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Items: 2

1.

Proton pump inhibitor

Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. [from NCI]

MedGen UID:
87634
Concept ID:
C0358591
Pharmacologic Substance
2.

Postmenopausal state

Having to do with the time after menopause. Menopause ("change of life") is the time in a woman's life when menstrual periods stop permanently. [from NCI_NCI-GLOSS]

MedGen UID:
65432
Concept ID:
C0232970
Finding

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