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Items: 1 to 20 of 39

1.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
2.

Human insulin product

Regular insulin preparations that contain the HUMAN insulin peptide sequence. [from MeSH]

MedGen UID:
162753
Concept ID:
C0795635
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
3.

Insulin-like growth factor binding protein 3

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level. [from MeSH]

MedGen UID:
50114
Concept ID:
C0123707
Amino Acid, Peptide, or Protein; Pharmacologic Substance
4.

Regular insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). [from MeSH]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
5.

Transforming growth factor beta 1

A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME. [from MeSH]

MedGen UID:
316445
Concept ID:
C1704256
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
6.

Growth Factor Binding

Growth Factor Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and often spatial complementarity with extracellular signaling molecules (ligands) involved in the control of target cell proliferation, survival, and differentiation. [from NCI]

MedGen UID:
218860
Concept ID:
C1149299
Molecular Function
7.

Esophageal Squamous Cell Carcinoma

A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor. [from NCI]

MedGen UID:
124635
Concept ID:
C0279626
Neoplastic Process
8.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
9.

Carcinoma

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed) [from MeSH]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
10.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
11.

Transplantation

MedGen UID:
881115
Concept ID:
CN236682
Disease or Syndrome
12.

Squamous cell carcinoma of esophagus

Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC; see this term) that can affect any part of the esophagus, but is usually located in the upper or middle third. [from ORDO]

MedGen UID:
832478
Concept ID:
CN207490
Disease or Syndrome
13.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
14.

Squamous cell carcinoma

The presence of squamous cell carcinoma of the skin. [from HPO]

MedGen UID:
505376
Concept ID:
CN002585
Finding
15.

EGFR-related lung cancer

MedGen UID:
472093
Concept ID:
CN130014
Disease or Syndrome
16.

Esophageal neoplasm

A tumor (abnormal growth of tissue) of the esophagus. [from HPO]

MedGen UID:
451997
Concept ID:
CN117641
Finding
17.

Invasion

The movement of one cell type into an area normally occupied by a different cell type. [from NCI]

MedGen UID:
397081
Concept ID:
C2699153
Pathologic Function
18.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
19.

Frequent

Coming at short intervals or in great quantities. [from NCI]

MedGen UID:
87144
Concept ID:
C0332183
Temporal Concept
20.

Esophageal Neoplasms

A benign or malignant neoplasm involving the esophagus. [from NCI]

MedGen UID:
4547
Concept ID:
C0014859
Neoplastic Process
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