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Primary hyperaldosteronism

MedGen UID:
278002
Concept ID:
C1384514
Disease or Syndrome
Synonyms: Conn's syndrome
SNOMED CT: Idiopathic hyperaldosteronism (258117004); Primary hyperaldosteronism (190507007); Conn's syndrome (190507007); Conn syndrome (190507007); Primary aldosteronism (190507007); Idiopathic aldosteronism (258117004)
 
HPO: HP:0011736

Definition

A form of hyperaldosteronism caused by a defect within the adrenal gland. [from HPO]

Recent clinical studies

Etiology

Kuo LE, Wachtel H, Roses RE, Fraker DL, Kelz RR
Ann Surg Oncol 2015 Dec;22 Suppl 3:S734-41. Epub 2015 Jul 21 doi: 10.1245/s10434-015-4729-3. PMID: 26193964
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. PMID: 25456918
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682
Douma S, Petidis K, Doumas M, Papaefthimiou P, Triantafyllou A, Kartali N, Papadopoulos N, Vogiatzis K, Zamboulis C
Lancet 2008 Jun 7;371(9628):1921-6. doi: 10.1016/S0140-6736(08)60834-X. PMID: 18539224

Diagnosis

Carroll R, Gould A, Feltham J, Harper S
N Z Med J 2017 May 12;130(1455):129-132. PMID: 28494487
Kuo LE, Wachtel H, Roses RE, Fraker DL, Kelz RR
Ann Surg Oncol 2015 Dec;22 Suppl 3:S734-41. Epub 2015 Jul 21 doi: 10.1245/s10434-015-4729-3. PMID: 26193964
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682
Douma S, Petidis K, Doumas M, Papaefthimiou P, Triantafyllou A, Kartali N, Papadopoulos N, Vogiatzis K, Zamboulis C
Lancet 2008 Jun 7;371(9628):1921-6. doi: 10.1016/S0140-6736(08)60834-X. PMID: 18539224

Therapy

Kuo LE, Wachtel H, Roses RE, Fraker DL, Kelz RR
Ann Surg Oncol 2015 Dec;22 Suppl 3:S734-41. Epub 2015 Jul 21 doi: 10.1245/s10434-015-4729-3. PMID: 26193964
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682
Martínez JJ, Oliveira CL, Meneses AL, Rodríguez SA, Corrales PP, López AH, Romero FB
Endocrinol Nutr 2009 Oct;56(8):431-4. doi: 10.1016/S1575-0922(09)72715-9. PMID: 19959155
Douma S, Petidis K, Doumas M, Papaefthimiou P, Triantafyllou A, Kartali N, Papadopoulos N, Vogiatzis K, Zamboulis C
Lancet 2008 Jun 7;371(9628):1921-6. doi: 10.1016/S0140-6736(08)60834-X. PMID: 18539224

Prognosis

Moradi S, Shafiepour M, Amirbaigloo A
Acta Med Iran 2016 Feb;54(2):156-8. PMID: 26997605
Pedersen M, Karlsen MA, Ankjærgaard KL, Jensen LT
Scand J Clin Lab Invest 2016;76(1):45-50. Epub 2015 Oct 15 doi: 10.3109/00365513.2015.1092047. PMID: 26471096
Kuo LE, Wachtel H, Roses RE, Fraker DL, Kelz RR
Ann Surg Oncol 2015 Dec;22 Suppl 3:S734-41. Epub 2015 Jul 21 doi: 10.1245/s10434-015-4729-3. PMID: 26193964
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. PMID: 25456918
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. PMID: 23090573Free PMC Article

Clinical prediction guides

Raman SP, Lessne M, Kawamoto S, Chen Y, Salvatori R, Prescott JD, Fishman EK
J Comput Assist Tomogr 2015 May-Jun;39(3):414-8. doi: 10.1097/RCT.0000000000000208. PMID: 25594382
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. PMID: 25456918
Layden BT, Hahr AJ, Elaraj DM
BMC Res Notes 2012 Oct 30;5:602. doi: 10.1186/1756-0500-5-602. PMID: 23110780Free PMC Article
Douma S, Petidis K, Doumas M, Papaefthimiou P, Triantafyllou A, Kartali N, Papadopoulos N, Vogiatzis K, Zamboulis C
Lancet 2008 Jun 7;371(9628):1921-6. doi: 10.1016/S0140-6736(08)60834-X. PMID: 18539224
Pizzolo F, Pavan C, Guarini P, Trabetti E, Girelli D, Corrocher R, Olivieri O
J Hypertens 2005 Nov;23(11):2041-7. PMID: 16208147

Recent systematic reviews

Leung AA, Nerenberg K, Daskalopoulou SS, McBrien K, Zarnke KB, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tobe SW, Ruzicka M, Burns KD, Vallée M, Prasad GV, Lebel M, Feldman RD, Selby P, Pipe A, Schiffrin EL, McFarlane PA, Oh P, Hegele RA, Khara M, Wilson TW, Penner SB, Burgess E, Herman RJ, Bacon SL, Rabkin SW, Gilbert RE, Campbell TS, Grover S, Honos G, Lindsay P, Hill MD, Coutts SB, Gubitz G, Campbell NR, Moe GW, Howlett JG, Boulanger JM, Prebtani A, Larochelle P, Leiter LA, Jones C, Ogilvie RI, Woo V, Kaczorowski J, Trudeau L, Petrella RJ, Hiremath S, Drouin D, Lavoie KL, Hamet P, Fodor G, Grégoire JC, Lewanczuk R, Dresser GK, Sharma M, Reid D, Lear SA, Moullec G, Gupta M, Magee LA, Logan AG, Harris KC, Dionne J, Fournier A, Benoit G, Feber J, Poirier L, Padwal RS, Rabi DM; CHEP Guidelines Task Force.
Can J Cardiol 2016 May;32(5):569-88. Epub 2016 Mar 10 doi: 10.1016/j.cjca.2016.02.066. PMID: 27118291
Bednarczuk T, Bolanowski M, Sworczak K, Górnicka B, Cieszanowski A, Otto M, Ambroziak U, Pachucki J, Kubicka E, Babińska A, Koperski Ł, Januszewicz A, Prejbisz A, Górska M, Jarząb B, Hubalewska-Dydejczyk A, Glinicki P, Ruchała M, Kasperlik-Załuska A
Endokrynol Pol 2016;67(2):234-58. doi: 10.5603/EP.a2016.0039. PMID: 27082051
Garcia EA, Lopez JR, Meier JL, Swislocki AL, Siegel D
J Clin Hypertens (Greenwich) 2011 Jul;13(7):487-91. Epub 2011 Mar 28 doi: 10.1111/j.1751-7176.2011.00443.x. PMID: 21762361
Martínez JJ, Oliveira CL, Meneses AL, Rodríguez SA, Corrales PP, López AH, Romero FB
Endocrinol Nutr 2009 Oct;56(8):431-4. doi: 10.1016/S1575-0922(09)72715-9. PMID: 19959155
Nwariaku FE, Miller BS, Auchus R, Holt S, Watumull L, Dolmatch B, Nesbitt S, Vongpatanasin W, Victor R, Wians F, Livingston E, Snyder WH 3rd
Arch Surg 2006 May;141(5):497-502; discussion 502-3. doi: 10.1001/archsurg.141.5.497. PMID: 16702522

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