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MUC1 Peptide-Poly-ICLC Vaccine

MedGen UID:
417383
Concept ID:
C2826163
Pharmacologic Substance
 

Definition

A vaccine preparation containing mucus 1 (MUC1) peptide and the adjuvant poly-ICLC with potential immunostimulatory and antineoplastic activities. Upon administration, MUC1 peptide-poly-ICLC adjuvant vaccine may induce the host immune system to mount a cytotoxic T cell response against MUC1-expressing tumor cells. MUC1, a tumor associated antigen normally present on the lining of the human colon, may be overexpressed and/or mutated in a variety of cancer cell types. The adjuvant poly-ICLC, a ligand for toll-like receptor-3, induces the release of cytokines which may help boost the immune response against MUC1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMUC1 Peptide-Poly-ICLC Vaccine

Recent clinical studies

Etiology

Vang DP, Wurz GT, Griffey SM, Kao CJ, Gutierrez AM, Hanson GK, Wolf M, DeGregorio MW
J Vis Exp 2013 Oct 30;(80):e50868. doi: 10.3791/50868. PMID: 24300078Free PMC Article
Sarkar S, Salyer AC, Wall KA, Sucheck SJ
Bioconjug Chem 2013 Mar 20;24(3):363-75. Epub 2013 Mar 8 doi: 10.1021/bc300422a. PMID: 23444835Free PMC Article
Kimura T, McKolanis JR, Dzubinski LA, Islam K, Potter DM, Salazar AM, Schoen RE, Finn OJ
Cancer Prev Res (Phila) 2013 Jan;6(1):18-26. Epub 2012 Dec 17 doi: 10.1158/1940-6207.CAPR-12-0275. PMID: 23248097Free PMC Article
Beatty PL, Narayanan S, Gariépy J, Ranganathan S, Finn OJ
Cancer Prev Res (Phila) 2010 Apr;3(4):438-46. Epub 2010 Mar 23 doi: 10.1158/1940-6207.CAPR-09-0194. PMID: 20332301Free PMC Article
Yuan S, Shi C, Han W, Ling R, Li N, Wang T
Eur J Cancer Prev 2009 Sep;18(5):416-23. doi: 10.1097/CEJ.0b013e32832c3882. PMID: 19550341

Diagnosis

Palitzsch B, Gaidzik N, Stergiou N, Stahn S, Hartmann S, Gerlitzki B, Teusch N, Flemming P, Schmitt E, Kunz H
Angew Chem Int Ed Engl 2016 Feb 18;55(8):2894-8. Epub 2016 Jan 22 doi: 10.1002/anie.201509935. PMID: 26800384
Kovjazin R, Horn G, Smorodinsky NI, Shapira MY, Carmon L
PLoS One 2014;9(1):e85400. Epub 2014 Jan 8 doi: 10.1371/journal.pone.0085400. PMID: 24416403Free PMC Article
Deng J, Wang L, Chen H, Li L, Ma Y, Ni J, Li Y
Cancer Metastasis Rev 2013 Dec;32(3-4):535-51. doi: 10.1007/s10555-013-9423-y. PMID: 23609751
Kimura T, Finn OJ
Expert Opin Biol Ther 2013 Jan;13(1):35-49. Epub 2012 Sep 24 doi: 10.1517/14712598.2012.725719. PMID: 22998452
Sharma S, Srivastava MK, Harris-White M, Lee JM, Dubinett S
Expert Opin Biol Ther 2011 Aug;11(8):987-90. doi: 10.1517/14712598.2011.598146. PMID: 21711210Free PMC Article

Therapy

Stergiou N, Glaffig M, Jonuleit H, Schmitt E, Kunz H
ChemMedChem 2017 Sep 7;12(17):1424-1428. Epub 2017 Aug 7 doi: 10.1002/cmdc.201700387. PMID: 28675699
Shi L, Cai H, Huang ZH, Sun ZY, Chen YX, Zhao YF, Kunz H, Li YM
Chembiochem 2016 Aug 3;17(15):1412-5. Epub 2016 Jun 15 doi: 10.1002/cbic.201600206. PMID: 27188544
Zhang H, Liu C, Zhang F, Geng F, Xia Q, Lu Z, Xu P, Xie Y, Wu H, Yu B, Wu J, Yu X, Kong W
Vaccine 2016 May 23;34(24):2648-55. Epub 2016 Apr 22 doi: 10.1016/j.vaccine.2016.04.045. PMID: 27113167
Hu B, Wang J, Guo Y, Chen T, Ni W, Yuan H, Zhang N, Xie F, Tai G
Int Immunopharmacol 2016 Apr;33:108-18. Epub 2016 Feb 17 doi: 10.1016/j.intimp.2016.02.006. PMID: 26896668
Carmon L, Avivi I, Kovjazin R, Zuckerman T, Dray L, Gatt ME, Or R, Shapira MY
Br J Haematol 2015 Apr;169(1):44-56. Epub 2014 Dec 11 doi: 10.1111/bjh.13245. PMID: 25496030

