: 10.1016/j.ajog.2016.09.076. PMID: 27640943

Diagnosis

Mc Menamin ÚC, Cardwell CR, Hughes CM, Murray LJ
Cancer Epidemiol 2017 Apr;47:20-27. Epub 2017 Jan 12 doi: 10.1016/j.canep.2016.12.008. PMID: 28088656
Wang Y, Minematsu K, Wong KS, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Molina CA, Johnston SC; SOCRATES Steering Committee and Investigators.
Stroke 2017 Jan;48(1):167-173. Epub 2016 Nov 29 doi: 10.1161/STROKEAHA.116.014891. PMID: 27899747
Walgama ES, Hwang PH
Otolaryngol Clin North Am 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007. PMID: 27888917
So CH, Eckman MH
J Thromb Thrombolysis 2017 Jan;43(1):7-17. doi: 10.1007/s11239-016-1425-5. PMID: 27665101Free PMC Article
Brenner T, Schmitt FC, Demirel S, Salgado E, Celi de la Torre JA, Göring M, Bruckner T, Böckler D, Weigand MA, Hofer S, Attigah N
Vascular 2017 Feb;25(1):19-27. Epub 2016 Jul 9 doi: 10.1177/1708538116638961. PMID: 26993144

Therapy

Zhang JW, Liu TF, Chen XH, Liang WY, Feng XR, Wang L, Fu SW, McCaffrey TA, Liu ML
Gene 2017 Aug 15;624:56-65. Epub 2017 Apr 28 doi: 10.1016/j.gene.2017.04.041. PMID: 28457985
Phan K, Moore JM, Griessenauer CJ, Ogilvy CS, Thomas AJ
Stroke 2017 May;48(5):1210-1217. Epub 2017 Mar 24 doi: 10.1161/STROKEAHA.116.015674. PMID: 28341753
Snyder MA, Sympson AN, Scheuerman CM, Gregg JL, Hussain LR
J Arthroplasty 2017 May;32(5):1478-1482. Epub 2016 Dec 23 doi: 10.1016/j.arth.2016.12.027. PMID: 28159420
Mc Menamin ÚC, Cardwell CR, Hughes CM, Murray LJ
Cancer Epidemiol 2017 Apr;47:20-27. Epub 2017 Jan 12 doi: 10.1016/j.canep.2016.12.008. PMID: 28088656
Koh JS, Park Y, Tantry US, Ahn JH, Kang MG, Kim K, Jang JY, Park HW, Park JR, Hwang SJ, Kwak CH, Hwang JY, Gurbel PA, Jeong YH
Platelets 2017 Mar;28(2):187-193. Epub 2016 Aug 25 doi: 10.1080/09537104.2016.1206197. PMID: 27560946

Prognosis

Zhang JW, Liu TF, Chen XH, Liang WY, Feng XR, Wang L, Fu SW, McCaffrey TA, Liu ML
Gene 2017 Aug 15;624:56-65. Epub 2017 Apr 28 doi: 10.1016/j.gene.2017.04.041. PMID: 28457985
Mc Menamin ÚC, Cardwell CR, Hughes CM, Murray LJ
Cancer Epidemiol 2017 Apr;47:20-27. Epub 2017 Jan 12 doi: 10.1016/j.canep.2016.12.008. PMID: 28088656
van Diepen S, Fuster V, Verma S, Hamza TH, Siami FS, Goodman SG, Farkouh ME
J Am Coll Cardiol 2017 Jan 17;69(2):119-127. doi: 10.1016/j.jacc.2016.10.043. PMID: 28081820
Saito Y, Okada S, Ogawa H, Soejima H, Sakuma M, Nakayama M, Doi N, Jinnouchi H, Waki M, Masuda I, Morimoto T; JPAD Trial Investigators.
Circulation 2017 Feb 14;135(7):659-670. Epub 2016 Nov 15 doi: 10.1161/CIRCULATIONAHA.116.025760. PMID: 27881565
Brenner T, Schmitt FC, Demirel S, Salgado E, Celi de la Torre JA, Göring M, Bruckner T, Böckler D, Weigand MA, Hofer S, Attigah N
Vascular 2017 Feb;25(1):19-27. Epub 2016 Jul 9 doi: 10.1177/1708538116638961. PMID: 26993144

Clinical prediction guides

Zhang JW, Liu TF, Chen XH, Liang WY, Feng XR, Wang L, Fu SW, McCaffrey TA, Liu ML
Gene 2017 Aug 15;624:56-65. Epub 2017 Apr 28 doi: 10.1016/j.gene.2017.04.041. PMID: 28457985
van Diepen S, Fuster V, Verma S, Hamza TH, Siami FS, Goodman SG, Farkouh ME
J Am Coll Cardiol 2017 Jan 17;69(2):119-127. doi: 10.1016/j.jacc.2016.10.043. PMID: 28081820
Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES
Biochem Biophys Res Commun 2017 Jan 8;482(2):346-351. Epub 2016 Nov 14 doi: 10.1016/j.bbrc.2016.11.066. PMID: 27856258Free PMC Article
Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E
Am J Obstet Gynecol 2017 Feb;216(2):110-120.e6. Epub 2016 Sep 15 doi: 10.1016/j.ajog.2016.09.076. PMID: 27640943
Brenner T, Schmitt FC, Demirel S, Salgado E, Celi de la Torre JA, Göring M, Bruckner T, Böckler D, Weigand MA, Hofer S, Attigah N
Vascular 2017 Feb;25(1):19-27. Epub 2016 Jul 9 doi: 10.1177/1708538116638961. PMID: 26993144

Recent systematic reviews

Phan K, Moore JM, Griessenauer CJ, Ogilvy CS, Thomas AJ
Stroke 2017 May;48(5):1210-1217. Epub 2017 Mar 24 doi: 10.1161/STROKEAHA.116.015674. PMID: 28341753
Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E
Am J Obstet Gynecol 2017 Feb;216(2):110-120.e6. Epub 2016 Sep 15 doi: 10.1016/j.ajog.2016.09.076. PMID: 27640943
Gargiulo G, Windecker S, Vranckx P, Gibson CM, Mehran R, Valgimigli M
Circulation 2016 Dec 6;134(23):1881-1906. doi: 10.1161/CIRCULATIONAHA.116.023952. PMID: 27920074
Elwood PC, Morgan G, Galante J, Chia JW, Dolwani S, Graziano JM, Kelson M, Lanas A, Longley M, Phillips CJ, Pickering J, Roberts SE, Soon SS, Steward W, Morris D, Weightman AL
PLoS One 2016;11(11):e0166166. Epub 2016 Nov 15 doi: 10.1371/journal.pone.0166166. PMID: 27846246Free PMC Article
Kokoska LA, Wilhelm SM, Garwood CL, Berlie HD
Diabetes Res Clin Pract 2016 Oct;120:31-9. Epub 2016 Jul 28 doi: 10.1016/j.diabres.2016.07.012. PMID: 27500549

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