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Ganglioside

MedGen UID:
4832
Concept ID:
C0017082
Lipid; Organic Chemical; Pharmacologic Substance
Synonyms: Gangliosides; Sialoglycosphingolipids
SNOMED CT: Ganglioside (31310007)
 

Definition

A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGanglioside

Recent clinical studies

Etiology

Jeon Y, Kim B, Kim JE, Kim BR, Ban S, Jeong JH, Kwon O, Rhie SJ, Ahn CW, Kim JH, Jung SU, Park SH, Lyoo IK, Yoon S
Am J Chin Med 2016;44(3):489-514. Epub 2016 Apr 24 doi: 10.1142/S0192415X16500270. PMID: 27109158
Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT
World J Gastroenterol 2015 Sep 21;21(35):10080-90. doi: 10.3748/wjg.v21.i35.10080. PMID: 26401073Free PMC Article
Saariaho AH, Vuorela A, Freitag TL, Pizza F, Plazzi G, Partinen M, Vaarala O, Meri S
J Autoimmun 2015 Sep;63:68-75. Epub 2015 Jul 27 doi: 10.1016/j.jaut.2015.07.006. PMID: 26227560
Torbidoni AV, Scursoni A, Camarero S, Segatori V, Gabri M, Alonso D, Chantada G, de Dávila MT
Acta Ophthalmol 2015 Jun;93(4):e294-300. Epub 2014 Nov 17 doi: 10.1111/aos.12578. PMID: 25403557
Wu X, Wu W, Wang Z, Shen D, Pan W, Wang Y, Wu L, Wu X, Feng J, Liu K, Zhu J, Zhang HL
PLoS One 2014;9(8):e104074. Epub 2014 Aug 1 doi: 10.1371/journal.pone.0104074. PMID: 25084153Free PMC Article

Diagnosis

Koga M, Takahashi M, Yokoyama K, Kanda T
J Neurol 2015 Aug;262(8):1954-60. Epub 2015 Jun 9 doi: 10.1007/s00415-015-7806-4. PMID: 26050638
Liu L, Zhang K, Tan L, Chen YH, Cao YP
Alzheimer Dis Assoc Disord 2015 Jan-Mar;29(1):63-9. doi: 10.1097/WAD.0000000000000041. PMID: 24759545
Tringali C, Silvestri I, Testa F, Baldassari P, Anastasia L, Mortarini R, Anichini A, López-Requena A, Tettamanti G, Venerando B
BMC Cancer 2014 Aug 1;14:560. doi: 10.1186/1471-2407-14-560. PMID: 25085576Free PMC Article
Harlalka GV, Lehman A, Chioza B, Baple EL, Maroofian R, Cross H, Sreekantan-Nair A, Priestman DA, Al-Turki S, McEntagart ME, Proukakis C, Royle L, Kozak RP, Bastaki L, Patton M, Wagner K, Coblentz R, Price J, Mezei M, Schlade-Bartusiak K, Platt FM, Hurles ME, Crosby AH
Brain 2013 Dec;136(Pt 12):3618-24. Epub 2013 Oct 7 doi: 10.1093/brain/awt270. PMID: 24103911Free PMC Article
Tian R, Jin J, Taylor L, Larsen B, Quaggin SE, Pawson T
Proteomics 2013 Apr;13(8):1334-8. Epub 2013 Mar 12 doi: 10.1002/pmic.201200410. PMID: 23401482

Therapy

Jeon Y, Kim B, Kim JE, Kim BR, Ban S, Jeong JH, Kwon O, Rhie SJ, Ahn CW, Kim JH, Jung SU, Park SH, Lyoo IK, Yoon S
Am J Chin Med 2016;44(3):489-514. Epub 2016 Apr 24 doi: 10.1142/S0192415X16500270. PMID: 27109158
Saariaho AH, Vuorela A, Freitag TL, Pizza F, Plazzi G, Partinen M, Vaarala O, Meri S
J Autoimmun 2015 Sep;63:68-75. Epub 2015 Jul 27 doi: 10.1016/j.jaut.2015.07.006. PMID: 26227560
He L, Zhang G, Liu W, Gao T, Sheikh KA
J Neurosci 2015 Apr 29;35(17):6770-85. doi: 10.1523/JNEUROSCI.4926-14.2015. PMID: 25926454Free PMC Article
Wu X, Wu W, Wang Z, Shen D, Pan W, Wang Y, Wu L, Wu X, Feng J, Liu K, Zhu J, Zhang HL
PLoS One 2014;9(8):e104074. Epub 2014 Aug 1 doi: 10.1371/journal.pone.0104074. PMID: 25084153Free PMC Article
Doronin II, Vishnyakova PA, Kholodenko IV, Ponomarev ED, Ryazantsev DY, Molotkovskaya IM, Kholodenko RV
BMC Cancer 2014 Apr 28;14:295. doi: 10.1186/1471-2407-14-295. PMID: 24773917Free PMC Article

