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Items: 1 to 20 of 27

1.

Colitis

Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases. [from HPO]

MedGen UID:
40385
Concept ID:
C0009319
Disease or Syndrome
2.

Alpha 4 integrin antagonist

MedGen UID:
734350
Concept ID:
C1531499
Immunologic Factor; Pharmacologic Substance
3.

Inflammation

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
4.

46,XY sex reversal, type 2

Swyer syndrome is a condition that affects sexual development. Sexual development is usually determined by an individual's chromosomes; however, in Swyer syndrome, sexual development does not match the affected individual's chromosomal makeup.People usually have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Girls and women typically have two X chromosomes (46,XX karyotype), while boys and men usually have one X chromosome and one Y chromosome (46,XY karyotype). In Swyer syndrome, individuals with one X chromosome and one Y chromosome in each cell, the pattern typically found in boys and men, have female reproductive structures.People with Swyer syndrome have typical female external genitalia. The uterus and fallopian tubes are normally-formed, but the gonads (ovaries or testes) are not functional; affected individuals have undeveloped clumps of tissue called streak gonads. Because of the lack of development of the gonads, Swyer syndrome is also called 46,XY complete gonadal dysgenesis. The residual gonadal tissue often becomes cancerous, so it is usually removed surgically early in life.People with Swyer syndrome are typically raised as girls and have a female gender identity. Because they do not have functional ovaries, affected individuals usually begin hormone replacement therapy during adolescence to induce menstruation and development of female secondary sex characteristics such as breast enlargement and uterine growth. Hormone replacement therapy also helps reduce the risk of reduced bone density (osteopenia and osteoporosis). Women with this disorder do not produce eggs (ova), but they may be able to become pregnant with a donated egg or embryo.Swyer syndrome usually affects only sexual development; such cases are called isolated Swyer syndrome. However, depending on the genetic cause, Swyer syndrome may also occur along with health conditions such as nerve problems (neuropathy) or as part of a syndrome such as campomelic dysplasia, which causes severe skeletal abnormalities. [from GTR]

MedGen UID:
341190
Concept ID:
C1848296
Disease or Syndrome
5.

Recruitment

MedGen UID:
78772
Concept ID:
C0271510
Disease or Syndrome
6.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
7.

Dejerine-Sottas disease

Dejerine-Sottas neuropathy is a demyelinating peripheral neuropathy with onset in infancy. It can show autosomal dominant or recessive inheritance. Affected individuals have delayed motor development due to severe distal motor and sensory impairment, resulting in difficulties in gait. Some patients have generalized hypotonia in infancy. Other features may include pes cavus, scoliosis, and sensory ataxia. Nerve conduction velocities are severely decreased (sometimes less than 10 m/s), and sural nerve biopsy shows severe loss of myelinated fibers (summary by Baets et al., 2011). [from GTR]

MedGen UID:
3710
Concept ID:
C0011195
Disease or Syndrome
8.

Hemodex

MedGen UID:
214644
Concept ID:
C0918032
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
9.

Polyglucin

MedGen UID:
181524
Concept ID:
C0918033
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
10.

Rheopolyglucin

MedGen UID:
48446
Concept ID:
C0035425
Organic Chemical; Pharmacologic Substance
11.

Polysaccharide

A large carbohydrate molecule. It contains many small sugar molecules that are joined chemically. [from NCI_NCI-GLOSS]

MedGen UID:
46014
Concept ID:
C0032594
Organic Chemical; Pharmacologic Substance
12.

Glucans

Polysaccharides composed of repeating glucose units. They can consist of branched or unbranched chains in any linkages. [from MeSH]

MedGen UID:
42236
Concept ID:
C0017696
Organic Chemical; Pharmacologic Substance
13.

Dextrans

A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes. [from MeSH]

MedGen UID:
41516
Concept ID:
C0011806
Organic Chemical; Pharmacologic Substance
14.

Dextran

group of glucose polymers made by certain bacteria; dextrans are used therapeutically as plasma volume expanders and anticoagulants; they are also commonly used in biological experimentation and in industry for a wide variety of purposes. [from CRISP]

MedGen UID:
39398
Concept ID:
C0086140
Organic Chemical; Pharmacologic Substance
15.

Dextran Sulfate

Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications. [from MeSH]

MedGen UID:
38188
Concept ID:
C0079224
Organic Chemical; Pharmacologic Substance
16.

Saviosol

MedGen UID:
20656
Concept ID:
C0036246
Organic Chemical; Pharmacologic Substance
17.

Rheodextran

MedGen UID:
20564
Concept ID:
C0035420
Organic Chemical; Pharmacologic Substance
18.

Rheomacrodex

MedGen UID:
19778
Concept ID:
C0035424
Organic Chemical; Pharmacologic Substance
19.

Rheoisodex

MedGen UID:
19777
Concept ID:
C0035422
Organic Chemical; Pharmacologic Substance
20.

Promit

MedGen UID:
10938
Concept ID:
C0033409
Organic Chemical; Pharmacologic Substance
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