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Headache associated with sexual activity(HSA)

MedGen UID:
95989
Concept ID:
C0393754
Sign or Symptom
Synonyms: BENIGN SEXUAL HEADACHE; HSA
SNOMED CT: Headache associated with sexual activity (103010005)
 
OMIM®: 607504

Definition

The International Headache Society (1988) classifies headache associated with sexual activity (HSA) as an idiopathic headache under 'miscellaneous headaches unassociated with structural lesions.' Based on initial descriptions, 3 subtypes are differentiated: type 1 is a dull ache in the head and neck that slowly intensifies as sexual excitement increases, and is believed to be caused by muscle contraction similar to tension-type headache; type 2, also called 'vascular-type,' is a sudden severe, explosive headache occurring at orgasm, which may be due to increased intracranial pressure; type 3, the most uncommon type, is a postural headache resembling that caused by decreased CSF pressure, perhaps due to a meningeal tear during coitus (summary by Frese et al., 2003). [from OMIM]

Recent clinical studies

Etiology

Donnet A, Valade D, Houdart E, Lanteri-Minet M, Raffaelli C, Demarquay G, Hermier M, Guegan-Massardier E, Gerardin E, Geraud G, Cognard C, Levrier O, Lehmann P
Neuroradiology 2013 Feb;55(3):297-305. Epub 2012 Nov 2 doi: 10.1007/s00234-012-1110-0. PMID: 23117256
Frese A, Rahmann A, Gregor N, Biehl K, Husstedt IW, Evers S
Cephalalgia 2007 Nov;27(11):1265-70. Epub 2007 Oct 5 doi: 10.1111/j.1468-2982.2007.01449.x. PMID: 17919305
Biehl K, Evers S, Frese A
Cephalalgia 2007 Nov;27(11):1271-3. Epub 2007 Jul 26 doi: 10.1111/j.1468-2982.2007.01381.x. PMID: 17655717
Frese A, Frese K, Ringelstein EB, Husstedt IW, Evers S
Cephalalgia 2003 Sep;23(7):545-51. doi: 10.1046/j.1468-2982.2003.00579.x. PMID: 12950381
Evers S, Schmidt O, Frese A, Husstedt IW, Ringelstein EB
Pain 2003 Mar;102(1-2):73-8. PMID: 12620598

Diagnosis

Utku U
Med Princ Pract 2013;22:588-9. Epub 2013 May 3 doi: 10.1159/000350415. PMID: 23652575Free PMC Article
Yeh YC, Fuh JL, Chen SP, Wang SJ
Cephalalgia 2010 Nov;30(11):1329-35. Epub 2010 Apr 13 doi: 10.1177/0333102410364675. PMID: 20959427
Allena M, Rossi P, Tassorelli C, Ferrante E, Lisotto C, Nappi G
J Headache Pain 2010 Dec;11(6):525-30. Epub 2010 Oct 2 doi: 10.1007/s10194-010-0261-9. PMID: 20890719Free PMC Article
Kim HJ, Seo SY
J Neurol Sci 2008 Oct 15;273(1-2):142-3. Epub 2008 Jul 26 doi: 10.1016/j.jns.2008.06.020. PMID: 18656903
Larner AJ
J Headache Pain 2006 Jun;7(3):139-40. Epub 2006 Jun 15 doi: 10.1007/s10194-006-0297-z. PMID: 16767532Free PMC Article

Therapy

Halker RB, Vargas BB
Curr Pain Headache Rep 2013 Jun;17(6):337. doi: 10.1007/s11916-013-0337-8. PMID: 23606018
Lee JW, Ha YS, Park SC, Seo IY, Lee HS
J Sex Med 2013 Jul;10(7):1893-6. Epub 2013 Feb 19 doi: 10.1111/jsm.12093. PMID: 23421378
Anand KS, Dhikav V
Singapore Med J 2009 May;50(5):e176-7. PMID: 19495503
Frese A, Rahmann A, Gregor N, Biehl K, Husstedt IW, Evers S
Cephalalgia 2007 Nov;27(11):1265-70. Epub 2007 Oct 5 doi: 10.1111/j.1468-2982.2007.01449.x. PMID: 17919305
Evers S, Schmidt O, Frese A, Husstedt IW, Ringelstein EB
Pain 2003 Mar;102(1-2):73-8. PMID: 12620598

