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Corticosterone

MedGen UID:
41316
Concept ID:
C0010124
Hormone; Organic Chemical; Pharmacologic Substance
Synonyms: Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-
SNOMED CT: Corticosterone (91521001); Compound B (91521001)
 

Definition

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorticosterone

Recent clinical studies

Etiology

Saracino MA, Iacono C, Somaini L, Gerra G, Ghedini N, Raggi MA
J Pharm Biomed Anal 2014 Jan;88:643-8. Epub 2013 Oct 23 doi: 10.1016/j.jpba.2013.10.008. PMID: 24231793
Wuwongse S, Cheng SS, Wong GT, Hung CH, Zhang NQ, Ho YS, Law AC, Chang RC
Biochim Biophys Acta 2013 Dec;1832(12):2245-56. Epub 2013 Aug 6 doi: 10.1016/j.bbadis.2013.07.022. PMID: 23928361
Auvinen HE, Wang Y, Princen H, Romijn JA, Havekes LM, Smit JW, Meijer OC, Biermasz NR, Rensen PC, Pereira AM
PLoS One 2013;8(5):e63882. Epub 2013 May 22 doi: 10.1371/journal.pone.0063882. PMID: 23717502Free PMC Article
Lee CH, Yoo DY, Park OK, Park JH, Yi SS, Yoon YS, Won MH, Hwang IK
Neurochem Res 2011 Oct;36(10):1767-75. Epub 2011 May 8 doi: 10.1007/s11064-011-0492-4. PMID: 21553256
Newman AE, MacDougall-Shackleton SA, An YS, Kriengwatana B, Soma KK
J Comp Neurol 2010 Sep 15;518(18):3662-78. doi: 10.1002/cne.22395. PMID: 20653028

Diagnosis

Huston JP, Komorowski M, de Souza Silva MA, Lamounier-Zepter V, Nikolaus S, Mattern C, Müller CP, Topic B
Horm Behav 2016 Nov;86:21-26. Epub 2016 Sep 12 doi: 10.1016/j.yhbeh.2016.09.003. PMID: 27633458
Üstyol A, Atabek ME, Taylor N, Yeung MC, Chan AO
J Clin Res Pediatr Endocrinol 2016 Sep 1;8(3):356-9. Epub 2016 Apr 29 doi: 10.4274/jcrpe.2824. PMID: 27125267Free PMC Article
Saracino MA, Iacono C, Somaini L, Gerra G, Ghedini N, Raggi MA
J Pharm Biomed Anal 2014 Jan;88:643-8. Epub 2013 Oct 23 doi: 10.1016/j.jpba.2013.10.008. PMID: 24231793
Plenis A, Konieczna L, Olędzka I, Kowalski P, Bączek T
Mol Biosyst 2011 May;7(5):1487-500. Epub 2011 Feb 21 doi: 10.1039/c0mb00313a. PMID: 21336389
Newman AE, MacDougall-Shackleton SA, An YS, Kriengwatana B, Soma KK
J Comp Neurol 2010 Sep 15;518(18):3662-78. doi: 10.1002/cne.22395. PMID: 20653028

Therapy

Chilvers BL, Finlayson G, Candy EJ, Sriram A, Morgan KJ, Cockrem JF
Mar Pollut Bull 2016 Dec 15;113(1-2):312-315. Epub 2016 Oct 7 doi: 10.1016/j.marpolbul.2016.10.004. PMID: 27726937
Dufour BD, McBride JL
Exp Neurol 2016 Sep;283(Pt A):308-17. Epub 2016 Jul 2 doi: 10.1016/j.expneurol.2016.06.028. PMID: 27381424Free PMC Article
Dinel AL, Rey C, Bonhomme C, Le Ruyet P, Joffre C, Layé S
Prostaglandins Leukot Essent Fatty Acids 2016 Jun;109:29-38. Epub 2016 Apr 20 doi: 10.1016/j.plefa.2016.03.013. PMID: 27269711
Finger JW Jr, Thomson PC, Adams AL, Benedict S, Moran C, Isberg SR
Gen Comp Endocrinol 2015 Feb 1;212:63-72. Epub 2015 Jan 31 doi: 10.1016/j.ygcen.2015.01.023. PMID: 25644211
Saracino MA, Iacono C, Somaini L, Gerra G, Ghedini N, Raggi MA
J Pharm Biomed Anal 2014 Jan;88:643-8. Epub 2013 Oct 23 doi: 10.1016/j.jpba.2013.10.008. PMID: 24231793

