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Tyrosine

MedGen UID:
21746
Concept ID:
C0041485
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
Synonyms: L Tyrosine; L-Tyrosine; para Tyrosine; para-Tyrosine; Tyrosine, L isomer; Tyrosine, L-isomer
SNOMED CT: Tyrosine (418246001); L-Tyrosine (27378009); Tyrosine (27378009)
 

Definition

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTyrosine

Recent clinical studies

Etiology

Milan AM, Hughes AT, Davison AS, Devine J, Usher J, Curtis S, Khedr M, Gallagher JA, Ranganath LR
Ann Clin Biochem 2017 May;54(3):323-330. Epub 2017 Mar 16 doi: 10.1177/0004563217691065. PMID: 28081634
Aluri R, Jayakannan M
Biomacromolecules 2017 Jan 9;18(1):189-200. Epub 2016 Dec 8 doi: 10.1021/acs.biomac.6b01476. PMID: 28064504
Sundarakrishnan A, Herrero Acero E, Coburn J, Chwalek K, Partlow B, Kaplan DL
Acta Biomater 2016 Sep 15;42:102-113. Epub 2016 Jun 23 doi: 10.1016/j.actbio.2016.06.020. PMID: 27345138
Szélig L, Kun S, Woth G, Molnár GA, Zrínyi Z, Kátai E, Lantos J, Wittmann I, Bogár L, Miseta A, Csontos C
Redox Rep 2016 Jul;21(4):180-9. Epub 2016 Jun 18 doi: 10.1179/1351000215Y.0000000028. PMID: 26193242
Al-Momani E, Israel I, Buck AK, Samnick S
Appl Radiat Isot 2015 Oct;104:136-42. Epub 2015 Jun 20 doi: 10.1016/j.apradiso.2015.06.021. PMID: 26159662

Diagnosis

Batthyány C, Bartesaghi S, Mastrogiovanni M, Lima A, Demicheli V, Radi R
Antioxid Redox Signal 2017 Mar 1;26(7):313-328. Epub 2016 Jul 22 doi: 10.1089/ars.2016.6787. PMID: 27324931Free PMC Article
Ng SP, Qiu G, Ding N, Lu X, Wu CL
Biosens Bioelectron 2017 Mar 15;89(Pt 1):468-476. Epub 2016 Apr 7 doi: 10.1016/j.bios.2016.04.017. PMID: 27085521
Gu L, Hou P, Zhang R, Liu Z, Bi K, Chen X
J Chromatogr B Analyt Technol Biomed Life Sci 2016 Oct 15;1033-1034:157-165. Epub 2016 Aug 16 doi: 10.1016/j.jchromb.2016.08.021. PMID: 27561182
Kan WC, Lu TL, Ling P, Lee TH, Cho CY, Huang CY, Jeng WY, Weng YP, Chiang CY, Wu JB, Lu TJ
J Inorg Biochem 2016 Jul;160:33-9. Epub 2016 Apr 13 doi: 10.1016/j.jinorgbio.2016.04.013. PMID: 27118027
Wu Q, Fang A, Li H, Zhang Y, Yao S
Biosens Bioelectron 2016 Mar 15;77:957-62. Epub 2015 Oct 30 doi: 10.1016/j.bios.2015.10.084. PMID: 26544870

Therapy

Milan AM, Hughes AT, Davison AS, Devine J, Usher J, Curtis S, Khedr M, Gallagher JA, Ranganath LR
Ann Clin Biochem 2017 May;54(3):323-330. Epub 2017 Mar 16 doi: 10.1177/0004563217691065. PMID: 28081634
Aluri R, Jayakannan M
Biomacromolecules 2017 Jan 9;18(1):189-200. Epub 2016 Dec 8 doi: 10.1021/acs.biomac.6b01476. PMID: 28064504
Attipoe S, Zeno SA, Lee C, Crawford C, Khorsan R, Walter AR, Deuster PA
Mil Med 2015 Jul;180(7):754-65. doi: 10.7205/MILMED-D-14-00594. PMID: 26126245
Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G
Oncotarget 2015 May 30;6(15):13320-33. doi: 10.18632/oncotarget.3645. PMID: 26079946Free PMC Article
Colzato LS, Jongkees BJ, Sellaro R, van den Wildenberg WP, Hommel B
Neuropsychologia 2014 Sep;62:398-402. Epub 2014 Jan 13 doi: 10.1016/j.neuropsychologia.2013.12.027. PMID: 24433977