Prognosis

Tringali C, Silvestri I, Testa F, Baldassari P, Anastasia L, Mortarini R, Anichini A, López-Requena A, Tettamanti G, Venerando B
BMC Cancer 2014 Aug 1;14:560. doi: 10.1186/1471-2407-14-560. PMID: 25085576Free PMC Article
Wu X, Wu W, Wang Z, Shen D, Pan W, Wang Y, Wu L, Wu X, Feng J, Liu K, Zhu J, Zhang HL
PLoS One 2014;9(8):e104074. Epub 2014 Aug 1 doi: 10.1371/journal.pone.0104074. PMID: 25084153Free PMC Article
Harlalka GV, Lehman A, Chioza B, Baple EL, Maroofian R, Cross H, Sreekantan-Nair A, Priestman DA, Al-Turki S, McEntagart ME, Proukakis C, Royle L, Kozak RP, Bastaki L, Patton M, Wagner K, Coblentz R, Price J, Mezei M, Schlade-Bartusiak K, Platt FM, Hurles ME, Crosby AH
Brain 2013 Dec;136(Pt 12):3618-24. Epub 2013 Oct 7 doi: 10.1093/brain/awt270. PMID: 24103911Free PMC Article
Sinici I, Yonekawa S, Tkachyova I, Gray SJ, Samulski RJ, Wakarchuk W, Mark BL, Mahuran DJ
PLoS One 2013;8(3):e57908. Epub 2013 Mar 4 doi: 10.1371/journal.pone.0057908. PMID: 23483939Free PMC Article
Zhong Y, Wu Y, Li C, Tang J, Wang X, Ren G, Carr A, Pérez R, Guo W
Oral Dis 2012 Nov;18(8):741-7. Epub 2012 May 10 doi: 10.1111/j.1601-0825.2012.01939.x. PMID: 22574836

Clinical prediction guides

Jeon Y, Kim B, Kim JE, Kim BR, Ban S, Jeong JH, Kwon O, Rhie SJ, Ahn CW, Kim JH, Jung SU, Park SH, Lyoo IK, Yoon S
Am J Chin Med 2016;44(3):489-514. Epub 2016 Apr 24 doi: 10.1142/S0192415X16500270. PMID: 27109158
Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT
World J Gastroenterol 2015 Sep 21;21(35):10080-90. doi: 10.3748/wjg.v21.i35.10080. PMID: 26401073Free PMC Article
Torbidoni AV, Scursoni A, Camarero S, Segatori V, Gabri M, Alonso D, Chantada G, de Dávila MT
Acta Ophthalmol 2015 Jun;93(4):e294-300. Epub 2014 Nov 17 doi: 10.1111/aos.12578. PMID: 25403557
Kaneko T, Tsubakihara Y, Fushimi H, Yamaguchi S, Takabatake Y, Rakugi H, Kawakami H, Isaka Y
Clin Exp Nephrol 2015 Jun;19(3):403-10. Epub 2014 Jul 2 doi: 10.1007/s10157-014-1003-0. PMID: 24985965
Wu X, Wu W, Wang Z, Shen D, Pan W, Wang Y, Wu L, Wu X, Feng J, Liu K, Zhu J, Zhang HL
PLoS One 2014;9(8):e104074. Epub 2014 Aug 1 doi: 10.1371/journal.pone.0104074. PMID: 25084153Free PMC Article

Recent systematic reviews

Gabri MR, Cacciavillano W, Chantada GL, Alonso DF
Expert Opin Biol Ther 2016;16(4):573-8. doi: 10.1517/14712598.2016.1157579. PMID: 26903265
Ryan JM, Rice GE, Mitchell MD
Nutr Res 2013 Nov;33(11):877-87. Epub 2013 Sep 5 doi: 10.1016/j.nutres.2013.07.021. PMID: 24176227
Rinaldi S, Willison HJ
Curr Opin Neurol 2008 Oct;21(5):540-6. doi: 10.1097/WCO.0b013e32830b84b7. PMID: 18769247
Chinnock P, Roberts I
Cochrane Database Syst Rev 2005 Apr 18;(2):CD004444. doi: 10.1002/14651858.CD004444.pub2. PMID: 15846715
Hadjiconstantinou M, Neff NH
J Neurochem 1998 Apr;70(4):1335-45. PMID: 9523549

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