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Buprenorphine

MedGen UID:
14252
Concept ID:
C0006405
Organic Chemical; Pharmacologic Substance
Synonyms: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
SNOMED CT: Buprenorphine (387173000); Buprenorphine (31684002)
 

Definition

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBuprenorphine

Recent clinical studies

Etiology

Chavoustie S, Frost M, Snyder O, Owen J, Darwish M, Dammerman R, Sanjurjo V
Expert Rev Clin Pharmacol 2017 Aug;10(8):799-807. Epub 2017 Jun 21 doi: 10.1080/17512433.2017.1336434. PMID: 28571505
Richards S, Torre L, Lawther B
Anaesth Intensive Care 2017 Mar;45(2):256-261. PMID: 28267949
Albayaty M, Linden M, Olsson H, Johnsson M, Strandgården K, Tiberg F
Adv Ther 2017 Feb;34(2):560-575. Epub 2017 Jan 9 doi: 10.1007/s12325-016-0472-9. PMID: 28070862
Sullivan M, Bisaga A, Pavlicova M, Choi CJ, Mishlen K, Carpenter KM, Levin FR, Dakwar E, Mariani JJ, Nunes EV
Am J Psychiatry 2017 May 1;174(5):459-467. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050548. PMID: 28068780Free PMC Article
Sessler NE, Walker E, Chickballapur H, Kacholakalayil J, Coplan PM
Postgrad Med 2017 Jan;129(1):62-68. doi: 10.1080/00325481.2016.1271698. PMID: 27977317

Diagnosis

Sessler NE, Walker E, Chickballapur H, Kacholakalayil J, Coplan PM
Postgrad Med 2017 Jan;129(1):62-68. doi: 10.1080/00325481.2016.1271698. PMID: 27977317
Joshi A, Parris B, Liu Y, Heidbreder C, Gerk PM, Halquist M
Biomed Chromatogr 2017 Feb;31(2) Epub 2016 Aug 22 doi: 10.1002/bmc.3785. PMID: 27390058
Swortwood MJ, Scheidweiler KB, Barnes AJ, Jansson LM, Huestis MA
J Chromatogr A 2016 May 13;1446:70-7. Epub 2016 Mar 31 doi: 10.1016/j.chroma.2016.03.076. PMID: 27083254
Manhapra A, Quinones L, Rosenheck R
Drug Alcohol Depend 2016 Mar 1;160:82-9. Epub 2016 Jan 13 doi: 10.1016/j.drugalcdep.2015.12.035. PMID: 26804898Free PMC Article
Hirst A, Knight C, Hirst M, Dunlop W, Akehurst R
Eur J Health Econ 2016 Mar;17(2):217-27. Epub 2015 Apr 11 doi: 10.1007/s10198-015-0673-1. PMID: 25861916Free PMC Article

Therapy

Chavoustie S, Frost M, Snyder O, Owen J, Darwish M, Dammerman R, Sanjurjo V
Expert Rev Clin Pharmacol 2017 Aug;10(8):799-807. Epub 2017 Jun 21 doi: 10.1080/17512433.2017.1336434. PMID: 28571505
Richards S, Torre L, Lawther B
Anaesth Intensive Care 2017 Mar;45(2):256-261. PMID: 28267949
Jansson LM, Velez M, McConnell K, Spencer N, Tuten M, Jones HE, King VL, Gandotra N, Milio LA, Voegtline K, DiPietro JA
Am J Obstet Gynecol 2017 May;216(5):529.e1-529.e8. Epub 2017 Feb 7 doi: 10.1016/j.ajog.2017.01.040. PMID: 28188773Free PMC Article
Sullivan M, Bisaga A, Pavlicova M, Choi CJ, Mishlen K, Carpenter KM, Levin FR, Dakwar E, Mariani JJ, Nunes EV
Am J Psychiatry 2017 May 1;174(5):459-467. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050548. PMID: 28068780Free PMC Article
Maharao NV, Joshi AA, Gerk PM
Biopharm Drug Dispos 2017 Mar;38(2):139-154. Epub 2017 Jan 24 doi: 10.1002/bdd.2050. PMID: 27925249

