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Testosterone

MedGen UID:
21105
Concept ID:
C0039601
Hormone; Organic Chemical; Pharmacologic Substance
Synonyms: 17 beta Hydroxy 4 Androsten 3 one; 17-beta-Hydroxy-4-Androsten-3-one; Androst-4-en-17beta-ol-3-one
SNOMED CT: Testosterone product (109033004); Testosterone preparation (109033004); Testosterone (109033004); Testosterone (43688007)
 

Definition

A synthetic form of the endogenous androgenic steroid testosterone. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. This agent and its derivatives promote the maintenance of male sex characteristics. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862" NCI Thesaurus) [from PDQ]

Recent clinical studies

Etiology

Dias JP, Veldhuis JD, Carlson O, Shardell M, Chia CW, Melvin D, Egan JM, Basaria S
Metabolism 2017 Apr;69:143-147. Epub 2017 Jan 19 doi: 10.1016/j.metabol.2017.01.025. PMID: 28285644
Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk-Ware R, Nieschlag E
Andrology 2017 May;5(3):516-526. Epub 2017 Feb 11 doi: 10.1111/andr.12328. PMID: 28189123
Alexander GC, Iyer G, Lucas E, Lin D, Singh S
Am J Med 2017 Mar;130(3):293-305. Epub 2016 Oct 14 doi: 10.1016/j.amjmed.2016.09.017. PMID: 27751897
Debruyne FM, Behre HM, Roehrborn CG, Maggi M, Wu FC, Schröder FH, Jones TH, Porst H, Hackett G, Wheaton OA, Martin-Morales A, Meuleman E, Cunningham GR, Divan HA, Rosen RC; RHYME Investigators.
BJU Int 2017 Feb;119(2):216-224. Epub 2016 Aug 14 doi: 10.1111/bju.13578. PMID: 27409523
Shore ND, Chu F, Moul J, Saltzstein D, Concepcion R, McLane JA, Atkinson S, Yang A, Crawford ED
BJU Int 2017 Feb;119(2):239-244. Epub 2016 Apr 16 doi: 10.1111/bju.13482. PMID: 26991743

Diagnosis

Yilmaz Ö, Temur M, Calan M, Kume T, Özbay PÖ, Karakulak M, Yapucu S
Endokrynol Pol 2017;68(1):7-12. doi: 10.5603/EP.2017.0002. PMID: 28255975
Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk-Ware R, Nieschlag E
Andrology 2017 May;5(3):516-526. Epub 2017 Feb 11 doi: 10.1111/andr.12328. PMID: 28189123
Debruyne FM, Behre HM, Roehrborn CG, Maggi M, Wu FC, Schröder FH, Jones TH, Porst H, Hackett G, Wheaton OA, Martin-Morales A, Meuleman E, Cunningham GR, Divan HA, Rosen RC; RHYME Investigators.
BJU Int 2017 Feb;119(2):216-224. Epub 2016 Aug 14 doi: 10.1111/bju.13578. PMID: 27409523
Gururani K, Jose J, George PV
Indian Heart J 2016 Dec;68 Suppl 3:S16-S20. Epub 2016 Aug 8 doi: 10.1016/j.ihj.2016.07.002. PMID: 28038719Free PMC Article
Castelló-Porcar AM, Martínez-Jabaloyas JM
Aging Male 2016 Dec;19(4):254-258. Epub 2016 Nov 23 doi: 10.1080/13685538.2016.1253672. PMID: 27876434

Therapy

Dias JP, Veldhuis JD, Carlson O, Shardell M, Chia CW, Melvin D, Egan JM, Basaria S
Metabolism 2017 Apr;69:143-147. Epub 2017 Jan 19 doi: 10.1016/j.metabol.2017.01.025. PMID: 28285644
Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk-Ware R, Nieschlag E
Andrology 2017 May;5(3):516-526. Epub 2017 Feb 11 doi: 10.1111/andr.12328. PMID: 28189123
Alexander GC, Iyer G, Lucas E, Lin D, Singh S
Am J Med 2017 Mar;130(3):293-305. Epub 2016 Oct 14 doi: 10.1016/j.amjmed.2016.09.017. PMID: 27751897
Debruyne FM, Behre HM, Roehrborn CG, Maggi M, Wu FC, Schröder FH, Jones TH, Porst H, Hackett G, Wheaton OA, Martin-Morales A, Meuleman E, Cunningham GR, Divan HA, Rosen RC; RHYME Investigators.
BJU Int 2017 Feb;119(2):216-224. Epub 2016 Aug 14 doi: 10.1111/bju.13578. PMID: 27409523
Shore ND, Chu F, Moul J, Saltzstein D, Concepcion R, McLane JA, Atkinson S, Yang A, Crawford ED
BJU Int 2017 Feb;119(2):239-244. Epub 2016 Apr 16 doi: 10.1111/bju.13482. PMID: 26991743

