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Items: 6

1.

Primary insomnia

A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition. [from NCI]

MedGen UID:
18633
Concept ID:
C0033139
Disease or Syndrome
2.

Insomnia

MedGen UID:
409589
Concept ID:
C1963237
Finding
3.

Insomnia

A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep. [from NCI]

MedGen UID:
214589
Concept ID:
C0917801
Sign or Symptom
4.

Humulus lupulus extract

MedGen UID:
167882
Concept ID:
C0872896
Organic Chemical; Pharmacologic Substance
5.

Valerian root extract

An herbal extract isolated from the root of the plant Valeriana officinalis with sedative and anxiolytic activities. Valeriana officinalis extract contains four distinct classes of phytochemical constituents: volatile oils; sesquiterpenoids, including valerenic acid and its hydroxyl and acetoxyl derivative; valepotriates; and volatile pyridine alkaloids. Although the exact mechanism of action has not been established, the sesquiterpenoids in Valeriana officinalis extract, particularly valerenic acid, appear to account for its sedative and anxiolytic effects. Valerenic acid is both a subtype-selective GABA-A receptor agonist and a 5HT-5A receptor partial agonist. The sedative-hypnotic benzodiazepines are GABA-A receptor agonists. [from NCI]

MedGen UID:
167051
Concept ID:
C0795674
Organic Chemical; Pharmacologic Substance
6.

Infantile hypophosphatasia

Hypophosphatasia is characterized by defective mineralization of bone and/or teeth in the presence of low activity of serum and bone alkaline phosphatase. Clinical features range from stillbirth without mineralized bone at the severe end to pathologic fractures of the lower extremities in later adulthood at the mild end. Although the disease spectrum is a continuum, six clinical forms are usually recognized based on age at diagnosis and severity of features: Perinatal (severe) hypophosphatasia characterized by respiratory insufficiency and hypercalcemia. Perinatal (benign) hypophosphatasia with prenatal skeletal manifestations that slowly resolve into one of the milder forms. Infantile hypophosphatasia with onset between birth and age six months of rickets without elevated serum alkaline phosphatase activity. Childhood (juvenile) hypophosphatasia that ranges from low bone mineral density for age with unexplained fractures to rickets, and premature loss of primary teeth with intact roots. Adult hypophosphatasia characterized by stress fractures and pseudofractures of the lower extremities in middle age, sometimes associated with early loss of adult dentition. Odontohypophosphatasia characterized by premature exfoliation of primary teeth and/or severe dental caries without skeletal manifestations. [from GTR]

MedGen UID:
75677
Concept ID:
C0268412
Disease or Syndrome
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