Prognosis

Kelty E, Hulse G
Drugs 2017 Jul;77(11):1211-1219. doi: 10.1007/s40265-017-0763-8. PMID: 28536981
Maharao NV, Joshi AA, Gerk PM
Biopharm Drug Dispos 2017 Mar;38(2):139-154. Epub 2017 Jan 24 doi: 10.1002/bdd.2050. PMID: 27925249
Lo-Ciganic WH, Gellad WF, Gordon AJ, Cochran G, Zemaitis MA, Cathers T, Kelley D, Donohue JM
Addiction 2016 May;111(5):892-902. Epub 2016 Jan 30 doi: 10.1111/add.13270. PMID: 26662858
O'Connor AB, O'Brien L, Alto WA, Wong J
J Matern Fetal Neonatal Med 2016;29(1):112-4. Epub 2014 Dec 10 doi: 10.3109/14767058.2014.987750. PMID: 25394611
Larance B, Dietze P, Ali R, Lintzeris N, White N, Jenkinson R, Degenhardt L
Drug Alcohol Rev 2015 Nov;34(6):603-10. Epub 2015 May 6 doi: 10.1111/dar.12277. PMID: 25950232

Clinical prediction guides

Sullivan M, Bisaga A, Pavlicova M, Choi CJ, Mishlen K, Carpenter KM, Levin FR, Dakwar E, Mariani JJ, Nunes EV
Am J Psychiatry 2017 May 1;174(5):459-467. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050548. PMID: 28068780Free PMC Article
Sessler NE, Walker E, Chickballapur H, Kacholakalayil J, Coplan PM
Postgrad Med 2017 Jan;129(1):62-68. doi: 10.1080/00325481.2016.1271698. PMID: 27977317
Maharao NV, Joshi AA, Gerk PM
Biopharm Drug Dispos 2017 Mar;38(2):139-154. Epub 2017 Jan 24 doi: 10.1002/bdd.2050. PMID: 27925249
Bastian JR, Chen H, Zhang H, Rothenberger S, Tarter R, English D, Venkataramanan R, Caritis SN
Am J Obstet Gynecol 2017 Jan;216(1):64.e1-64.e7. Epub 2016 Sep 26 doi: 10.1016/j.ajog.2016.09.095. PMID: 27687214Free PMC Article
Walsh SL, Nuzzo PA, Babalonis S, Casselton V, Lofwall MR
Drug Alcohol Depend 2016 May 1;162:190-8. Epub 2016 Mar 14 doi: 10.1016/j.drugalcdep.2016.03.005. PMID: 27012435Free PMC Article

Recent systematic reviews

Kelty E, Hulse G
Drugs 2017 Jul;77(11):1199-1210. doi: 10.1007/s40265-017-0762-9. PMID: 28536980
Gowing L, Ali R, White JM, Mbewe D
Cochrane Database Syst Rev 2017 Feb 21;2:CD002025. doi: 10.1002/14651858.CD002025.pub5. PMID: 28220474
Noormohammadi A, Forinash A, Yancey A, Crannage E, Campbell K, Shyken J
Ann Pharmacother 2016 Aug;50(8):666-72. Epub 2016 May 19 doi: 10.1177/1060028016648367. PMID: 27199497
Bentzley BS, Barth KS, Back SE, Book SW
J Subst Abuse Treat 2015 May;52:48-57. Epub 2014 Dec 30 doi: 10.1016/j.jsat.2014.12.011. PMID: 25601365Free PMC Article
Cote J, Montgomery L
Pain Med 2014 Jul;15(7):1171-8. Epub 2014 Jul 4 doi: 10.1111/pme.12386. PMID: 24995716

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