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Items: 16

1.

breast cancer

MedGen UID:
880206
Concept ID:
CN235590
Finding
2.

Breast cancer

MedGen UID:
808165
Concept ID:
CN221572
Disease or Syndrome
3.

Neoplasm of the breast

A tumor (abnormal growth of tissue) of the breast. [from HPO]

MedGen UID:
506444
Concept ID:
CN116912
Finding
4.

Breast carcinoma

The presence of a carcinoma of the breast. [from HPO]

MedGen UID:
428324
Concept ID:
CN002714
Finding
5.

Diarrhea

MedGen UID:
368098
Concept ID:
C1963091
Finding
6.

Neoplasm of breast

Tumors or cancer of the human BREAST. [from MeSH]

MedGen UID:
264172
Concept ID:
C1458155
Neoplastic Process
7.

Congestive heart failure

Heart failure accompanied by EDEMA, such as swelling of the legs and ankles and congestion in the lungs. [from MeSH]

MedGen UID:
9169
Concept ID:
C0018802
Disease or Syndrome
8.

Heart failure

Heart failure is a condition in which the heart can't pump enough blood to meet the body's needs. Heart failure does not mean that your heart has stopped or is about to stop working. It means that your heart is not able to pump blood the way it should. It can affect one or both sides of the heart. The weakening of the heart's pumping ability causes. -Blood and fluid to back up into the lungs. -The buildup of fluid in the feet, ankles and legs - called edema. -Tiredness and shortness of breath. Common causes of heart failure are coronary artery disease, high blood pressure and diabetes. It is more common in people who are 65 years old or older, African Americans, people who are overweight, and people who have had a heart attack. Men have a higher rate of heart failure than women. Your doctor will diagnose heart failure by doing a physical exam and heart tests. Treatment includes treating the underlying cause of your heart failure, medicines, and heart transplantation if other treatments fail. NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
9.

Heart Failure

MedGen UID:
880986
Concept ID:
CN236639
Disease or Syndrome
10.

Delay

MedGen UID:
879911
Concept ID:
CN235300
Finding
11.

Congestive heart failure

The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction. [from HPO]

MedGen UID:
504881
Concept ID:
CN001488
Finding
12.

Asymptomatic

The finding of no indications of a particular disease or injury. [from NCI]

MedGen UID:
65413
Concept ID:
C0231221
Finding
13.

Disorder of skin

Your skin is your body's largest organ. It covers and protects your body. Your skin. -Holds body fluids in, preventing dehydration. -Keeps harmful microbes out, preventing infections. -Helps you feel things like heat, cold, and pain. -Keeps your body temperature even. -Makes vitamin D when the sun shines on it. Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases.  [from MedlinePlus]

MedGen UID:
20777
Concept ID:
C0037274
Disease or Syndrome
14.

Signs and Symptoms, Digestive

Digestive system manifestations of diseases of the gastrointestinal system or of other organs. [from MeSH]

MedGen UID:
19975
Concept ID:
C0037089
Sign or Symptom
15.

Trastuzumab response

The HER2 gene is overexpressed in 15-20% of breast cancers and is also overexpressed in some cases of gastric cancer. Overall, "HER2 positive" tumors are associated with a faster rate of growth and a poorer prognosis. The use of trastuzumab in treatment regimes improves outcomes, but adverse effects of therapy include cardiac toxicity. The FDA-approved drug label for trastuzumab states that trastuzumab should only be used to treat patients with tumors that have either HER2 protein overexpression or HER2 gene amplification, as determined by an accurate and validated FDA-approved assay, specific for the type of tumor tested (breast or gastric). This is because these are the only patients studied for whom benefit has been shown. A guideline from ASCO/CAP states that oncologists must request HER2 testing on every primary invasive breast cancer (and on a metastatic site, if stage IV and if specimen available) from a patient with breast cancer to guide decision to pursue HER2-targeted therapy. This should be especially considered for a patient who previously tested HER2 negative in a primary tumor and presents with disease recurrence with clinical behavior suggestive of HER2-positive or triple-negative disease. [from Medical Genetics Summaries]

MedGen UID:
450497
Concept ID:
CN078025
Sign or Symptom
16.

Lapatinib response

MedGen UID:
450464
Concept ID:
CN077992
Sign or Symptom
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