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Hypothermia

MedGen UID:
5720
Concept ID:
C0020672
Finding; Finding
Synonyms: Abnormally low body temperature
SNOMED CT: Hypothermia (386689009); Body temperature below normal (386689009); Decreased body temperature (386689009); State of hypothermia (386689009); Temperature subnormal (386689009)
 
HPO: HP:0002045

Definition

Cold weather can affect your body in different ways. You can get frostbite, which is frozen body tissue. Your body can also lose heat faster than you can produce it. The result is hypothermia, or abnormally low body temperature. It can make you sleepy, confused and clumsy. Because it happens gradually and affects your thinking, you may not realize you need help. That makes it especially dangerous. A body temperature below 95![DEGREE SIGN]! F is a medical emergency and can lead to death if not treated promptly. . Anyone who spends much time outdoors in cold weather can get hypothermia. You can also get it from being cold and wet, or under cold water for too long. Babies and old people are especially at risk. Babies can get it from sleeping in a cold room. . Centers for Disease Control and Prevention.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypothermia

Conditions with this feature

Menkes kinky-hair syndrome
MedGen UID:
44030
Concept ID:
C0022716
Disease or Syndrome
Menkes disease is an X-linked recessive disorder characterized by generalized copper deficiency. The clinical features result from the dysfunction of several copper-dependent enzymes. De Bie et al. (2007) provided a detailed review of the molecular pathogenesis of Menkes disease.
Thyroid agenesis
MedGen UID:
289647
Concept ID:
C1563716
Congenital Abnormality
In 80 to 85% of cases, congenital hypothyroidism is associated with, and presumably is a consequence of, thyroid dysgenesis (Macchia et al., 1998). In these cases, the thyroid gland can be absent (agenesis), ectopically located, and/or severely reduced in size (hypoplasia). When thyroid hormone therapy is not initiated within the first 2 months of life, congenital hypothyroidism can cause severe neurologic, mental, and motor damage (cretinism).
Deficiency of 2-methylbutyryl-CoA dehydrogenase
MedGen UID:
355324
Concept ID:
C1864912
Disease or Syndrome
2-Methylbutyryl-CoA dehydrogenase (MBD) deficiency is an autosomal recessive metabolic disorder of impaired isoleucine degradation. It is most often ascertained via newborn screening and is usually clinically asymptomatic, although some patients have been reported to have delayed development and neurologic signs. Therefore, the clinical relevance of the deficiency is unclear (Sass et al.., 2008).
Mitochondrial DNA-depletion syndrome 3, hepatocerebral
MedGen UID:
462863
Concept ID:
C3151513
Disease or Syndrome
The two forms of deoxyguanosine kinase (DGUOK) deficiency are a neonatal multisystem disorder and an isolated hepatic disorder that presents later in infancy or childhood. The majority of affected individuals have the multisystem illness with hepatic disease (jaundice, cholestasis, hepatomegaly, and elevated transaminases) and neurologic manifestations (hypotonia, nystagmus, and psychomotor retardation) evident within weeks of birth. Those with isolated liver disease may also have renal involvement and some later develop mild hypotonia. Progressive hepatic disease is the most common cause of death in both forms.

Recent clinical studies

Etiology

Samoila G, Ford RT, Glasbey JC, Lewis MH, Twine CP, Williams IM
Ann Vasc Surg 2017 Jan;38:323-331. Epub 2016 Aug 13 doi: 10.1016/j.avsg.2016.05.121. PMID: 27531090
Batycka-Stachnik D, Piwoda A, Darocha T, Spiewak M, Kosinski S, Jarosz A, Hymczak H, Sanak T, Galazkowski R, Piatek J, Konstanty-Kalandyk J, Drwila R
Wiad Lek 2016;69(3 pt 2):489-494. PMID: 27717931
Frisch NB, Pepper AM, Jildeh TR, Shaw J, Guthrie T, Silverton C
Orthopedics 2016 Nov 1;39(6):e1170-e1177. Epub 2016 Aug 18 doi: 10.3928/01477447-20160811-04. PMID: 27536952
John M, Crook D, Dasari K, Eljelani F, El-Haboby A, Harper CM
Br J Anaesth 2016 Feb;116(2):249-54. doi: 10.1093/bja/aev412. PMID: 26787794
Van Poucke S, Stevens K, Kicken C, Simons A, Marcus A, Lancé M
Artif Organs 2016 Mar;40(3):288-93. Epub 2015 Sep 28 doi: 10.1111/aor.12555. PMID: 26411987

Diagnosis

Zafren K
Emerg Med Clin North Am 2017 May;35(2):261-279. doi: 10.1016/j.emc.2017.01.003. PMID: 28411927
Samoila G, Ford RT, Glasbey JC, Lewis MH, Twine CP, Williams IM
Ann Vasc Surg 2017 Jan;38:323-331. Epub 2016 Aug 13 doi: 10.1016/j.avsg.2016.05.121. PMID: 27531090
Hervet T, Teresiński G, Hejna P, Descloux E, Grouzmann E, Palmiere C
Forensic Sci Med Pathol 2016 Jun;12(2):163-9. Epub 2016 Mar 26 doi: 10.1007/s12024-016-9764-2. PMID: 27017494
Perich P, Tuchtan L, Bartoli C, Léonetti G, Piercecchi-Marti MD
J Forensic Sci 2016 Mar;61(2):562-5. Epub 2015 Nov 9 doi: 10.1111/1556-4029.12981. PMID: 26551786
Darocha T, Kosinski S, Moskwa M, Jarosz A, Sobczyk D, Galazkowski R, Slowik M, Drwila R
High Alt Med Biol 2015 Dec;16(4):352-5. Epub 2015 Aug 24 doi: 10.1089/ham.2015.0055. PMID: 26301723Free PMC Article

