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Items: 7

1.

Tuberculosis

A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. [from NCI]

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
2.

Causative_agents

Definition: A factor, such as a microorganism, chemical substance, or form of radiation, whose presence, excessive presence, or (in deficiency diseases) relative absence is essential, in whole or in part, for the occurrence of a condition. Constraint: The use of this participation is limited to observations.  [from HL7]

MedGen UID:
623004
Concept ID:
C0449411
Finding
3.

Cranioosteoarthropathy

A form of primary hypertrophic osteoarthropathy with characteristics of delayed closure of the cranial sutures and fontanelles, digital clubbing, arthropathy, and periostosis. To date, about 30 cases have been reported. May also be associated with congenital heart disease. It is caused by mutations in the HPGD gene (4q33-q34) and is inherited as an autosomal recessive trait. [from SNOMEDCT_US]

MedGen UID:
394824
Concept ID:
C2678439
Disease or Syndrome
4.

Macrolide

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties. [from MeSH]

MedGen UID:
129193
Concept ID:
C0282563
Organic Chemical; Pharmacologic Substance
5.

Polyketides

Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis. [from MeSH]

MedGen UID:
465520
Concept ID:
C3179052
Organic Chemical; Pharmacologic Substance
6.

Antimicrobial substance

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209727
Concept ID:
C1136254
Pharmacologic Substance
7.

Anti-infective agent

A pharmacological agent that can kill or prevent the reproduction of infectious organisms. [from NCI]

MedGen UID:
324
Concept ID:
C0003204
Pharmacologic Substance
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