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varenicline

MedGen UID:
292288
Concept ID:
C1569608
Organic Chemical; Pharmacologic Substance
Synonyms: 6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)benzazepine; Varenicline
SNOMED CT: Varenicline (421772003); Varenicline (420507002)
 

Definition

A benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVvarenicline

Recent clinical studies

Etiology

Kautiainen K, Ekroos H, Puhakka M, Liira H, Laine J, Linden K, Hahl J
J Med Econ 2017 Mar;20(3):246-252. Epub 2016 Nov 4 doi: 10.1080/13696998.2016.1249485. PMID: 27754739
Tonstad S, Lawrence D
J Diabetes Investig 2017 Jan;8(1):93-100. Epub 2016 Jul 14 doi: 10.1111/jdi.12543. PMID: 27223809Free PMC Article
Raich A, Ballbè M, Nieva G, Cano M, Fernández T, Bruguera E, Fernández E
Subst Use Misuse 2016;51(5):649-57. Epub 2016 Apr 6 doi: 10.3109/10826084.2015.1133646. PMID: 27050328
Sterling LH, Windle SB, Filion KB, Touma L, Eisenberg MJ
J Am Heart Assoc 2016 Feb 22;5(2) doi: 10.1161/JAHA.115.002849. PMID: 26903004Free PMC Article
Pascual FP, Fontoba Ferrándiz J, Gil Sanchez MC, Ponce Lorenzo F, Botella Estrella C
Subst Use Misuse 2016 Jan 28;51(2):131-40. Epub 2016 Feb 1 doi: 10.3109/10826084.2015.1018547. PMID: 26829065

Diagnosis

Kautiainen K, Ekroos H, Puhakka M, Liira H, Laine J, Linden K, Hahl J
J Med Econ 2017 Mar;20(3):246-252. Epub 2016 Nov 4 doi: 10.1080/13696998.2016.1249485. PMID: 27754739
Verplaetse TL, Pittman BP, Shi JM, Tetrault JM, Coppola S, McKee SA
J Addict Med 2016 May-Jun;10(3):166-73. doi: 10.1097/ADM.0000000000000208. PMID: 27159341Free PMC Article
Sterling LH, Windle SB, Filion KB, Touma L, Eisenberg MJ
J Am Heart Assoc 2016 Feb 22;5(2) doi: 10.1161/JAHA.115.002849. PMID: 26903004Free PMC Article
Yang M, Chen H, Johnson ML, Essien EJ, Peters RJ, Wu IH, Abughosh SM
Subst Use Misuse 2015;50(13):1628-37. Epub 2015 Nov 23 doi: 10.3109/10826084.2015.1023457. PMID: 26595661
de Bejczy A, Löf E, Walther L, Guterstam J, Hammarberg A, Asanovska G, Franck J, Isaksson A, Söderpalm B
Alcohol Clin Exp Res 2015 Nov;39(11):2189-99. Epub 2015 Sep 28 doi: 10.1111/acer.12854. PMID: 26414337

Therapy

Tervonen HE, Turunen JHO, Baker CL, Laine J, Linden K
BMC Public Health 2017 Apr 19;17(1):331. doi: 10.1186/s12889-017-4248-1. PMID: 28420395Free PMC Article
Hone AJ, Michael McIntosh J, Rueda-Ruzafa L, Passas J, de Castro-Guerín C, Blázquez J, González-Enguita C, Albillos A
J Neurochem 2017 Jan;140(1):37-52. Epub 2016 Dec 9 doi: 10.1111/jnc.13883. PMID: 27805736Free PMC Article
Kautiainen K, Ekroos H, Puhakka M, Liira H, Laine J, Linden K, Hahl J
J Med Econ 2017 Mar;20(3):246-252. Epub 2016 Nov 4 doi: 10.1080/13696998.2016.1249485. PMID: 27754739
Tonstad S, Lawrence D
J Diabetes Investig 2017 Jan;8(1):93-100. Epub 2016 Jul 14 doi: 10.1111/jdi.12543. PMID: 27223809Free PMC Article
Sterling LH, Windle SB, Filion KB, Touma L, Eisenberg MJ
J Am Heart Assoc 2016 Feb 22;5(2) doi: 10.1161/JAHA.115.002849. PMID: 26903004Free PMC Article