Prognosis

Yeh YC, Fuh JL, Chen SP, Wang SJ
Cephalalgia 2010 Nov;30(11):1329-35. Epub 2010 Apr 13 doi: 10.1177/0333102410364675. PMID: 20959427
Evers S, Peikert A, Frese A
Headache 2009 Sep;49(8):1234-5. Epub 2009 Jul 27 doi: 10.1111/j.1526-4610.2009.01498.x. PMID: 19656219
Frese A, Rahmann A, Gregor N, Biehl K, Husstedt IW, Evers S
Cephalalgia 2007 Nov;27(11):1265-70. Epub 2007 Oct 5 doi: 10.1111/j.1468-2982.2007.01449.x. PMID: 17919305
Frese A, Gantenbein A, Marziniak M, Husstedt IW, Goadsby PJ, Evers S
Cephalalgia 2006 Dec;26(12):1458-61. doi: 10.1111/j.1468-2982.2006.01224.x. PMID: 17116096
Chakravarty A
Cephalalgia 2006 Feb;26(2):202-7. doi: 10.1111/j.1468-2982.2005.01027.x. PMID: 16426276

Clinical prediction guides

Hambach A, Evers S, Summ O, Husstedt IW, Frese A
Cephalalgia 2013 Apr;33(6):384-9. Epub 2013 Feb 19 doi: 10.1177/0333102413476374. PMID: 23430983
Donnet A, Valade D, Houdart E, Lanteri-Minet M, Raffaelli C, Demarquay G, Hermier M, Guegan-Massardier E, Gerardin E, Geraud G, Cognard C, Levrier O, Lehmann P
Neuroradiology 2013 Feb;55(3):297-305. Epub 2012 Nov 2 doi: 10.1007/s00234-012-1110-0. PMID: 23117256
Frese A, Rahmann A, Gregor N, Biehl K, Husstedt IW, Evers S
Cephalalgia 2007 Nov;27(11):1265-70. Epub 2007 Oct 5 doi: 10.1111/j.1468-2982.2007.01449.x. PMID: 17919305
Frese A, Gantenbein A, Marziniak M, Husstedt IW, Goadsby PJ, Evers S
Cephalalgia 2006 Dec;26(12):1458-61. doi: 10.1111/j.1468-2982.2006.01224.x. PMID: 17116096
Frese A, Frese K, Ringelstein EB, Husstedt IW, Evers S
Cephalalgia 2003 Sep;23(7):545-51. doi: 10.1046/j.1468-2982.2003.00579.x. PMID: 12950381

Recent systematic reviews

Mitsikostas DD, Ashina M, Craven A, Diener HC, Goadsby PJ, Ferrari MD, Lampl C, Paemeleire K, Pascual J, Siva A, Olesen J, Osipova V, Martelletti P; EHF committee.
J Headache Pain 2015;17:5. Epub 2016 Feb 9 doi: 10.1186/s10194-016-0596-y. PMID: 26857820Free PMC Article
Allena M, Rossi P, Tassorelli C, Ferrante E, Lisotto C, Nappi G
J Headache Pain 2010 Dec;11(6):525-30. Epub 2010 Oct 2 doi: 10.1007/s10194-010-0261-9. PMID: 20890719Free PMC Article
Larner AJ
J Sex Med 2008 Feb;5(2):284-8. Epub 2007 Dec 7 doi: 10.1111/j.1743-6109.2007.00654.x. PMID: 18069993

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