Prognosis

Arriola E, Ottensmeier C
Immunotherapy 2016 May;8(5):511-9. doi: 10.2217/imt-2016-0015. PMID: 27140406
Beatty PL, Finn OJ
Ann N Y Acad Sci 2013 May;1284:52-6. doi: 10.1111/nyas.12108. PMID: 23651193
Kimura T, Finn OJ
Expert Opin Biol Ther 2013 Jan;13(1):35-49. Epub 2012 Sep 24 doi: 10.1517/14712598.2012.725719. PMID: 22998452
Lakshminarayanan V, Thompson P, Wolfert MA, Buskas T, Bradley JM, Pathangey LB, Madsen CS, Cohen PA, Gendler SJ, Boons GJ
Proc Natl Acad Sci U S A 2012 Jan 3;109(1):261-6. Epub 2011 Dec 14 doi: 10.1073/pnas.1115166109. PMID: 22171012Free PMC Article
Kovjazin R, Volovitz I, Kundel Y, Rosenbaum E, Medalia G, Horn G, Smorodinsky NI, Brenner B, Carmon L
Vaccine 2011 Jun 24;29(29-30):4676-86. Epub 2011 May 12 doi: 10.1016/j.vaccine.2011.04.103. PMID: 21570434

Clinical prediction guides

Carmon L, Avivi I, Kovjazin R, Zuckerman T, Dray L, Gatt ME, Or R, Shapira MY
Br J Haematol 2015 Apr;169(1):44-56. Epub 2014 Dec 11 doi: 10.1111/bjh.13245. PMID: 25496030
Fang F, Ma J, Ni W, Wang F, Sun X, Li Y, Li Q, Xie F, Wang J, Zhai R, Liu Z, Gao S, Tai G
Mol Med Rep 2014 Aug;10(2):1056-64. Epub 2014 Jun 10 doi: 10.3892/mmr.2014.2306. PMID: 24912810
Geraci C, Consoli GM, Granata G, Galante E, Palmigiano A, Pappalardo M, Di Puma SD, Spadaro A
Bioconjug Chem 2013 Oct 16;24(10):1710-20. Epub 2013 Sep 16 doi: 10.1021/bc400242y. PMID: 24041198
Lakshminarayanan V, Thompson P, Wolfert MA, Buskas T, Bradley JM, Pathangey LB, Madsen CS, Cohen PA, Gendler SJ, Boons GJ
Proc Natl Acad Sci U S A 2012 Jan 3;109(1):261-6. Epub 2011 Dec 14 doi: 10.1073/pnas.1115166109. PMID: 22171012Free PMC Article
Kovjazin R, Volovitz I, Kundel Y, Rosenbaum E, Medalia G, Horn G, Smorodinsky NI, Brenner B, Carmon L
Vaccine 2011 Jun 24;29(29-30):4676-86. Epub 2011 May 12 doi: 10.1016/j.vaccine.2011.04.103. PMID: 21570434

Recent systematic reviews

Peres Lde P, da Luz FA, Pultz Bdos A, Brígido PC, de Araújo RA, Goulart LR, Silva MJ
Biotechnol Adv 2015 Dec;33(8):1868-77. Epub 2015 Oct 30 doi: 10.1016/j.biotechadv.2015.10.013. PMID: 26523780
Hall RD, Gray JE, Chiappori AA
Cancer Control 2013 Jan;20(1):22-31. PMID: 23302904
Yuan S, Shi C, Liu L, Han W
Expert Opin Biol Ther 2010 Jul;10(7):1037-48. doi: 10.1517/14712598.2010.485185. PMID: 20420512
Shumway NM, Ibrahim N, Ponniah S, Peoples GE, Murray JL
BioDrugs 2009;23(5):277-87. doi: 10.2165/11313490-000000000-00000. PMID: 19754218
Mitchell MS
Curr Opin Investig Drugs 2002 Jan;3(1):150-8. PMID: 12054066

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