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Metabolic syndrome X(AOMS1)

MedGen UID:
99356
Concept ID:
C0524620
Disease or Syndrome
Synonyms: Abdominal obesity metabolic syndrome; AOMS1
SNOMED CT: Insulin resistance syndrome (237602007); Metabolic syndrome (237602007); Dysmetabolic syndrome X (237602007); Metabolic syndrome X (237602007); Reaven's syndrome (237602007)
 
Gene (location): MTTP (4q23)
OMIM®: 605552

Definition

A clustering of abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol (HDLC), high blood pressure, and elevated fasting glucose levels is sometimes called metabolic syndrome X (Reaven, 1988) or abdominal obesity-metabolic syndrome (Bjorntorp, 1991). The syndrome may affect nearly 1 in 4 U.S. adults and is considered a veritable epidemic (Ford et al., 2002). It is a major risk factor for both diabetes mellitus (see 125853 and Haffner et al., 1992) and cardiovascular disease (Isomaa et al., 2001). The etiology is complex, determined by the interplay of both genetic and environmental factors. The prevalence varies substantially among ethnic groups, with the highest rates in Mexican American women (Park et al., 2003). Other factors influencing the metabolic syndrome include age, smoking, alcohol, diet, and physical inactivity. Genetic Heterogeneity of Abdominal Obesity-Metabolic Syndrome AOMS2 (605572) has been mapped to chromosome 17p12. AOMS3 (615812) is caused by mutation in the DYRK1B gene (604556) on chromosome 19q13. [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic syndrome X

Recent clinical studies

Etiology

Boer H, Westerink ND, Altena R, Nuver J, Dijck-Brouwer DA, van Faassen M, Klont F, Kema IP, Lefrandt JD, Zwart N, Boezen HM, Smit AJ, Meijer C, Gietema JA
Eur J Cancer 2016 Feb;54:104-11. Epub 2016 Jan 2 doi: 10.1016/j.ejca.2015.11.009. [Epub ahead of print] PMID: 26751392
Vishnu A, Gurka MJ, DeBoer MD
Atherosclerosis 2015 Nov;243(1):278-85. Epub 2015 Sep 21 doi: 10.1016/j.atherosclerosis.2015.09.025. [Epub ahead of print] PMID: 26409627Free PMC Article
Earnest CP, Church TS
Metab Syndr Relat Disord 2015 Nov;13(9):406-14. Epub 2015 Aug 24 doi: 10.1089/met.2015.0075. [Epub ahead of print] PMID: 26302220
Patel PN, Shah RY, Ferguson JF, Reilly MP
Arterioscler Thromb Vasc Biol 2015 Mar;35(3):525-34. Epub 2014 Dec 30 doi: 10.1161/ATVBAHA.114.304455. [Epub ahead of print] PMID: 25550206Free PMC Article
Amihăesei IC, Chelaru L
Rev Med Chir Soc Med Nat Iasi 2014 Oct-Dec;118(4):896-900. PMID: 25581945

Diagnosis

Boer H, Westerink ND, Altena R, Nuver J, Dijck-Brouwer DA, van Faassen M, Klont F, Kema IP, Lefrandt JD, Zwart N, Boezen HM, Smit AJ, Meijer C, Gietema JA
Eur J Cancer 2016 Feb;54:104-11. Epub 2016 Jan 2 doi: 10.1016/j.ejca.2015.11.009. [Epub ahead of print] PMID: 26751392
Vishnu A, Gurka MJ, DeBoer MD
Atherosclerosis 2015 Nov;243(1):278-85. Epub 2015 Sep 21 doi: 10.1016/j.atherosclerosis.2015.09.025. [Epub ahead of print] PMID: 26409627Free PMC Article
Earnest CP, Church TS
Metab Syndr Relat Disord 2015 Nov;13(9):406-14. Epub 2015 Aug 24 doi: 10.1089/met.2015.0075. [Epub ahead of print] PMID: 26302220
Gao M, Chen W, Gong ZK, Han L, Zhang L
Panminerva Med 2015 Sep;57(3):115-9. Epub 2014 Dec 23 [Epub ahead of print] PMID: 25532607
Amihăesei IC, Chelaru L
Rev Med Chir Soc Med Nat Iasi 2014 Oct-Dec;118(4):896-900. PMID: 25581945

Therapy

Boer H, Westerink ND, Altena R, Nuver J, Dijck-Brouwer DA, van Faassen M, Klont F, Kema IP, Lefrandt JD, Zwart N, Boezen HM, Smit AJ, Meijer C, Gietema JA
Eur J Cancer 2016 Feb;54:104-11. Epub 2016 Jan 2 doi: 10.1016/j.ejca.2015.11.009. [Epub ahead of print] PMID: 26751392
Vishnu A, Gurka MJ, DeBoer MD
Atherosclerosis 2015 Nov;243(1):278-85. Epub 2015 Sep 21 doi: 10.1016/j.atherosclerosis.2015.09.025. [Epub ahead of print] PMID: 26409627Free PMC Article
Earnest CP, Church TS
Metab Syndr Relat Disord 2015 Nov;13(9):406-14. Epub 2015 Aug 24 doi: 10.1089/met.2015.0075. [Epub ahead of print] PMID: 26302220
Verloop WL, Spiering W, Vink EE, Beeftink MM, Blankestijn PJ, Doevendans PA, Voskuil M
Hypertension 2015 Apr;65(4):751-7. Epub 2015 Feb 2 doi: 10.1161/HYPERTENSIONAHA.114.04798. [Epub ahead of print] PMID: 25646297
Gao M, Chen W, Gong ZK, Han L, Zhang L
Panminerva Med 2015 Sep;57(3):115-9. Epub 2014 Dec 23 [Epub ahead of print] PMID: 25532607