Prognosis

Dufour BD, McBride JL
Exp Neurol 2016 Sep;283(Pt A):308-17. Epub 2016 Jul 2 doi: 10.1016/j.expneurol.2016.06.028. PMID: 27381424Free PMC Article
Ovejero R, Novillo A, Soto-Gamboa M, Mosca-Torres ME, Cuello P, Gregório P, Jahn G, Carmanchahi P
J Exp Zool A Ecol Genet Physiol 2013 Dec;319(10):539-47. Epub 2013 Sep 30 doi: 10.1002/jez.1833. PMID: 24115389
Shikatani EA, Trifonova A, Mandel ER, Liu ST, Roudier E, Krylova A, Szigiato A, Beaudry J, Riddell MC, Haas TL
PLoS One 2012;7(10):e46625. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0046625. PMID: 23056375Free PMC Article
Fidler JA, Treleaven CM, Frakes A, Tamsett TJ, McCrate M, Cheng SH, Shihabuddin LS, Kaspar BK, Dodge JC
FASEB J 2011 Dec;25(12):4369-77. Epub 2011 Aug 29 doi: 10.1096/fj.11-190819. PMID: 21876068Free PMC Article
Poisbleau M, Demongin L, Trouve C, Quillfeldt P
Horm Behav 2009 Apr;55(4):500-6. Epub 2009 Feb 14 doi: 10.1016/j.yhbeh.2009.02.002. PMID: 19232349

Clinical prediction guides

Wuwongse S, Cheng SS, Wong GT, Hung CH, Zhang NQ, Ho YS, Law AC, Chang RC
Biochim Biophys Acta 2013 Dec;1832(12):2245-56. Epub 2013 Aug 6 doi: 10.1016/j.bbadis.2013.07.022. PMID: 23928361
Auvinen HE, Wang Y, Princen H, Romijn JA, Havekes LM, Smit JW, Meijer OC, Biermasz NR, Rensen PC, Pereira AM
PLoS One 2013;8(5):e63882. Epub 2013 May 22 doi: 10.1371/journal.pone.0063882. PMID: 23717502Free PMC Article
Shikatani EA, Trifonova A, Mandel ER, Liu ST, Roudier E, Krylova A, Szigiato A, Beaudry J, Riddell MC, Haas TL
PLoS One 2012;7(10):e46625. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0046625. PMID: 23056375Free PMC Article
Lee CH, Yoo DY, Park OK, Park JH, Yi SS, Yoon YS, Won MH, Hwang IK
Neurochem Res 2011 Oct;36(10):1767-75. Epub 2011 May 8 doi: 10.1007/s11064-011-0492-4. PMID: 21553256
Sun Z, Fan Y, Zha Q, Zhu MY
J Neurochem 2010 Apr;113(1):105-16. Epub 2010 Jan 13 doi: 10.1111/j.1471-4159.2010.06587.x. PMID: 20070865Free PMC Article

Recent systematic reviews

Hardiman RL, Bratt A
Physiol Behav 2016 Dec 1;167:341-353. Epub 2016 Oct 5 doi: 10.1016/j.physbeh.2016.09.030. PMID: 27720735
Crews D, Gillette R, Miller-Crews I, Gore AC, Skinner MK
Mol Cell Endocrinol 2014 Dec;398(1-2):42-52. Epub 2014 Aug 4 doi: 10.1016/j.mce.2014.07.013. PMID: 25102229Free PMC Article
Groeneweg FL, Karst H, de Kloet ER, Joëls M
J Endocrinol 2011 May;209(2):153-67. Epub 2011 Feb 28 doi: 10.1530/JOE-10-0472. PMID: 21357682
Koolhaas JM, Bartolomucci A, Buwalda B, de Boer SF, Flügge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgoifo A, Steimer T, Stiedl O, van Dijk G, Wöhr M, Fuchs E
Neurosci Biobehav Rev 2011 Apr;35(5):1291-301. Epub 2011 Feb 21 doi: 10.1016/j.neubiorev.2011.02.003. PMID: 21316391
Truckenmiller ME, Bonneau RH, Norbury CC
Brain Behav Immun 2006 May;20(3):210-8. Epub 2006 Feb 28 doi: 10.1016/j.bbi.2006.01.002. PMID: 16504465

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