Prognosis

Eisenberg MJ, Windle SB, Roy N, Old W, Grondin FR, Bata I, Iskander A, Lauzon C, Srivastava N, Clarke A, Cassavar D, Dion D, Haught H, Mehta SR, Baril JF, Lambert C, Madan M, Abramson BL, Dehghani P; EVITA Investigators.
Circulation 2016 Jan 5;133(1):21-30. Epub 2015 Nov 9 doi: 10.1161/CIRCULATIONAHA.115.019634. PMID: 26553744
Yang M, Chen H, Johnson ML, Essien EJ, Peters RJ, Wu IH, Abughosh SM
Subst Use Misuse 2015;50(13):1628-37. Epub 2015 Nov 23 doi: 10.3109/10826084.2015.1023457. PMID: 26595661
Windle SB, Bata I, Madan M, Abramson BL, Eisenberg MJ
Am Heart J 2015 Oct;170(4):635-640.e1. Epub 2015 Jul 17 doi: 10.1016/j.ahj.2015.07.010. PMID: 26386786
Shelley D, Tseng TY, Gonzalez M, Krebs P, Wong S, Furberg R, Sherman S, Schoenthaler A, Urbina A, Cleland CM
Nicotine Tob Res 2015 Aug;17(8):968-74. doi: 10.1093/ntr/ntv068. PMID: 26180221Free PMC Article
Gray KM, McClure EA, Baker NL, Hartwell KJ, Carpenter MJ, Saladin ME
Addiction 2015 Jun;110(6):1027-34. Epub 2015 Mar 29 doi: 10.1111/add.12895. PMID: 25727442Free PMC Article

Clinical prediction guides

Sterling LH, Windle SB, Filion KB, Touma L, Eisenberg MJ
J Am Heart Assoc 2016 Feb 22;5(2) doi: 10.1161/JAHA.115.002849. PMID: 26903004Free PMC Article
Pascual FP, Fontoba Ferrándiz J, Gil Sanchez MC, Ponce Lorenzo F, Botella Estrella C
Subst Use Misuse 2016 Jan 28;51(2):131-40. Epub 2016 Feb 1 doi: 10.3109/10826084.2015.1018547. PMID: 26829065
Westergaard CG, Porsbjerg C, Backer V
Respir Med 2015 Nov;109(11):1416-22. Epub 2015 Jul 30 doi: 10.1016/j.rmed.2015.07.017. PMID: 26427627
de Bejczy A, Löf E, Walther L, Guterstam J, Hammarberg A, Asanovska G, Franck J, Isaksson A, Söderpalm B
Alcohol Clin Exp Res 2015 Nov;39(11):2189-99. Epub 2015 Sep 28 doi: 10.1111/acer.12854. PMID: 26414337
Shewale AR, Borse MS, Brown JD, Li C
Drug Alcohol Depend 2015 Sep 1;154:132-8. Epub 2015 Jun 27 doi: 10.1016/j.drugalcdep.2015.06.028. PMID: 26169448

Recent systematic reviews

Sterling LH, Windle SB, Filion KB, Touma L, Eisenberg MJ
J Am Heart Assoc 2016 Feb 22;5(2) doi: 10.1161/JAHA.115.002849. PMID: 26903004Free PMC Article
Vogeler T, McClain C, Evoy KE
Am J Drug Alcohol Abuse 2016 Mar;42(2):129-39. Epub 2016 Jan 25 doi: 10.3109/00952990.2015.1117480. PMID: 26809272
McKee SA, Smith PH, Kaufman M, Mazure CM, Weinberger AH
Nicotine Tob Res 2016 May;18(5):1002-11. Epub 2015 Oct 6 doi: 10.1093/ntr/ntv207. PMID: 26446070
Hughes JR
Nicotine Tob Res 2016 Jan;18(1):2-9. Epub 2015 Jan 8 doi: 10.1093/ntr/ntu275. PMID: 25572451
Agboola SA, Coleman T, McNeill A, Leonardi-Bee J
Addiction 2015 Jul;110(7):1182-93. doi: 10.1111/add.12941. PMID: 25846123

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