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Items: 1 to 20 of 73

1.

Chromosomal Instability

The instability of chromosomes is attributed to the continuous formation of novel chromosome mutations. These mutations form at an elevated rate in comparison to the normal cell population. The increased frequency of structural chromosome aberrations can be caused by an abnormally high incidence of DNA double-strand breaks and translocations. Screening for chromosomal breakage and rearrangement is used as a diagnostic tool in Fanconi anemia. [from NCI]

MedGen UID:
263436
Concept ID:
C1257806
Cell or Molecular Dysfunction
2.

Gastritis

Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders. [from MeSH]

MedGen UID:
4843
Concept ID:
C0017152
Disease or Syndrome
3.

Gastritis cystica profunda

MedGen UID:
871619
Concept ID:
C4038754
Disease or Syndrome
4.

Instability

MedGen UID:
731956
Concept ID:
C1444783
Finding
5.

Multifocal

Arising from, pertaining to, or having many locations. [from NCI]

MedGen UID:
59976
Concept ID:
C0205292
Spatial Concept
6.

Heterotopia

A mass of histologically normal tissue present in an abnormal location. [from MeSH]

MedGen UID:
40280
Concept ID:
C0008519
Pathologic Function
7.

Adenocarcinoma

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
8.

Weight loss

A reduction in total body weight. [from NCI]

MedGen UID:
853198
Concept ID:
C1262477
Finding; Finding
9.

Genomic Instability

A biological process consisting of chromosomal rearrangements and duplications. These phenotypes are often seen in the karyotype of cancer cells, where there is an imbalance between the mechanisms of cell-cycle control and mutation rates within aberrant genes. Ataxia telangiectasia is a disease that is resultant from mutations in the ATM gene, which is a cell cycle checkpoint gene. Nijmegen breakage syndrome is also a disease characterized by chromosomal and genomic instability. [from NCI]

MedGen UID:
182518
Concept ID:
C0919532
Cell or Molecular Dysfunction
10.

Pain

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. [from MeSH]

MedGen UID:
45282
Concept ID:
C0030193
Sign or Symptom
11.

Cyst

A sac-like closed membranous structure that may be empty or contain fluid or amorphous material. [from NCI]

MedGen UID:
41396
Concept ID:
C0010709
Disease or Syndrome
12.

Abdominal pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen. [from HPO]

MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
13.

Pain

MedGen UID:
880950
Concept ID:
CN236637
Disease or Syndrome
14.

Adenocarcinoma of the small intestine

A malignant epithelial tumor with a glandular organization that originates in the small intestine. [from HPO]

MedGen UID:
82984
Concept ID:
C0278803
Neoplastic Process
15.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
16.

Disorder of glucose metabolism

A metabolic disorder characterized by abnormal blood glucose levels. [from NCI]

MedGen UID:
226229
Concept ID:
C1257958
Disease or Syndrome
17.

Pathological Conditions, Anatomical

An abnormal structural condition of the human body, usually macroscopic, that is common to a variety of different diseases. [from MeSH]

MedGen UID:
155708
Concept ID:
C0752135
Pathologic Function
18.

Carcinomatosis

Carcinoma that has spread diffusely to an anatomic site or throughout the body. [from NCI]

MedGen UID:
104704
Concept ID:
C0205699
Neoplastic Process
19.

Cribriform Carcinoma

A carcinoma characterized by the presence of a cribriform architectural pattern. Representative examples include the intraductal cribriform breast carcinoma and invasive cribriform breast carcinoma. [from NCI]

MedGen UID:
104694
Concept ID:
C0205643
Neoplastic Process
20.

Tubular Adenocarcinoma

An infiltrating adenocarcinoma in which the malignant cells form tubular structures. Representative examples include the tubular breast carcinoma and the gastric tubular adenocarcinoma. [from NCI]

MedGen UID:
61428
Concept ID:
C0205645
Neoplastic Process
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