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Items: 5

1.

Fluctuation

MedGen UID:
533667
Concept ID:
C0231239
Sign or Symptom
2.

Weight fluctuates

MedGen UID:
66035
Concept ID:
C0241729
Finding
3.

Multiple endocrine neoplasia

An autosomal dominant inherited neoplastic syndrome characterized by the development of various endocrine neoplasms and abnormalities in various anatomic sites. There are three types recognized: type 1 (MEN 1), caused by inactivation of the tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET gene, and type 2B (MEN 2B) also caused by mutation of the RET gene. Patients with MEN 1 may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid carcinomas, and may also develop pheochromocytomas and parathyroid gland hyperplasia. Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural defects including neuromas. [from NCI]

MedGen UID:
45036
Concept ID:
C0027662
Neoplastic Process
4.

Weight change

A clinical manifestation consisting of alterations in an individual's weight from his or her norm. [from MeSH]

MedGen UID:
2305
Concept ID:
C0005911
Finding
5.

Stopped smoking

MedGen UID:
603919
Concept ID:
C0425310
Finding
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