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Items: 18

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

Triggered by

A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation. [from HPO]

MedGen UID:
252950
Concept ID:
C1444748
Qualitative Concept
3.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
4.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
5.

Intropin

MedGen UID:
147406
Concept ID:
C0721081
Organic Chemical; Pharmacologic Substance
6.

Excitatory Amino Acid Agents

Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids. [from MeSH]

MedGen UID:
116696
Concept ID:
C0242900
Pharmacologic Substance
7.

Dopamine antagonist

Any agent that binds to and blocks dopamine receptors. [from NCI]

MedGen UID:
116643
Concept ID:
C0242702
Pharmacologic Substance
8.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
9.

Glutamate receptor antagonist

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. [from MeSH]

MedGen UID:
66180
Concept ID:
C0242910
Pharmacologic Substance
10.

D-Glutamate

MedGen UID:
49306
Concept ID:
C0112117
Amino Acid, Peptide, or Protein; Pharmacologic Substance
11.

Glutamic acid

A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. [from MeSH]

MedGen UID:
29630
Concept ID:
C0061472
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
12.

Agents, Dopaminergic

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. [from MeSH]

MedGen UID:
4380
Concept ID:
C0013036
Pharmacologic Substance
13.

Biogenic amine

A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology. [from MeSH]

MedGen UID:
2255
Concept ID:
C0005496
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
14.

Catecholamine

A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine. [from MeSH]

MedGen UID:
805
Concept ID:
C0007412
Biologically Active Substance; Pharmacologic Substance
15.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
16.

6,7-dinitroquinoxaline-2,3-dione

MedGen UID:
48000
Concept ID:
C0114721
Organic Chemical; Pharmacologic Substance
17.

FG 9041

MedGen UID:
28997
Concept ID:
C0060311
Organic Chemical; Pharmacologic Substance
18.

Deficiency of amine oxidase

MedGen UID:
698740
Concept ID:
C1275476
Disease or Syndrome
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