Prognosis

Alexander GC, Iyer G, Lucas E, Lin D, Singh S
Am J Med 2017 Mar;130(3):293-305. Epub 2016 Oct 14 doi: 10.1016/j.amjmed.2016.09.017. PMID: 27751897
Debruyne FM, Behre HM, Roehrborn CG, Maggi M, Wu FC, Schröder FH, Jones TH, Porst H, Hackett G, Wheaton OA, Martin-Morales A, Meuleman E, Cunningham GR, Divan HA, Rosen RC; RHYME Investigators.
BJU Int 2017 Feb;119(2):216-224. Epub 2016 Aug 14 doi: 10.1111/bju.13578. PMID: 27409523
Gururani K, Jose J, George PV
Indian Heart J 2016 Dec;68 Suppl 3:S16-S20. Epub 2016 Aug 8 doi: 10.1016/j.ihj.2016.07.002. PMID: 28038719Free PMC Article
Fiamegos A, Varkarakis J, Kontraros M, Karagiannis A, Chrisofos M, Barbalias D, Deliveliotis C
Int Braz J Urol 2016 Sep-Oct;42(5):925-931. PMID: 27532110Free PMC Article
Kim SW, Hwang IC, Ahn HK, Kyung SY, Ahn HY
Am J Hosp Palliat Care 2016 Jun;33(5):483-8. Epub 2015 Feb 23 doi: 10.1177/1049909115574492. PMID: 25712105

Clinical prediction guides

Alexander GC, Iyer G, Lucas E, Lin D, Singh S
Am J Med 2017 Mar;130(3):293-305. Epub 2016 Oct 14 doi: 10.1016/j.amjmed.2016.09.017. PMID: 27751897
Debruyne FM, Behre HM, Roehrborn CG, Maggi M, Wu FC, Schröder FH, Jones TH, Porst H, Hackett G, Wheaton OA, Martin-Morales A, Meuleman E, Cunningham GR, Divan HA, Rosen RC; RHYME Investigators.
BJU Int 2017 Feb;119(2):216-224. Epub 2016 Aug 14 doi: 10.1111/bju.13578. PMID: 27409523
Gururani K, Jose J, George PV
Indian Heart J 2016 Dec;68 Suppl 3:S16-S20. Epub 2016 Aug 8 doi: 10.1016/j.ihj.2016.07.002. PMID: 28038719Free PMC Article
Martinez C, Suissa S, Rietbrock S, Katholing A, Freedman B, Cohen AT, Handelsman DJ
BMJ 2016 Nov 30;355:i5968. PMID: 27903495Free PMC Article
Enatsu N, Miyake H, Haraguchi T, Chiba K, Fujisawa M
Andrologia 2016 Dec;48(10):1195-1201. Epub 2016 Mar 8 doi: 10.1111/and.12560. PMID: 26952737

Recent systematic reviews

Alexander GC, Iyer G, Lucas E, Lin D, Singh S
Am J Med 2017 Mar;130(3):293-305. Epub 2016 Oct 14 doi: 10.1016/j.amjmed.2016.09.017. PMID: 27751897
Boyle P, Koechlin A, Bota M, d'Onofrio A, Zaridze DG, Perrin P, Fitzpatrick J, Burnett AL, Boniol M
BJU Int 2016 Nov;118(5):731-741. Epub 2016 Feb 24 doi: 10.1111/bju.13417. PMID: 26779889
Zhao J, Leung JY, Lin SL, Schooling CM
Prev Med 2016 Apr;85:1-10. Epub 2016 Jan 4 doi: 10.1016/j.ypmed.2015.12.021. PMID: 26763163
Dimopoulou C, Ceausu I, Depypere H, Lambrinoudaki I, Mueck A, Pérez-López FR, Rees M, van der Schouw YT, Senturk LM, Simonsini T, Stevenson JC, Stute P, Goulis DG
Maturitas 2016 Feb;84:94-9. Epub 2015 Nov 10 doi: 10.1016/j.maturitas.2015.11.003. PMID: 26614257
Lv W, Du N, Liu Y, Fan X, Wang Y, Jia X, Hou X, Wang B
Mol Neurobiol 2016 May;53(4):2679-84. Epub 2015 Jul 8 doi: 10.1007/s12035-015-9315-y. PMID: 26154489

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