Prognosis

Cheng J, Zheng G, Jin H, Gao X
Comb Chem High Throughput Screen 2017;20(2):133-139. doi: 10.2174/1386207319666161220115409. PMID: 28000565
Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA
Bioorg Med Chem Lett 2016 Jun 1;26(11):2616-2621. Epub 2016 Apr 11 doi: 10.1016/j.bmcl.2016.04.023. PMID: 27106710Free PMC Article
Szélig L, Kun S, Woth G, Molnár GA, Zrínyi Z, Kátai E, Lantos J, Wittmann I, Bogár L, Miseta A, Csontos C
Redox Rep 2016 Jul;21(4):180-9. Epub 2016 Jun 18 doi: 10.1179/1351000215Y.0000000028. PMID: 26193242
Pandya S, Struck TJ, Mannakee BK, Paniscus M, Gutenkunst RN
Mol Biol Evol 2015 Jan;32(1):144-52. Epub 2014 Oct 13 doi: 10.1093/molbev/msu284. PMID: 25312910Free PMC Article
Kun S, Mikolás E, Molnár GA, Sélley E, Laczy B, Csiky B, Kovács T, Wittmann I
Redox Rep 2014 Sep;19(5):190-8. Epub 2014 Apr 3 doi: 10.1179/1351000214Y.0000000090. PMID: 24693974

Clinical prediction guides

Cheng J, Zheng G, Jin H, Gao X
Comb Chem High Throughput Screen 2017;20(2):133-139. doi: 10.2174/1386207319666161220115409. PMID: 28000565
Gu L, Hou P, Zhang R, Liu Z, Bi K, Chen X
J Chromatogr B Analyt Technol Biomed Life Sci 2016 Oct 15;1033-1034:157-165. Epub 2016 Aug 16 doi: 10.1016/j.jchromb.2016.08.021. PMID: 27561182
Dunning CJ, Black HL, Andrews KL, Davenport EC, Conboy M, Chawla S, Dowle AA, Ashford D, Thomas JR, Evans GJ
J Neurochem 2016 May;137(4):518-27. Epub 2016 Mar 1 doi: 10.1111/jnc.13571. PMID: 26865271Free PMC Article
Verma R, Venkatareddy M, Kalinowski A, Patel SR, Salant DJ, Garg P
Mol Cell Biol 2015 Dec 7;36(4):596-614. doi: 10.1128/MCB.00956-15. PMID: 26644409Free PMC Article
Hughes AT, Milan AM, Davison AS, Christensen P, Ross G, Gallagher JA, Dutton JJ, Ranganath LR
Ann Clin Biochem 2015 Sep;52(Pt 5):597-605. Epub 2015 Jan 27 doi: 10.1177/0004563215571969. PMID: 25628464

Recent systematic reviews

Lee RH, Bergmeier W
J Thromb Haemost 2016 Apr;14(4):645-54. Epub 2016 Feb 16 doi: 10.1111/jth.13250. PMID: 26749528
Attipoe S, Zeno SA, Lee C, Crawford C, Khorsan R, Walter AR, Deuster PA
Mil Med 2015 Jul;180(7):754-65. doi: 10.7205/MILMED-D-14-00594. PMID: 26126245
Hase A, Jung SE, aan het Rot M
Pharmacol Biochem Behav 2015 Jun;133:1-6. Epub 2015 Mar 20 doi: 10.1016/j.pbb.2015.03.008. PMID: 25797188
Wiggins T, Kumar S, Markar SR, Antonowicz S, Hanna GB
Cancer Epidemiol Biomarkers Prev 2015 Jan;24(1):32-8. Epub 2014 Oct 25 doi: 10.1158/1055-9965.EPI-14-0980. PMID: 25344892
Webster D, Wildgoose J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD001507. doi: 10.1002/14651858.CD001507.pub3. PMID: 23737086

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