Therapy

Samoila G, Ford RT, Glasbey JC, Lewis MH, Twine CP, Williams IM
Ann Vasc Surg 2017 Jan;38:323-331. Epub 2016 Aug 13 doi: 10.1016/j.avsg.2016.05.121. PMID: 27531090
Dietrichs ES, Sager G, Tveita T
Scand J Trauma Resusc Emerg Med 2016 Dec 5;24(1):143. doi: 10.1186/s13049-016-0339-8. PMID: 27919274Free PMC Article
Batycka-Stachnik D, Piwoda A, Darocha T, Spiewak M, Kosinski S, Jarosz A, Hymczak H, Sanak T, Galazkowski R, Piatek J, Konstanty-Kalandyk J, Drwila R
Wiad Lek 2016;69(3 pt 2):489-494. PMID: 27717931
Liu K, Khan H, Geng X, Zhang J, Ding Y
Neurol Res 2016 Jun;38(6):478-90. doi: 10.1080/01616412.2016.1187826. PMID: 27320243
John M, Crook D, Dasari K, Eljelani F, El-Haboby A, Harper CM
Br J Anaesth 2016 Feb;116(2):249-54. doi: 10.1093/bja/aev412. PMID: 26787794

Prognosis

Samoila G, Ford RT, Glasbey JC, Lewis MH, Twine CP, Williams IM
Ann Vasc Surg 2017 Jan;38:323-331. Epub 2016 Aug 13 doi: 10.1016/j.avsg.2016.05.121. PMID: 27531090
Frisch NB, Pepper AM, Jildeh TR, Shaw J, Guthrie T, Silverton C
Orthopedics 2016 Nov 1;39(6):e1170-e1177. Epub 2016 Aug 18 doi: 10.3928/01477447-20160811-04. PMID: 27536952
Vardon F, Mrozek S, Geeraerts T, Fourcade O
Anaesth Crit Care Pain Med 2016 Oct;35(5):355-361. Epub 2016 May 13 doi: 10.1016/j.accpm.2016.05.001. PMID: 27185009
Perich P, Tuchtan L, Bartoli C, Léonetti G, Piercecchi-Marti MD
J Forensic Sci 2016 Mar;61(2):562-5. Epub 2015 Nov 9 doi: 10.1111/1556-4029.12981. PMID: 26551786
Darocha T, Kosinski S, Moskwa M, Jarosz A, Sobczyk D, Galazkowski R, Slowik M, Drwila R
High Alt Med Biol 2015 Dec;16(4):352-5. Epub 2015 Aug 24 doi: 10.1089/ham.2015.0055. PMID: 26301723Free PMC Article

Clinical prediction guides

Horn EP, Bein B, Broch O, Iden T, Böhm R, Latz SK, Höcker J
Eur J Anaesthesiol 2016 May;33(5):334-40. doi: 10.1097/EJA.0000000000000369. PMID: 26555870
Van Poucke S, Stevens K, Kicken C, Simons A, Marcus A, Lancé M
Artif Organs 2016 Mar;40(3):288-93. Epub 2015 Sep 28 doi: 10.1111/aor.12555. PMID: 26411987
Conway A, Kennedy W, Sutherland J
J Cardiothorac Vasc Anesth 2015 Oct;29(5):1285-90. Epub 2015 Jun 6 doi: 10.1053/j.jvca.2015.06.002. PMID: 26384630
Darocha T, Kosinski S, Moskwa M, Jarosz A, Sobczyk D, Galazkowski R, Slowik M, Drwila R
High Alt Med Biol 2015 Dec;16(4):352-5. Epub 2015 Aug 24 doi: 10.1089/ham.2015.0055. PMID: 26301723Free PMC Article
Debaty G, Moustapha I, Bouzat P, Maignan M, Blancher M, Rallo A, Brun J, Chavanon O, Danel V, Carpentier F, Payen JF, Briot R
Resuscitation 2015 Aug;93:118-23. Epub 2015 Jun 19 doi: 10.1016/j.resuscitation.2015.06.013. PMID: 26095302

Recent systematic reviews

Warttig S, Alderson P, Lewis SR, Smith AF
Cochrane Database Syst Rev 2016 Nov 22;11:CD009906. doi: 10.1002/14651858.CD009906.pub2. PMID: 27875631
Madrid E, Urrútia G, Roqué i Figuls M, Pardo-Hernandez H, Campos JM, Paniagua P, Maestre L, Alonso-Coello P
Cochrane Database Syst Rev 2016 Apr 21;4:CD009016. doi: 10.1002/14651858.CD009016.pub2. PMID: 27098439
Spencer JM, Sheridan SC
Perspect Public Health 2015 Mar;135(2):85-91. Epub 2014 Feb 14 doi: 10.1177/1757913913517977. PMID: 24532173
Zafren K, Giesbrecht GG, Danzl DF, Brugger H, Sagalyn EB, Walpoth B, Weiss EA, Auerbach PS, McIntosh SE, Némethy M, McDevitt M, Dow J, Schoene RB, Rodway GW, Hackett PH, Bennett BL, Grissom CK; Wilderness Medical Society.
Wilderness Environ Med 2014 Dec;25(4 Suppl):S66-85. doi: 10.1016/j.wem.2014.10.010. PMID: 25498264
Warttig S, Alderson P, Campbell G, Smith AF
Cochrane Database Syst Rev 2014 Nov 20;(11):CD009892. doi: 10.1002/14651858.CD009892.pub2. PMID: 25411963

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