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Elevated alpha-fetoprotein

MedGen UID:
65916
Concept ID:
C0235971
Finding
Synonyms: Alpha fetoprotein abnormal; Increased levels of alpha fetoprotein; Increased serum alpha-fetoprotein
 
HPO: HP:0006254

Definition

An increased concentration of alpha-fetoprotein. [from HPO]

Recent clinical studies

Etiology

Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. [Epub ahead of print] PMID: 25921665
Khazardoost S, Mousavi S, Borna S, Hantoushzadeh S, Alavi A, Khezerlou N
J Matern Fetal Neonatal Med 2014 Apr;27(6):561-5. Epub 2013 Aug 7 doi: 10.3109/14767058.2013.822483. [Epub ahead of print] PMID: 23901798
Kim BS, Hayashi PH, Kim SH, Angthong W, Srirattanapong S, Woosley JT, Semelka RC
Radiology 2013 Jul;268(1):109-19. Epub 2013 Feb 7 doi: 10.1148/radiol.13121314. [Epub ahead of print] PMID: 23392426
Han SL, Wu XL, Jia ZR, Wang PF
Hong Kong Med J 2010 Oct;16(5):400-2. PMID: 20890007
Hsu SX, Siegel AB, Berk PD
Semin Liver Dis 2010 Feb;30(1):99-106. Epub 2010 Feb 19 doi: 10.1055/s-0030-1247136. PMID: 20175037

Diagnosis

Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. [Epub ahead of print] PMID: 25921665
Pendlebury A, Rischin D, Ireland-Jenkin K, Toner GC, Grant P
J Clin Oncol 2015 Aug 20;33(24):e99-100. Epub 2014 Apr 7 doi: 10.1200/JCO.2013.49.8998. [Epub ahead of print] PMID: 24711556
Liu XL, Zhang LY, Li FQ, Liang YH, Wei QZ, Liu LX, Cui HY
World J Surg Oncol 2013 Sep 23;11:238. doi: 10.1186/1477-7819-11-238. [Epub ahead of print] PMID: 24059753Free PMC Article
Ahn JS, Jeon JR, Yoo HS, Park TK, Park CK, Sinn DH, Paik SW
Clin Mol Hepatol 2013 Jun;19(2):173-8. Epub 2013 Jun 27 doi: 10.3350/cmh.2013.19.2.173. PMID: 23837142Free PMC Article
Kim BS, Hayashi PH, Kim SH, Angthong W, Srirattanapong S, Woosley JT, Semelka RC
Radiology 2013 Jul;268(1):109-19. Epub 2013 Feb 7 doi: 10.1148/radiol.13121314. [Epub ahead of print] PMID: 23392426

Therapy

Khazardoost S, Mousavi S, Borna S, Hantoushzadeh S, Alavi A, Khezerlou N
J Matern Fetal Neonatal Med 2014 Apr;27(6):561-5. Epub 2013 Aug 7 doi: 10.3109/14767058.2013.822483. [Epub ahead of print] PMID: 23901798
Ahn JS, Jeon JR, Yoo HS, Park TK, Park CK, Sinn DH, Paik SW
Clin Mol Hepatol 2013 Jun;19(2):173-8. Epub 2013 Jun 27 doi: 10.3350/cmh.2013.19.2.173. PMID: 23837142Free PMC Article
Okur A, Pinarli FG, Karadeniz C, Poyraz A, Fidan K, Basaklar C, Oguz A
Tumori 2012 Nov;98(6):179e-82e. doi: 10.1700/1217.13518. PMID: 23389381
Akuta N, Suzuki F, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Arase Y, Ikeda K, Kumada H
J Med Virol 2008 Aug;80(8):1354-62. doi: 10.1002/jmv.21202. PMID: 18551609
Dahlmann N, Hartlapp JH
Klin Wochenschr 1989 Apr 3;67(7):408-12. PMID: 2473243

Prognosis

Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. [Epub ahead of print] PMID: 25921665
Liu XL, Zhang LY, Li FQ, Liang YH, Wei QZ, Liu LX, Cui HY
World J Surg Oncol 2013 Sep 23;11:238. doi: 10.1186/1477-7819-11-238. [Epub ahead of print] PMID: 24059753Free PMC Article
Kim BS, Hayashi PH, Kim SH, Angthong W, Srirattanapong S, Woosley JT, Semelka RC
Radiology 2013 Jul;268(1):109-19. Epub 2013 Feb 7 doi: 10.1148/radiol.13121314. [Epub ahead of print] PMID: 23392426
Han SL, Wu XL, Jia ZR, Wang PF
Hong Kong Med J 2010 Oct;16(5):400-2. PMID: 20890007
Hsu SX, Siegel AB, Berk PD
Semin Liver Dis 2010 Feb;30(1):99-106. Epub 2010 Feb 19 doi: 10.1055/s-0030-1247136. PMID: 20175037

Clinical prediction guides

Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. [Epub ahead of print] PMID: 25921665
Kim BS, Hayashi PH, Kim SH, Angthong W, Srirattanapong S, Woosley JT, Semelka RC
Radiology 2013 Jul;268(1):109-19. Epub 2013 Feb 7 doi: 10.1148/radiol.13121314. [Epub ahead of print] PMID: 23392426
Bonfig W, Hempel M, Teichert-von Lüttichau I, Liptay S, Burdach S
J Pediatr Hematol Oncol 2012 Oct;34(7):e301-3. doi: 10.1097/MPH.0b013e3182441256. PMID: 22430587
Chen CH, Lin ST, Kuo CL, Nien CK
Hepatogastroenterology 2008 Jul-Aug;55(85):1423-7. PMID: 18795704
Akuta N, Suzuki F, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Arase Y, Ikeda K, Kumada H
J Med Virol 2008 Aug;80(8):1354-62. doi: 10.1002/jmv.21202. PMID: 18551609

Recent systematic reviews

Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC
J Clin Oncol 2015 Jan 10;33(2):195-201. Epub 2014 Dec 1 doi: 10.1200/JCO.2014.58.3369. [Epub ahead of print] PMID: 25452439Free PMC Article
Xue TC, Zhang L, Xie XY, Ge NL, Li LX, Zhang BH, Ye SL, Ren ZG
PLoS One 2014;9(5):e96072. Epub 2014 May 2 doi: 10.1371/journal.pone.0096072. PMID: 24788770Free PMC Article
Mavros MN, Mayo SC, Hyder O, Pawlik TM
J Am Coll Surg 2012 Dec;215(6):820-30. Epub 2012 Sep 13 doi: 10.1016/j.jamcollsurg.2012.08.001. [Epub ahead of print] PMID: 22981432

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