Prognosis

Vishnu A, Gurka MJ, DeBoer MD
Atherosclerosis 2015 Nov;243(1):278-85. Epub 2015 Sep 21 doi: 10.1016/j.atherosclerosis.2015.09.025. [Epub ahead of print] PMID: 26409627Free PMC Article
Graziano F, Grassi M, Sacco S, Concas MP, Vaccargiu S, Pirastu M, Biino G
Nutr Metab Cardiovasc Dis 2015 Jun;25(6):548-55. Epub 2015 Feb 20 doi: 10.1016/j.numecd.2015.02.004. [Epub ahead of print] PMID: 25836955
Verloop WL, Spiering W, Vink EE, Beeftink MM, Blankestijn PJ, Doevendans PA, Voskuil M
Hypertension 2015 Apr;65(4):751-7. Epub 2015 Feb 2 doi: 10.1161/HYPERTENSIONAHA.114.04798. [Epub ahead of print] PMID: 25646297
Patel PN, Shah RY, Ferguson JF, Reilly MP
Arterioscler Thromb Vasc Biol 2015 Mar;35(3):525-34. Epub 2014 Dec 30 doi: 10.1161/ATVBAHA.114.304455. [Epub ahead of print] PMID: 25550206Free PMC Article
Gao M, Chen W, Gong ZK, Han L, Zhang L
Panminerva Med 2015 Sep;57(3):115-9. Epub 2014 Dec 23 [Epub ahead of print] PMID: 25532607

Clinical prediction guides

Vishnu A, Gurka MJ, DeBoer MD
Atherosclerosis 2015 Nov;243(1):278-85. Epub 2015 Sep 21 doi: 10.1016/j.atherosclerosis.2015.09.025. [Epub ahead of print] PMID: 26409627Free PMC Article
Graziano F, Grassi M, Sacco S, Concas MP, Vaccargiu S, Pirastu M, Biino G
Nutr Metab Cardiovasc Dis 2015 Jun;25(6):548-55. Epub 2015 Feb 20 doi: 10.1016/j.numecd.2015.02.004. [Epub ahead of print] PMID: 25836955
Verloop WL, Spiering W, Vink EE, Beeftink MM, Blankestijn PJ, Doevendans PA, Voskuil M
Hypertension 2015 Apr;65(4):751-7. Epub 2015 Feb 2 doi: 10.1161/HYPERTENSIONAHA.114.04798. [Epub ahead of print] PMID: 25646297
Patel PN, Shah RY, Ferguson JF, Reilly MP
Arterioscler Thromb Vasc Biol 2015 Mar;35(3):525-34. Epub 2014 Dec 30 doi: 10.1161/ATVBAHA.114.304455. [Epub ahead of print] PMID: 25550206Free PMC Article
Gao M, Chen W, Gong ZK, Han L, Zhang L
Panminerva Med 2015 Sep;57(3):115-9. Epub 2014 Dec 23 [Epub ahead of print] PMID: 25532607

Recent systematic reviews

Chen GC, Szeto IM, Chen LH, Han SF, Li YJ, van Hekezen R, Qin LQ
Sci Rep 2015 Sep 29;5:14606. doi: 10.1038/srep14606. PMID: 26416233Free PMC Article
Sperling LS, Mechanick JI, Neeland IJ, Herrick CJ, Després JP, Ndumele CE, Vijayaraghavan K, Handelsman Y, Puckrein GA, Araneta MR, Blum QK, Collins KK, Cook S, Dhurandhar NV, Dixon DL, Egan BM, Ferdinand DP, Herman LM, Hessen SE, Jacobson TA, Pate RR, Ratner RE, Brinton EA, Forker AD, Ritzenthaler LL, Grundy SM
J Am Coll Cardiol 2015 Sep 1;66(9):1050-67. doi: 10.1016/j.jacc.2015.06.1328. PMID: 26314534
Tie HT, Shi R, Li ZH, Zhang M, Zhang C, Wu QC
Metabolism 2015 Oct;64(10):1224-34. Epub 2015 Jul 2 doi: 10.1016/j.metabol.2015.06.019. [Epub ahead of print] PMID: 26231436
Loader J, Montero D, Lorenzen C, Watts R, Méziat C, Reboul C, Stewart S, Walther G
Arterioscler Thromb Vasc Biol 2015 Sep;35(9):2060-72. Epub 2015 Jun 25 doi: 10.1161/ATVBAHA.115.305530. [Epub ahead of print] PMID: 26112007
Kronenberg F, Kollerits B, Kiechl S, Lamina C, Kedenko L, Meisinger C, Willeit J, Huth C, Wietzorrek G, Altmann ME, Thorand B, Melmer A, Dähnhardt D, Santer P, Rathmann W, Paulweber B, Koenig W, Peters A, Adham IM, Dieplinger H
Circ Cardiovasc Genet 2014 Dec;7(6):822-9. Epub 2014 Aug 31 doi: 10.1161/CIRCGENETICS.113.000654. [Epub ahead of print] PMID: 25176938

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